Studies on glycogen storage disease type 1a animal models: a brief perspective

Petrova, I. O.; Smirnikhina, Svetlana

doi:10.1007/s11248-022-00325-7

Transgenic Res

2022

DOI: 10.1007/s11248-022-00325-7

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Studies on glycogen storage disease type 1a animal models: a brief perspective

I. O. Petrova

Svetlana Smirnikhina

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2023

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Gluconeogenesis Flux in Metabolic Disease

Shah,

Wondisford

2023

Annu. Rev. Nutr.

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Gluconeogenesis is a critical biosynthetic process that helps maintain whole-body glucose homeostasis and becomes altered in certain medical diseases. We review gluconeogenic flux in various medical diseases, including common metabolic disorders, hormonal imbalances, specific inborn genetic errors, and cancer. We discuss how the altered gluconeogenic activity contributes to disease pathogenesis using data from experiments using isotopic tracer and spectroscopy methodologies. These in vitro, animal, and human studies provide insights into the changes in circulating levels of available gluconeogenesis substrates and the efficiency of converting those substrates to glucose by gluconeogenic organs. We highlight ongoing knowledge gaps, discuss emerging research areas, and suggest future investigations. A better understanding of altered gluconeogenesis flux may ultimately identify novel and targeted treatment strategies for such diseases.

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Gluconeogenesis Flux in Metabolic Disease

Shah,

Wondisford

2023

Annu. Rev. Nutr.

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Studies on glycogen storage disease type 1a animal models: a brief perspective

Cited by 1 publication

References 79 publications

Gluconeogenesis Flux in Metabolic Disease

Gluconeogenesis Flux in Metabolic Disease

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