Studies on Percutaneous Absorption of Drugs. III. Percutaneous Absorption of Drugs through Damaged Skin

Washitake, Mitsunori; Yajima, Tateki; Anmo, Toshio; Arita, Takaichi; Hori, Ryohei

doi:10.1248/cpb.21.2444

Cited by 38 publications

(10 citation statements)

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“…The animal experiment was approved by the Administration Committee at the Life Science Research Center, Josai University, and was carried out in accordance with its guidance. Skin was stripped by removing the stratum corneum with adhesive tape 20 times (13). LSE-high was obtained from Toyobo Co., Ltd.…”

Section: Animals and Skin Samplesmentioning

confidence: 99%

Kinetic Analysis on the Skin Disposition of Cytotoxicity as an Index of Skin Irritation Produced by Cetylpyridinium Chloride: Comparison of In Vitro Data using a Three-Dimensional Cultured Human Skin Model with In Vivo Results in Hairless Mice

Kano

Sugibayashi

2006

Pharm Res

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Section: Animals and Skin Samplesmentioning

confidence: 99%

Kinetic Analysis on the Skin Disposition of Cytotoxicity as an Index of Skin Irritation Produced by Cetylpyridinium Chloride: Comparison of In Vitro Data using a Three-Dimensional Cultured Human Skin Model with In Vivo Results in Hairless Mice

Kano

Sugibayashi

2006

Pharm Res

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“…Therefore, before application, the stratum corneum at the abdominal skin was removed by stripping the skin 20 times with adhesive tape (7). The increase in the plasma eperisone levels after percutaneous administration was unexpectedly rapid.…”

Section: Discussionmentioning

confidence: 99%

Long-Lasting Muscle Relaxant Activity of Eperisone Hydrochloride after Percutaneous Administration in Rats

Matsunaga

Uemura

Yonemoto

et al. 1997

Japanese Journal of Pharmacology

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ABSTRACT-Potencyand duration of muscle relaxant activity of eperisone hydrochloride were examined after percutaneous administration in the intercollicular decerebrated rat rigidity model and compared to those of eperisone after intravenous injection. A continuous movement was loaded on the hindlimb of the rat model to maintain stable rigidity. The tonus of the hindlimb was recorded by EMG from the triceps surae and was quantified by using the public domain NIH Image program. Eperisone ointment administered percutaneously showed significant muscle relaxant activity at 8.4 cm2 (4.2 mg of eperisone)/rat. The effect was dose-dependent and lasted over 60 min. Intravenously injected eperisone showed significant activity at 1.25 mg/kg, but the decrease of tone was lost within 30 min after injection. Plasma eperisone levels were monitored in the same model, and they were well correlated to the dosage. These results suggest that per cutaneously administered eperisone is absorbed efficiently and shows potent and long-lasting muscle relax ant activity.

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“…anesthesia, and debris and excess fat were trimmed off the excised skin. Stripped skin was made by tape-stripping the stratum corneum 20 times before excising from rats (23). The obtained skin piece was then set on the Franz-type diffusion cell, as above.…”

Section: Membrane Permeation Experiments Of Parabensmentioning

confidence: 99%

Mathematical Model to Predict Skin Concentration of Drugs: Toward Utilization of Silicone Membrane to Predict Skin Concentration of Drugs as an Animal Testing Alternative

et al. 2009

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Studies on Percutaneous Absorption of Drugs. III. Percutaneous Absorption of Drugs through Damaged Skin

Cited by 38 publications

References 0 publications

Kinetic Analysis on the Skin Disposition of Cytotoxicity as an Index of Skin Irritation Produced by Cetylpyridinium Chloride: Comparison of In Vitro Data using a Three-Dimensional Cultured Human Skin Model with In Vivo Results in Hairless Mice

Kinetic Analysis on the Skin Disposition of Cytotoxicity as an Index of Skin Irritation Produced by Cetylpyridinium Chloride: Comparison of In Vitro Data using a Three-Dimensional Cultured Human Skin Model with In Vivo Results in Hairless Mice

Long-Lasting Muscle Relaxant Activity of Eperisone Hydrochloride after Percutaneous Administration in Rats

Mathematical Model to Predict Skin Concentration of Drugs: Toward Utilization of Silicone Membrane to Predict Skin Concentration of Drugs as an Animal Testing Alternative

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