Studies on Hypoglycaemic activity of the different extracts of Solanum torvum root

Abstract

The objective of the study was to Studies on the hypoglycaemic activity of the different extracts of Solanum torvum (Solanaceae) root extracts on Wister albino rats. Solanum torvum roots were shade dried, powdered, and extracted by the Soxhlet extraction procedure using petroleum ether, chloroform, ethanol, and water. Swiss albino mice were chosen for the acute toxicity studies and follow the OECD guidelines 423. The hypoglycemic activity on adult Wistar albino rats at dose levels of 100, 200, and 400mg/kg p.o. respectively each using normoglycaemic, glucose loaded, and streptozotocin-induced hyperglycaemic rats. For activity comparison standard drug Metformin (150mg/kg) was used. Promising results were produced by the ethanol extract among all the tested extracts that are comparable to the reference standard metformin. The study entrenched the scientific foundation of the benefits of this plant in the medication of diabetes and asserts the use of the root of the plant for treating diabetes as demonstrate in folklore remedies.