Studies on Organophosphorus Compounds VII^1,2: Transformation of Steroidal Ketones with Lawesson's Reagent into Thioxo and Heterofused Steroids. Results of Antimicrobial and Antifungal Activity

Synthesis, Voltammetric and Analytical Applications of Some Fluorine Substituted Spirosteroidalthiazolidin‐4‐one Derivatives of Sulfa Drugs

“…6,11,[22][23][24][25] The reactivity of carbonyl groups in the steroidal hormones has been reported. 11 Thus, this study reports the condensation of sulfanilamide, sulfapyridine and sulfadiazine with steroids e.g. testesterone, epiandrosterone and pregesterone in boiling DMF to give the corresponding imino-steroids 1a-c, 2a-c and 3a-c, respectively.…”

“…improving skeletal muscle performance and recovery by controlling catabolism after stress. 11,12 Thiazolidin-4-one and their arylidene derivatives in the last few decades have received great attention in due to their biological, pharmacological properties and as semidrugs for treatment of a type cancer as celecoxib. 6,[13][14][15][16][17] Spirothiazolidinone derivatives have been reported to possess considerable pharmaceutical potentialities.…”

Studies on Organophosphorus Compounds XIII , : Efficient Synthesis of Polyfunctionally Substituted Heterocycles by the Utility of Phosphonium Salts

“…It revealed also a singlet at 2.65 (3H, CH 3 ), two multiplets at δ = 6.85-7.45 and 7.60-7.95 (11H, 10 aromatic proton, and NH), and a singlet at 11.45 for NH proton. In continuation of our previous work on the behavior of phosphorus reagents toward steriods, 12,13 we would like to report here the effect of phosphonium salt 3c and Wittig reagents 19a,b on 3β-hydroxy-5α-androstan-17-cyanoacetylhydrazone (15). 14 When phenyl isothiocyanate was added to androstan derivative 15 in N,N-dimethylformamide containing KOH, the corresponding potassium thioanilide salt 16 was formed.…”

Reaction of Lawesson's reagent with Mannich base hydrochlorides: synthesis of novel 4H-1,3,2-oxathiaphosphorine-2-sulfide derivatives

“…[5][6][7][8][9][10][11] These heterocycles are an important class of compounds in the medicinal chemistry with interesting biological properties including antimicrobial, antifungal and antitumor activities. [12][13][14] In the last few years, it was shown that the reaction of LR with α, β-unsaturated carbonyl compounds [12,[15][16][17] or phenolic Mannich bases [18,19] can lead to 4H-1,3,2-oxathiaphosphorine derivatives. The scope of these reactions is, however, limited and only a *Corresponding author.…”