Studies on N-Allylnormorphine in Man: Antagonism to Morphine and Heroin and Effects of Mixtures of N-Allylnormorphine and Morphine

Hf, Fraser; Jd, Van Horn; Isbell, Harris

doi:10.1097/00000441-195601000-00001

Cited by 20 publications

(3 citation statements)

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“…The antagonism of morphine by nalorphine has been explained in several ways. Fraser and colleagues, 6 after mentioning that nalorphine is an antagonist but depresses respiration when given alone, suggested the following:…”

Section: Discussionmentioning

confidence: 99%

The interaction of morphine and nalorphine on respiration

Bellville

Fleischli

1968

Clin Pharma and Therapeutics

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A study was carried out in volunteers to determine the relative potency as respiratory depressants of nalorphine and morphine and their interaction when administered together. The relative potency of nalorphine when compared to morphine was found to be 0.74 (13.5 mg. nalorphine ≎ 10 mg. morphine). The data are consistent with the hypothesis that antagonism of the respiratory effects of morphine by nalorphine is related primarily to differences in intrinsic activity of the drugs and not solely in their receptor affinity. Thus, their interaction could be classified as competitive dualism.

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Section: Discussionmentioning

confidence: 99%

The interaction of morphine and nalorphine on respiration

Bellville

Fleischli

1968

Clin Pharma and Therapeutics

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“…Through its historical role in relation to the CDAN (which became the Committee on Problems of Drug Dependence [CPDD] in 1965), ARC researchers enjoyed constant access to new analgesic compounds. During the 1950s and 1960s, the Committee turned to studying the narcotic antagonists, including nalorphine; 27–32 naltrexone; 33 LAAM (long‐acting methadyl acetate), a long‐acting derivative of methadone May synthesized under CPDD auspices; 34 cyclazocine; 35 phenazocine; 36 and pentazocine 37 . Although dating from Committee discussions in the 1940s, this route of experimentation intensified during the synthetic flood of the 1950s.…”

Section: The Mid‐20th Century Project To Develop Narcotic Antagonistsmentioning

confidence: 99%

The history of the development of buprenorphine as an addiction therapeutic

Campbell

Lovell

2012

Annals of the New York Academy of Sciences

120

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This paper traces the early 21st century success of the agonist-antagonist buprenorphine and the combination drug buprenorphine with naloxone within the broader quest to develop addiction therapeutics that began in the 1920s as the search for a nonaddictive analgesic. Drawing on archival research, document analysis, and interviews with contemporary actors, this paper situates the social organization of laboratory-based and clinical research within the domestic and international confluence of several issues, including research ethics, drug regulation, public attitudes, tensions around definitions of drug addiction, and the evolving roles of the pharmaceutical industry. The fervor that drove the champions of buprenorphine must be understood in relation to (1) the material work of research and pharmaceutical manufacturing; (2) the symbolic role of buprenorphine as a solution to numerous problems with addiction treatment evident by the mid-1970s; the destigmatization and individualization of addicts as patients; and (3) the complex configurations of public and private partnerships.

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“…Our knowledge regarding nalorphine as a morphine antagonist is mainly based on experimental and clinical experience with this substance in morphine intoxication (UNNA 1943, WOODS 1956, FRASER 1957. In general the drug behaves as a narcotic antagonist in the presence of a strong narcotic effect; in the absence of a narcotic effect it behaves as a narcotic, in the presence of narcotic addition it produces withdrawal symptoms.…”

Section: Influence Of Nalorphine On the Sphinctermentioning

confidence: 99%

Influence of Nalorphine on the Sphincter of Oddi Studied by Roentgencinematography

Lindgren¹,

Saltzman²

1961

Acta Radiologica

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It has long been known that morphine increases the tone of unstriated intestinal muscle in general and hence that of the sphincter of Oddi as well. Most substances belonging to the morphine group, both natural and synthetic, are considered to exercise a similar influence on unstriated muscle. Nalorphine (N -allylnormorphine) (WINTER et colI. 1954) forms an exception in this respect since it is considered that this substance has an antagonistic effect on the tonic action of morphine (HART and MCCAWLEY 1944).During the last few years we have studied the influence of various drugs upon the sphincter of Oddi by means of a system consisting of an image intensifier and a film camera adapted for roentgencinematography. Nalorphine has also come in for attention in this connection, and as our results diverge in certain respects from the view generally held we considered they were worth placing on record.Our knowledge regarding nalorphine as a morphine antagonist is mainly based on experimental and clinical experience with this substance in morphine

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Studies on N-Allylnormorphine in Man: Antagonism to Morphine and Heroin and Effects of Mixtures of N-Allylnormorphine and Morphine

Cited by 20 publications

References 0 publications

The interaction of morphine and nalorphine on respiration

The interaction of morphine and nalorphine on respiration

The history of the development of buprenorphine as an addiction therapeutic

Influence of Nalorphine on the Sphincter of Oddi Studied by Roentgencinematography

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