Studies on drug release from ointments. V. Release of hydrocortisone butyrate propionate from topical dosage forms to silicone rubber

Tanaka, Shigeo; Takashima, Yasuji; Murayama, Hiroshi; Tsuchiya, Susumu

doi:10.1016/0378-5173(85)90182-6

Cited by 18 publications

(5 citation statements)

References 7 publications

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“…Consequently, the same permeation rate of methyl paraben across the membrane is obtained for both DMI and TC based formulations. Similar findings have been reported by Tanaka et al (1985) with silicone membranes while studying the influence of the evaporation of formulation components in the release of hydrocortisone butyrate propionate from oil-inwater cream and aqueous gel formulations. The authors compared drug release from several propylene glycol-based aqueous gels containing ethanol under occluded and non-occluded conditions, and also monitored the evaporation kinetics from the formulations.…”

Section: Ipm Dmi and Tcsupporting

confidence: 83%

The influence of volatile solvents on transport across model membranes and human skin

Oliveira

Hadgraft

Lane

2012

International Journal of Pharmaceutics

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Section: Ipm Dmi and Tcsupporting

confidence: 83%

The influence of volatile solvents on transport across model membranes and human skin

Oliveira

Hadgraft

Lane

2012

International Journal of Pharmaceutics

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“…Similarly, the significantly higher solvent evaporation from the lotion could result in an increase in the concentration of RD and/or produce a supersaturated state in formulation which is a possible mechanism of its increased permeation after a single application and large application volumes (20 µL/cm 2 ) (Oliveira et al, 2012). Differences in the skin permeation of model compounds in previous studies were attributed to changes in drug solubility/ thermodynamic activity in the residual phase induced by the evaporation of solvents (i.e., water) from the formulation (Oliveira et al, 2012;Tanaka et al, 1985).…”

Section: Discussionmentioning

confidence: 99%

Effect of layered application on the skin permeation of a cosmetic active component, rhododendrol

et al. 2019

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Cosmetics containing rhododendrol (RD) were voluntarily recalled after incidents of leukoderma related to their use. Users reported using up to five different RD-containing products by layered application. In this study, we investigated the effects of layered application, formulations, and their components on the skin permeation of cosmetics containing RD. Experiments were designed to simulate actual in-use conditions, such as varying application volumes, physical mixing of formulations, sequence of cosmetics application and time interval between applications, to establish their effect on the skin permeation of RD. Milk and lotion RD-containing cosmetics (2%), 1% aqueous RD, and preparations of formulation components were applied as the first or second layers as finite doses of 10 or 20 µL/cm 2 . Permeation experiments were performed through excised porcine ear skin using Franz diffusion cells with an effective diffusion area of 1.77 cm 2 . Cosmetics applied by layered application exhibited lower skin permeation of RD compared with a single application despite having the same application dose. High initial volume (20 µL at 0 or 5 sec) did not exhibit any significant reduction in the permeation of RD. Formulations and their components caused varying reductions in RD permeation, probably due to changes in thermodynamic activity of the active component. Layered application, formulation components, application volume, time interval and sequence of application had significant influences on the skin permeation of the active component. Moreover, this study established a method of investigating the influence of formulations and their components on the skin permeation of actives after layered application.

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“…However, the percentage of zinc absorbed from emulsions A and B was found to be sig nificantly higher than that obtained from emulsion C, although the latter contained the .ugliest zinc concentration (7.02 versus 1.26% for A and 1.27% for B). Furthermore, fluxes of zinc from the 3 emulsions were found to be very similar, although the applied dose of Zn2+ was greater in emulsion C. Diffusion of zinc from topically applied zinc oxide, which is practically insoluble in water (4-6 pg/ml), may be less important than from ZnPC (data not reported), and ZnS04 (965 mg/ml) highly soluble in water, especially when considering that evaporation of water from emulsion de creases the availability of zinc salt in the vehi cle [13]. In crystalline form, ZnO may have a partition coefficient (vehicle/stratum corncum) lower than those of ZnPC and ZnS04, which would reduce the diffusion into the skin.…”

Section: Percutaneous Absorption O F Zincmentioning

confidence: 96%

In vitro Study of Percutaneous Absorption, Cutaneous Bioavailability and Bioequivalence of Zinc and Copper from Five Topical Formulations

Pirot¹,

Millet²,

Kalia

et al. 1996

Skin Pharmacol Physiol

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Percutaneous absorption and cutaneous bioavailability of zinc and copper from zinc 2-pyrrolidone 5-carboxylate (ZnPC), zinc oxide (ZnO), zinc sulfate (ZnSO₄), copper 2-pyrrolidone 5-carboxylate (CuPC) and copper sulfate (CuSO₄) were compared using 5 formulations (3 emulsions and 2 ointments) that were applied topically on human skin in vitro. After application for 72 h, percutaneous absorption of zinc from ointments containing ZnO and ZnSO₄ was found to be lower than that from a ZnPC-containing emulsion (0.36 and 0.34 versus 1.60% of applied dose). In the case of copper, the flux after a 72-hour treatment period showed that there had been minimal release from CuPC- and CuSO₄-containing formulations (approximately 5 ng/cm²/h). All formulations used in this study effected an increase in zinc and copper concentrations in whole skin and epidermis. Bioequivalence of the 5 formulations based on pharmacokinetic results was assessed, and salt and vehicle effects were discussed.

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Studies on drug release from ointments. V. Release of hydrocortisone butyrate propionate from topical dosage forms to silicone rubber

Cited by 18 publications

References 7 publications

The influence of volatile solvents on transport across model membranes and human skin

The influence of volatile solvents on transport across model membranes and human skin

Effect of layered application on the skin permeation of a cosmetic active component, rhododendrol

In vitro Study of Percutaneous Absorption, Cutaneous Bioavailability and Bioequivalence of Zinc and Copper from Five Topical Formulations

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