Studies on pectin formulations for colonic drug delivery

Ashford, Marianne; Fell, John T.; Attwood, David; Sharma, H.L.; Woodhead, Philip J.

doi:10.1016/0168-3659(94)90028-0

Cited by 185 publications

(62 citation statements)

References 23 publications

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“…The degradation of pectin occurs mainly in the colon by pectinolytic enzymes secreted by microorganisms. As a result pectin has increasingly gained acceptance as the carrier polymer for sustained release and site specific delivery dosage forms, such as beads, pellets, tablets, and films [26,27]. Upon addition, pectin forms rigid gels with calcium, which cross-links the galacturonic acid chains [28].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Surfactants-Assisted Folic Acid-Loaded Pectin Submicrospheres: Characterization and Hemocompatibility Assay

2016

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Folic acid is used for preventing and treating multiple diseases and disorders, administered in the form of oral supplements. The present research work was aimed to study the influence of two non-ionic surfactants Poloxamer and Tween 80 (Polysorbate 80) on pectin submicrospheres formulations. Typical natural polymer pectin was used to encapsulate folic acid by cross linking method. The resultant submicrospheres contributed to improve the aqueous solubility to enhance the bioavailability of folic acid. During investigation, it was observed that pectin polymers influenced kinetics of the rate of reaction more intensively than the surfactants. The physical phenomenon caused the change in their size, shape and chemistry of pectin polymers transforming into submicrospheres in aqueous condition. The characteristic differences of submicrospheres were assessed by scanning electron microscopy, differential scanning calorimetry and Fouriertransform infrared spectroscopy. The average diameters of the submicrospheres ranged between 250 and 500 nm. The encapsulation efficiency of submicrospheres ranged between 80 and 96 %. The characteristic swelling behavior of lyophilized submicrospheres was influenced by the ratio of pectin polymers and folic acid used in the formulations. The submicrospheres systems exhibited controlled release of folic acid due to the pH-dependent solubility of pectin polymers in aqueous medium. The submicrospheres showed good haemocompatibility suggesting them to be promising candidates for oral delivery.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Surfactants-Assisted Folic Acid-Loaded Pectin Submicrospheres: Characterization and Hemocompatibility Assay

2016

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“…Certos tipos de oligo-polissacarídeos a exemplo da pectina, quitosana, dextrana, goma guar, galactomana. arabinogalactomana e inulina, têm sido aplicados no desenvolvimento de sistemas enzimaticamente habilitados no controle da liberação de fármacos sítio-alvo-específicos (Ashford et al, 1994;Van Dijk-Wolthuis et al, 1997;Sinha, Kumria, 2001;Codagnone et al, 2004;Cavalcanti et al, 2002;Cavalcanti et al, 2005;Braz, Hechenleitner, Cavalcanti, 2007).…”

Section: Introductionunclassified

Avaliação da pectina-HPMC no processo de revestimento por compressão: I - Estudo da propriedade de intumescimento em núcleos revestidos

Guimarães¹,

Katsuki²,

Zanardo³

et al. 2008

Rev. Bras. Cienc. Farm.

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Neste estudo, comprimidos de teofilina anidra foram revestidos através do processo de revestimento por compressão aplicando sistema binário pectina-HPMC. O método aplicado gerou comprimidos revestidos com características físicas adequadas aos padrões farmacopeicos. Foram avaliadas as características físicas dos comprimidos obtidos em diferentes proporções (80:20, 60:40, 50:50, 40:60, 20:80, 0:100)

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“…This polymer has been suggested as a carrier for colon-specific delivery as well as for sustained-release purposes [3][4][5] . Pectin has been studied in several drug delivery systems, from matrix tablets [6][7][8] to press-coated [7,9,10] and filmcoated tablets [11][12][13] . Several reports have been published on pectin in multiple-unit dosage forms, mainly on hydrogel beads produced by ionotropic gelation of pectin in the presence of calcium ions [14][15][16][17] .…”

Section: Introductionmentioning

confidence: 99%

Extrusion/spheronization of pectin-based formulations. I. Screening of important factors

2001

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This study investigated the possibility of producing pectin-based pellets by extrusion/spheronization. The study also identified factors influencing the process and the characteristics of the resulting product. Three types of pectin with different degrees of amid and methoxyl substitution were studied in combination with different granulation liquids (water, calcium chloride, citric acid, and ethanol) and/or microcrystalline cellulose. Pellets were prepared in a power-consumption-controlled, twinscrew extruder; then they were spheronized and dried. The products were characterized by image analysis, sieving analysis, and disintegration and dissolution tests. The results were evaluated by multivariate analysis. Different additives, either in the granulation liquid or in the powder mixture, influenced the ability of the extruded mass to form pellets (the processability) with this technique. However, the various pectin types responded to modifications to a different extent. Short, nearly spherical pellets are obtained with granulation liquids, such as ethanol, that reduce the swelling ability of pectin. Pellets produced with ethanol are, however, mechanically weak and tend to disintegrate. Pectin molecules with a high degree of free carboxylic acid groups seem to be more sensitive to changes in the granulation liquid. Addition of microcrystalline cellulose as an extrusion aid generally resulted in improvements in shape and size. It was demonstrated that the processability of pectin as well as the characteristics of the products can be influenced in different ways during the process (eg, adding substances to the granulation liquid or to the powder mixture).

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Studies on pectin formulations for colonic drug delivery

Cited by 185 publications

References 23 publications

Evaluation of Surfactants-Assisted Folic Acid-Loaded Pectin Submicrospheres: Characterization and Hemocompatibility Assay

Evaluation of Surfactants-Assisted Folic Acid-Loaded Pectin Submicrospheres: Characterization and Hemocompatibility Assay

Avaliação da pectina-HPMC no processo de revestimento por compressão: I - Estudo da propriedade de intumescimento em núcleos revestidos

Extrusion/spheronization of pectin-based formulations. I. Screening of important factors

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