Studies on phenol-keto tautomerism, metal ion binding, and free radical scavenging properties of newly synthesized naphthalene-based tetraimine Schiff base

Background: A number of synthetic scaffolds along with natural products have been identified as potent antioxidants. The present study deals with the evaluation of varyingly substituted, medicinally distinct class of compounds “chalcones and bis-chalcones” for their antioxidant potential. Methods: In vitro radical scavenging activities were performed on a series of synthetic chalcones 1-13 and bis-chalcones 14- 18. Results and Discussion: All molecules 1-18 revealed a pronounced 2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2ʹ-azinobis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radicals scavenging potential in the ranges of IC50s = 0.58 ± 0.14 - 1.72 ± 0.03 and 0.49 ± 0.3 - 1.48 ± 0.06 µM, respectively. Ascorbic acid (IC50s = 0.5 ± 0.1 and 0.46 ± 0.17 µM for DPPH and ABTS, respectively) was used as standard radical scavenger. Conclusion: Structure activity relationship (SAR) revealed an active participation of various groups including -SMe and - OMe in scavenging activity.

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Antioxidant and Cytotoxic Activity Studies in Series of Higher Amino Acid Schiff Bases

Özdemir

Gürkan

Demir

et al. 2020

Gazi University Journal of Science

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Studies on phenol-keto tautomerism, metal ion binding, and free radical scavenging properties of newly synthesized naphthalene-based tetraimine Schiff base

Abstract: In this study, a new tetraimine Schiff base (T 1 ) was obtained by the synthesis of diimine Schiff base (D 1 ), the reduction of nitro group of this

Cited by 3 publications

References 49 publications

A Novel Naphthylidene-diimine Chemosensor for Selective Colorimetric and Fluorometric Detection of Al3+ and CN− Ions

A Novel Naphthylidene-diimine Chemosensor for Selective Colorimetric and Fluorometric Detection of Al3+ and CN− Ions

Chalcones and Bis-Chalcones Analogs as DPPH and ABTS Radical Scavengers

Antioxidant and Cytotoxic Activity Studies in Series of Higher Amino Acid Schiff Bases

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