Studies on nigerian plants v. comparative anatomy of lophira lanceolata and lophira alata

Persinos, Georgia J.; Quimby, Maynard W.

doi:10.1007/bf02861955

Cited by 6 publications

(7 citation statements)

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“…The reducing power of methanolic extract and chalcone dimers (lophirones B and C) derived from Lophira alata stem bark was evaluated by adopting the procedure described by Oyaizu. 18 Varying amounts of the extract and lophirones B and C (0.2-1.0 mg/mL) were suspended in 1 mL of distilled water and mixed with 2.5 mL of 0.2 M phosphate buffer (pH 6.6) and 2.5 mL of 1% potassium ferricyanide [K 3 Fe(CN) 6 ]. The mixture was incubated at 50 C for 20 minutes, after which 2.5 mL of trichloroacetic acid was added to the mixture.…”

Section: Cell Viability ð%þ ¼mentioning

confidence: 99%

“…Thus, the scavenging effect of Lophira alata stem bark methanolic extract and its chalcone dimers (lophirones B and C) on O 2 Á, OHÁ, and H 2 O 2 suggests capability to terminate LPO, which could arise from O 2 Á, and stronger reactive oxygen species (eg, OÁ, OHÁ, and H 2 O 2 ). 35 The significant (P < .05) reducing power on K 3 Fe(CN) 6 by Lophira alata stem bark and its chalcone dimers (lophirones B and C) suggest that it can help prevent oxidation of cellular macromolecules. It also shows the capability of these compounds to prevent damages that could result from Fenton reaction of Fe 2þ .…”

Section: Free Radicals and Reactive Oxygen Species Scavenging Activitiesmentioning

confidence: 99%

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Cytotoxic, Antimutagenic, and Antioxidant Activities of Methanolic Extract and Chalcone Dimers (Lophirones B and C) Derived From Lophira alata (Van Tiegh. Ex Keay) Stem Bark

Ajiboye

Yakubu

Oladiji

2013

J Evid Based Complementary Altern Med

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The cytotoxic, antimutagenic, and antioxidant activities of methanolic extract and lophirones B and C derived from Lophira alata stem bark were evaluated. The extract and lophirones B and C significantly (P < .05) reduced the viability of Ehrlich ascites carcinoma cells. There were concentration-dependent reduction in 4-nitro-o-aminophenylenediamine and benzo[a]pyrene-induced frame shift mutation as well as aflatoxin B1-induced base pair substitution by the extract and lophirones B and C. The extract and lophirones B and C concentration dependently scavenged DPPH radical, superoxide anion radical, hydrogen peroxide, hydroxyl radicals, and reduced ferric ion in the potassium hexacyanoferrate III reducing system. The results obtained from this study revealed that methanolic extract and lophirones B and C derived from Lophira alata stem bark posses anticancer, antimutagenic, and antioxidant activities, with lophirone C producing the best anticancer, antimutagenic, and antioxidant activities. The acclaimed anticancer activity of Lophira alata may be attributed to lophirones B and C.

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Section: Cell Viability ð%þ ¼mentioning

confidence: 99%

Section: Free Radicals and Reactive Oxygen Species Scavenging Activitiesmentioning

confidence: 99%

Cytotoxic, Antimutagenic, and Antioxidant Activities of Methanolic Extract and Chalcone Dimers (Lophirones B and C) Derived From Lophira alata (Van Tiegh. Ex Keay) Stem Bark

Ajiboye

Yakubu

Oladiji

2013

J Evid Based Complementary Altern Med

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“…Lophira alata (Ochnaceae), known as Aba, Akufo (Igbo), Ekki (Yoruba), and Namijin kadai (Hausa), grows in the tropical rainforest of Africa such as Sierra Leone, Uganda, and Sudan . The plant is used in the management of toothache in Cameroon, liver infections in Togo, and female sterility, fever, dysentery, respiratory problems, cough, and cancer in Nigeria .…”

Section: Introductionmentioning

confidence: 99%

Electrophilic and Reactive Oxygen Species Detoxification Potentials of Chalcone Dimers is Mediated by Redox Transcription Factor Nrf‐2

Ajiboye

Yakubu

Oladiji

2013

J Biochem & Molecular Tox

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Nuclear erythroid related factor-2 (Nrf2), a redox-transcription factor, plays a critical role in the detoxification of electrophilic and reactive oxygen species that halt various biochemical and molecular processes. This makes it a candidate for regulation by polyphenols. This study investigates the capability of chalcone dimers (lophirones B and C) to induce expressions and activities of cytoprotective enzymes. Chalcone dimers administration to rats not only induced the Nrf2, but also suppressed cytoplasmic Kelch-like ECH-associated protein 1 (Keap1) expressions. In addition, the chalcone dimers significantly (p < 0.05) increased the expressions and activities of nicotinamide adenine dinucleotide and reduced quinone oxidoreductase-1, glutathione-S-transferase, epoxide hydrolase and uridyl glucuronosyl transferase in rat liver. Also, activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase in rat liver increased significantly (p < 0.05). Overall, lophirones B and C increased the expressions and activities of cytoprotective proteins in rat liver possibly through the reduction of cytoplasmic Keap1 expression, leading to the nuclear translocation of Nrf2.

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“…Both Lophira species possess the same number of chromosomes (2n = 28, Satabié 1982) and similar morphology of pollen, flower, fruit. Apart from the tree size, the main distinguishing morphological traits concern leaf branch texture (smooth in L. alata vs. scaly-corky in L. lanceolata) and petiole size which are shorter in L. alata than in L. lanceolata (von Thieme 1929; see also Persinos and Quimby 1968). Lophira flowers are large, whitish, hermaphrodite and fragrant, producing numerous stamens with yellow to orange anthers (Meunier et al 2015), and bee-pollinated (Mapongmetsem 2007;Oriana Bhasin, pers.…”

Section: Study Species Habitat and Usesmentioning

confidence: 99%

“…ex Keay, which occurs in regions with a marked dry season (Aubreville 1959;Hutchinson and Dalziel 1954;Bamps 1970;Biwole et al 2012). These species differ in their general stature (L. alata reaches much larger sizes than L. lanceolata) but they are otherwise very similar morphologically (Aubreville 1959) so that their origin and relationships are unclear (Persinos and Quimby 1968). They have sometimes been considered as synonyms (Keay 1953), assumed to be distinct morphotypes resulting from ecological adaptations (Letouzey 1968).…”

Section: Introductionmentioning

confidence: 99%

Species delimitation in the African tree genus Lophira (Ochnaceae) reveals cryptic genetic variation

et al. 2020

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Species delimitation remains a crucial issue for widespread plants occurring across forest-savanna ecotone such as Lophira (Ochnaceae). Most taxonomists recognize two parapatric African tree species, widely distributed and morphologically similar but occurring in contrasted habitats: L. lanceolata in the Sudanian dry forests and savannahs and L. alata in the dense Guineo-Congolian forests. Both species co-occur along a c. 3000 km long forest-savanna mosaic belt, constituting ideal models for investigating hybridization patterns and the impact of past glacial periods on the genetic structures in two types of ecosystems. We genotyped 10 nuclear microsatellites for 803 individuals sampled across the distribution range of Lophira. Both species exhibit similar levels of genetic diversity (He = 0.52 (L. alata); 0.44 (L. lanceolata)) and are well differentiated, consistent with taxonomic delimitation (FST = 0.36; RST = 0.49), refuting the hypothesis that they might constitute ecotypes rather than distinct species. Furthermore, L. alata displayed two deeply differentiated clusters (FST = 0.37; RST = 0.53) distributed in parapatry, one endemic to Western Gabon while another cluster extended over the remaining species range, suggests that L. alata is made of two cryptic species. We showed that rare hybrids occur in some contact zones between these three species, leaving a weak signal of introgression between L. lanceolata and the northern cluster of L. alata. At the intra-specific level, the latter species also show weak genetic structuring between Upper and Lower Guinea and the intensity did not differ strikingly between rainforest and savanna ecosystems. The discovery of a new species of Lophira with a narrow distribution in West Gabon where it is intensively exploited for its timber requires to evaluate its conservation status.

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Studies on nigerian plants v. comparative anatomy of lophira lanceolata and lophira alata

Cited by 6 publications

References 0 publications

Cytotoxic, Antimutagenic, and Antioxidant Activities of Methanolic Extract and Chalcone Dimers (Lophirones B and C) Derived From Lophira alata (Van Tiegh. Ex Keay) Stem Bark

Cytotoxic, Antimutagenic, and Antioxidant Activities of Methanolic Extract and Chalcone Dimers (Lophirones B and C) Derived From Lophira alata (Van Tiegh. Ex Keay) Stem Bark

Electrophilic and Reactive Oxygen Species Detoxification Potentials of Chalcone Dimers is Mediated by Redox Transcription Factor Nrf‐2

Species delimitation in the African tree genus Lophira (Ochnaceae) reveals cryptic genetic variation

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