Studies on oral absorption of stearic acid SLN by a novel fluorometric method

Yuan, Hong; Chen, Jian; Du, Yong‐Zhong; Hu, Fuqiang; Zeng, Su; Zhao, Hang-Li

doi:10.1016/j.colsurfb.2007.03.002

Cited by 160 publications

(77 citation statements)

References 19 publications

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“…Similar types of nanoparticles have been reported to be stable and suitable for oral delivery (108). They are absorbed through the lymphatic system and then enter the systemic circulation, hence passing gastrointestinal metabolism (109,110). A recent study by Grandhi and colleagues (111) has demonstrated high efficacy of the combination of aspirin and curcumin in such nanoparticles in the prevention of pancreatic cancer in an animal model.…”

Section: Discussionmentioning

confidence: 89%

Repurposing of Metformin and Aspirin by Targeting AMPK-mTOR and Inflammation for Pancreatic Cancer Prevention and Treatment

Yang

DiPaola

et al. 2014

Cancer Prevention Research

138

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Pancreatic cancer, as the fourth leading cause of cancer-related deaths, carries a poor prognosis with a median survival of 6 months and a dismal 5-year survival rate of 3% to 5%. These statistics highlight an urgent need for novel chemopreventive and therapeutic strategies for this malignancy. Metformin and aspirin have been explored as two emerging cancer chemoprevention agents for different types of cancers, including pancreatic cancer. Here, we review the effects of both metformin and aspirin on pancreatic tumorigenesis and their potential actions in pancreatic cancer. Special attention is paid to their effects on the important signaling pathways of pancreatic cancer development as well as possible mechanisms for synergy between these two agents. For metformin, the most important mechanism may involve the inhibition of mTOR signaling via AMP-activated protein kinase (AMPK)-dependent and -independent pathways. For aspirin, the major mechanism is the anti-inflammatory action through the inhibition of COX-1/COX-2 and modulation of the NFkB or STAT3 pathway. In addition, aspirin may activate AMPK, and both agents may affect Notch, Wnt/b-catenin, and other signaling pathways. The combination of metformin and aspirin will provide additive and possibly synergistic effects for the prevention and treatment of pancreatic cancer. Cancer Prev Res; 7(4); 388-97. Ó2014 AACR.

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Section: Discussionmentioning

confidence: 89%

Repurposing of Metformin and Aspirin by Targeting AMPK-mTOR and Inflammation for Pancreatic Cancer Prevention and Treatment

Yang

DiPaola

et al. 2014

Cancer Prevention Research

138

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“…Pharmaceutical applications for solid lipid particles include oral, parenteral, and topical drug delivery. 7,[10][11][12][13][14][15][16][17][18] Advantages include improved bioavailability, controlled release, and stabilization. Limitations include drug loading capacity and reports of drug expulsion during storage.…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of Polyunsaturated Fatty Acid Esters with Solid Lipid Particles

Holser

2011

Lipid�Insights

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Encapsulation of structurally sensitive compounds within a solid lipid matrix provides a barrier to prooxidant compounds and effectively limits the extent of oxidative degradation. This offers a simple approach to preserve the bioactivity of labile structures. The technology was developed for cosmetic and pharmaceutical products but may be applied to additives used in food and feed formulations. The encapsulation of docosahexaenoic acid (DHA) and α-linolenic acid (ALA) was examined as model compounds of current interest in functional foods and feeds. Solid lipid particles were prepared from triglycerides containing saturated and unsaturated fatty acids and evaluated by differential scanning calorimetry. The thermal characteristics of the lipids used to form the particle were related to molecular structure and could be adjusted by selection of the appropriate component fatty acids. Encapsulation by solid lipid particles provides a method to inhibit oxidation and improve shelf life of products formulated with DHA and ALA.

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“…When NMs are detected with an incorporated label, for example, with a fluorescent molecule or a radioisotope, a level of uncertainty is introduced since the label could dissociate and be absorbed alone (Yuan et al, 2007). As mentioned, this can be controlled for by testing the degree of dissociation of the label from the NM in the exposure media or in synthetic gastrointestinal fluids, and by the administration of the label alone to a control group (Figure 1).…”

Section: Methodological Considerations For Nanomaterials Detection Andmentioning

confidence: 99%

“…Other NM categories such as vitamin B1-coated NPs have also been tested in vivo (Salman et al, 2007). Similarly, Yuan et al (2007) characterized fluorescently labeled engineered lipid-based particles following intragastric administration to rats by gavage. Fluorescence in blood and lymph was detected by spectrophotometry, as an indirect measure of particle absorption through the GI tract.…”

Section: In Vivo Animal Modelsmentioning

confidence: 99%

Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices

Venema²,

et al. 2014

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Engineered metal/mineral, lipid and biochemical macromolecule nanomaterials (NMs) have potential applications in food. Methodologies for the assessment of NM digestion and bioavailability in the gastrointestinal tract are nascent and require refinement. A working group was tasked by the International Life Sciences Institute NanoRelease Food Additive project to review existing models of the gastrointestinal tract in health and disease, and the utility of these models for the assessment of the uptake of NMs intended for food. Gastrointestinal digestion and absorption could be addressed in a tiered approach using in silico computational models, in vitro non-cellular fluid systems and in vitro cell culture models, after which the necessity of ex vivo organ culture and in vivo animal studies can be considered. Examples of NM quantification in gastrointestinal tract fluids and tissues are emerging; however, few standardized analytical techniques are available. Coupling of these techniques to gastrointestinal models, along with further standardization, will further strengthen methodologies for risk assessment.

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Studies on oral absorption of stearic acid SLN by a novel fluorometric method

Cited by 160 publications

References 19 publications

Repurposing of Metformin and Aspirin by Targeting AMPK-mTOR and Inflammation for Pancreatic Cancer Prevention and Treatment

Repurposing of Metformin and Aspirin by Targeting AMPK-mTOR and Inflammation for Pancreatic Cancer Prevention and Treatment

Encapsulation of Polyunsaturated Fatty Acid Esters with Solid Lipid Particles

Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices

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