Studies on monocomponent insulin. IV. Subcutaneous absorption of insulin from preparations with protracted action.

A method is described which measures the prolongation effects of commercial insulin suspensions by monitoring the rate of solution of an insulin suspension into a phosphate buffer, pH 7.4, at 37 degrees C. The method can rapidly categorize an insulin into the clinical classifications of either fast, intermediate or slow acting. It offers advantages of speed and sensitivity over the British Pharmacopoeial test for prolongation of insulin effect in fasted animals. Large differences between the dissolution rates of commercial samples of isophane insulin were observed which suggested a lack of bioequivalence.

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An in-vitro test for the duration of action of insulin suspensions

Graham

Pomeroy

1984

Journal of Pharmacy and Pharmacology

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Studies on monocomponent insulin. V. Pharmacokinetics of soluble insulin preparations using in situ animal model.

Kasama¹,

Oshiro²,

Uchida³

et al. 1980

Journal of Pharmacobio-Dynamics

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Studies on monocomponent insulin. IV. Subcutaneous absorption of insulin from preparations with protracted action.

Cited by 2 publications

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An in-vitro test for the duration of action of insulin suspensions

An in-vitro test for the duration of action of insulin suspensions

Studies on monocomponent insulin. V. Pharmacokinetics of soluble insulin preparations using in situ animal model.

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