Studies on Human Bile II: Influence of two different fats on the composition of human bile

Dam, H.; Kruse, Inger; Jensen, Morten Krogh; Kallehauge, H. E.

doi:10.3109/00365516709090652

Cited by 48 publications

(6 citation statements)

References 12 publications

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“…The efficacy of dietary treatment of these metabolic disor ders can be shown even concurrent to the use of serum cholesterol-lowering drugs [1], Changes of dietary habits have also been sug gested for the general public to lower the risk of cardiovascular disorders due to athero sclerosis. Objections have been raised, how ever, against a greater use of cholesterol-low ering diets because unfavorable side effects were suspected [2][3][4], In particular, changes in bile composition have been reported which could lead to a greater incidence of gallstones [3], though these findings could not be confirmed in a later study [5]. Fur thermore, in a postmortem investigation of most participants of a long-term study for primary and secondary prevention of coro nary heart disease gallstones were found to be more common in those who had been on a fat-modified diet than in the control group [4], Again, these results could not be repro duced by other investigators [6], Previous investigations of cholesterol saturation in bile subsequent to changes in dietary fat composition have not yielded unequivocal answers, possibly because of the small num ber and the heterogeneity of subjects in volved.…”

Section: Introductioncontrasting

confidence: 39%

Metabolic Changes in Healthy Men Using Fat-Modified Diets

Kohlmeier¹,

Schlierf²,

Stiehl³

1988

Ann Nutr Metab

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The composition of fasting gallbladder bile was investigated in a group of 14 healthy men both on their normal diets and on a low cholesterol diet containing less saturated and more polyunsaturated fat given twice for 4 weeks. These dietary changes caused a 21.6% reduction of total serum cholesterol levels. With the use of the fat-modified diet lithogenic indices of fasting gallbladder bile were not significantly changed despite increased relative concentrations of bile acids and decreased relative concentrations of phospholipids and cholesterol in bile. Thus, the experiment provided no evidence for an increased cholelithiasis risk in healthy men ingesting ‘prudent diets’.

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Section: Introductioncontrasting

confidence: 39%

Metabolic Changes in Healthy Men Using Fat-Modified Diets

Kohlmeier¹,

Schlierf²,

Stiehl³

1988

Ann Nutr Metab

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“…Olesen (18) reported augmentation of euglobulin-and serum-fibrinolytic activity by relatively large concentrations of cholate, tauroglycocholate, and taurocholate. Our bile salt mixture contained much lower concentrations of cholate and taurocholate (40 mM), more closely approximating that in duodenal juice -52.7 mM (19). Five min after interaction of the mixture with bovine plasma in the presence of human euglobulin at room temperature, an aliquot was added to streptokinase (200 units per ml) and CaC1 2 , and fibrinolytic activity was measured (Fig.…”

Section: ~----mentioning

confidence: 99%

The Effects of Bile Salts on Some Coagulation Components and Related Enzymes

Am¹,

Alexander²

1972

Thromb Haemost

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SummaryCertain purified bile salts, individually or in a mixture, profoundly affect - either inhibiting or enhancing - the esterolytic activities of thrombin, trypsin, and plasmin, the clotting activity of thrombin, and caseinolysis by trypsin. They also promote SK-induced fibrinolysis and impair FI clottability. These effects are directly related to bile salt concentration but not to the critical micellar concentration.A very unusual effect was observed with deoxycholate and FI : besides inhibiting FI clottability, the salt induces spontaneous gelation. In addition, it binds strongly to the protein, as has been already reported for another plasma protein, albumin, and to a lesser degree, to alpha- and beta-globulins.Noteworthy is the fact that activation of pancreatic juice trypsinogen by thrombin also was increased by prior thrombin exposure to the salts. On the other hand, thrombin-induced platelet aggregation was slightly inhibited by the bile salt mixture, which, when added to PRP moderately inhibited the ADP-induced aggregation. No effect was observed on the conversion of F II in plasma via the thromboplastic mechanism when deoxycholate, or cholate, or glycocholate was added to the system.It is postulated that the bile salt mixture enhances SK-induced fibrinolysis by direct action, either on SK, or on the SK-activator complex, attributable to the detergent properties of the salts.The physiologic and pathologic implications of our results with respect to hemostasis and pancreatitis are discussed.

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“…Sin embargo, aun no se ha dilucidado el impacto que ejercen dietas altas en grasas en los lípidos biliares, debido a diferencias en el metabolismo lipídico inherentes al huésped, en el momento de la intervención dietética. Se han realizado estudios metabólicos en sujetos con perfil lipídico en el rango normal e hiperlipidémicos, con y sin cálculos vesiculares, pero sin lograr obtener un patrón consistente 1,2 . Inicialmente se postuló, que la adición de grasas en dietas destinadas a reducir el peso corporal, podrían disminuir la incidencia de colelitiasis, al potenciar la contractibilidad de la vesícula biliar 3 .…”

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Efecto de una dieta alta en grasas en el proceso de formación de cálculos biliares de colesterol

et al. 2017

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Background: It is known that some nutrients play an important role in the development of cholelithiasis. Cholesterol is carried by micelles and vesicles inL a litiasis biliar es considerada una patología metabólica multifactorial, siendo la dieta un factor importante en el desarrollo de esta patología. Al respecto, existen antecedentes que sugieren que una dieta alta en grasas es un probable factor predisponente para el desarrollo de litiasis biliar. Sin embargo, aun no se ha dilucidado el impacto que ejercen dietas altas en grasas en los lípidos biliares, debido a diferencias en el metabolismo lipídico inherentes al huésped, en el momento de la intervención dietética. Se han realizado estudios metabólicos en sujetos con perfil lipídico en el rango normal e hiperlipidémicos, con y sin cálculos vesiculares, pero sin lograr obtener un patrón consistente 1,2 . Inicialmente se postuló, que la adición de grasas en dietas destinadas a reducir el peso corporal, podrían disminuir la incidencia de colelitiasis, al potenciar la contractibilidad de la vesícula biliar 3 . Sin embargo, se han reportado resultados contradictorios, indicando que la elevada contractibilidad vesicular por alta ingesta de grasas, no es suficiente explicación para la coleli- Se ha logrado establecer, que una dieta excesiva en colesterol, es un factor predisponente a hiperlipidemia, y puede inducir una sobresaturación de la bilis y formación de cálculos vesiculares. Sin embargo, el tipo de dieta grasa, y específicamente ciertos ácidos grasos, pueden también influenciar la colelitiasis [5][6][7][8] . Ensayos realizados en un modelo animal de conejos con hipercolesterolemia, señalan que la ingesta de una dieta alta en ácidos grasos monoinsaturados, logran normalizar los porcentajes de lípidos biliares, reduciendo el índi-ce litogénico; por el contrario, una dieta alta en áci-dos grasos ω-3-poliinsaturados incrementaron el índice litogénico 9 . En hámsteres se ha informado, que la incorporación de ácidos grasos saturados a la dieta incrementan los efectos litogénicos 10,11

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Studies on Human Bile II: Influence of two different fats on the composition of human bile

Cited by 48 publications

References 12 publications

Metabolic Changes in Healthy Men Using Fat-Modified Diets

Metabolic Changes in Healthy Men Using Fat-Modified Diets

The Effects of Bile Salts on Some Coagulation Components and Related Enzymes

Efecto de una dieta alta en grasas en el proceso de formación de cálculos biliares de colesterol

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