Studies on effect of monosodium glutamate (MSG) on various fractions of lipids and certain carbohydrate metabolic enzymes in liver and blood of adult male mice

Malik, Vinay; Ahluwalia, Preeti

doi:10.1016/0378-4274(94)90075-2

Cited by 29 publications

(24 citation statements)

References 23 publications

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“…MSG is toxic to the liver and kidney 11 and induces hyperlipidemia and hyperglycemia. 12,28 In addition, the daily administration of MSG significantly increased levels of malondialdehyde and 4-hydroxyalkenals in hepatic microsomes. 12 In our study, administration of BMP to mice treated with MSG exhibited a glutathionesparing effect as well as a preventive action against lipid peroxidation in mouse liver.…”

Section: Discussionmentioning

confidence: 98%

“…The effects of the MSG-induced excitotoxicity in different brain regions and of lipid peroxidation are well documented. 28 Many studies throughout the world have used MSG as a toxic enhancer with an experimental dose of 4 mg=g (or 8 mg=g) of body weight administered intraperitoneally to mice or rats. MSG is toxic to the liver and kidney 11 and induces hyperlipidemia and hyperglycemia.…”

Section: Discussionmentioning

confidence: 99%

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Butterbur (Petasites japonicusMax.) Extract Improves Lipid Profiles and Antioxidant Activities in Monosodiuml-Glutamate-Challenged Mice

Park

Kim

Sok

et al. 2010

Journal of Medicinal Food

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We investigated the effect of the butanol fraction from the methanol extract of butterbur (Petasites japonicus Max.) (BMP) on the plasma lipid profiles and oxidative damage of liver in mice challenged with monosodium l-glutamate (MSG). ICR mice (6-8 weeks old, male) were fed BMP (0.1% or 0.3%) for 1 week, and on day 7, MSG (4 mg/g) was administered intraperitoneally to the mice. Administration of MSG resulted in a significant decrease of antioxidant biomarkers such as total glutathione level and antioxidant enzyme activities such as glutathione reductase (GR), glutathione peroxidase (GPx), glutathione S-transferase (GST), and quinone reductase (NQO1), whereas the thiobarbituric acid-reactive substances (TBARS) value was increased in liver tissue. However, BMP supplementation markedly enhanced the hepatic antioxidant enzyme activities, including GPx, GR, GST, and NQO1, whereas it lowered TBARS, compared to the MSG-treated group. Moreover, BMP supplementation decreased total cholesterol, atherogenic index, and low-density lipoprotein-cholesterol, compared to the MSG-treated group. Based on these results, it was proposed that BMP improve the plasma lipid profiles and decrease the oxidative stress by up-regulating the hepatic antioxidant enzymes in mice challenged with MSG.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Butterbur (Petasites japonicusMax.) Extract Improves Lipid Profiles and Antioxidant Activities in Monosodiuml-Glutamate-Challenged Mice

Park

Kim

Sok

et al. 2010

Journal of Medicinal Food

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“…The present results would strongly suggest that the higher leptin secretion in MSGtreated rats is consistent with the observations of increased adipogenesis in the visceral fat and augmented lipogenesis in the parietal fat. In view of the elevated circulating levels of lipids in MSG-lesioned rats, investigators have suggested that this animal model develops, in a MSG-dose-dependent fashion, a shift in carbohydrate metabolism towards lipogenesis, thus leading to hyperlipidemia [Malik and Ahluwalia, 1994]. This fact has been partially attributed to the hyperinsulinemia characteristic of MSG-treated animals [Oida et al, 1984].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Pituitary and Adipose Tissue after Hypothalamic Denervation in the Female Rat

Camihort

Dumm

Luna

et al. 2005

Cells Tissues Organs

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Neonatal administration of monosodium glutamate (MSG) to rats produces severe lesions in certain hypothalamic nuclei, with repercussions in different neuroendocrine axes, and serves as a model for their study. In addition, adipose tissue, as a target organ, is known to be directly related to several neurondocrine axes. We used 21-day-old female Sprague-Dawley rats that had received a neonatal treatment with MSG (4 mg/g body weight, i.p., from day 2 up to day 10 of age) in addition to control rats (injected with 10% NaCl solution, on a similar schedule). We performed a specific immunohistochemical study on each anterior-pituitary cell population, along with the morphometry of these cells and of the parietal and visceral adipose tissue, and measured the levels of serum leptin and triglycerides. The MSG animals evinced significant changes in volume density (VD), cell density (CD), and cell size (CS) in the corticotropes, thyrotropes, and LH gonadotropes, but not in the somatotropes, lactotropes, and FSH gonadotropes. The modification common to the three cell types was a hyperplasia, but with different results depending on cell size. Furthermore, in the MSG rats significant changes were also observed in the VD, CD, and CS of the adipose tissue, consisting of adipogenesis and decrease of adipocyte size in visceral fat, together with probable lipogenesis as judged by an increase in adipocyte size in the parietal fat. The serum levels of leptin and triglycerides appeared significantly higher in MSG animals. For the first time in this animal model, and at the level of three neuroendocrine axes, our results suggest changes that correlate hypothalamic damage, cellular pituitary alterations, and the response of the adipose tissue as a target organ for MSG insult.

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“…These results were accordance with those reported by Diniz et al (2004) who found that administration of MSG was associated with oxidative stress in hepatic tissues, leading to increased glycogen content of liver cells as a result of hyperglycemia and hyperinsulinemia. Malik and Ahluwalia (1994) reported that subcutaneous administration of MSG to adult mice (dose level over 4 mg/g b.wt.) caused a significant increase in the content of liver glycogen, total lipids, phospholipids, free fatty acids and triglycerides.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative effects of melatonin on the liver of pregnant albino rats and their offspring induced by monosodium glutamate

2016

Res. Opin. Anim. Vet. Sci.

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Monosodium glutamate (MSG) is one of the most widely used food additives as a flavour enhancer but its high dose can induce toxic effects on the liver. Melatonin is a potent antioxidant, could ameliorate acute and chronic hepatic injury. The present work was essentially designed to evaluate the ameliorating role of melatonin on the liver of pregnant female Albino rats and their pups induced by MSG. In the present research, twenty four pregnant Albino rats were divided into four groups (n=6). The control group received saline solution, the melatonin group received 100 mg/kg b.wt, MSG treated group received 400 mg/kg b.wt and ameliorative group received MSG 400 mg/kg b.wt simultaneously with melatonin 100 mg/kg b.wt. All groups were received their corresponding dose from the 4 th day of gestation till the end of weaning period. The histological study of the current work revealed that MSG could induce damage of hepatocytes with cytoplasmic vacuolation, dilation of central vein and blood sinusoids, prominent Kupffer cells, infiltration cells around the portal area, variable degree of fibrosis, and scattered fatty cells. Furthermore, MSG consumption is also associated with ultrastructural alterations that varied considerably from mild structural changes to cytoplasmic lysis and degradation of some cellular organelles. Such alterations were represented by undifferentiated cytoplasm with dispersed vacuoles, nuclear pyknosis, swollen and vacuolated mitochondria, manifested dilated rough endoplasmic reticulum, remarkable aggregation of glycogen granules and fat droplets and obvious dispersion of collagenous fibers. Supplementation of melatonin ameliorated MSG-induced histopathological and ultrastrucural changes in liver cells. Keywords: MSG, Liver, Melatonin, Histopathlology, Fibrosis, TEM, HepatocytesTo cite this article: Abd El-Fattah BM El-Beltagy, 2016. Ameliorative effects of melatonin on the liver of pregnant albino rats and their offspring induced by monosodium glutamate. Res. Opin. Anim. Vet. Sci., 6(2): 59-68.

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Studies on effect of monosodium glutamate (MSG) on various fractions of lipids and certain carbohydrate metabolic enzymes in liver and blood of adult male mice

Cited by 29 publications

References 23 publications

Butterbur (Petasites japonicusMax.) Extract Improves Lipid Profiles and Antioxidant Activities in Monosodiuml-Glutamate-Challenged Mice

Butterbur (Petasites japonicusMax.) Extract Improves Lipid Profiles and Antioxidant Activities in Monosodiuml-Glutamate-Challenged Mice

Relationship between Pituitary and Adipose Tissue after Hypothalamic Denervation in the Female Rat

Ameliorative effects of melatonin on the liver of pregnant albino rats and their offspring induced by monosodium glutamate

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