Studies on production of griseofulvin

Dasu, Veeranki Venkata; Panda, T.

doi:10.1007/s004490050707

Cited by 14 publications

(6 citation statements)

References 23 publications

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“…In contrast, it was showed that maximum antibiotics production was obtained at acidic pH (Reddy &Ranganathan, 1985;VenkataDasu and Panda, 1999;Jichenget al, 2008). It has been reported that maximum production of bacitracin and other antibiotics occurred at alkaline pH (Basilioet al, 2003).…”

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confidence: 99%

“…Also environmental factors like incubation temperature, pH and incubation time were found to have profound influence on antibiotic production (Srinivasan et al, 1991;VenkataDasu and Panda, 1999;Sujathaet al, 2005).…”

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confidence: 99%

“…Sujatha, (2005) showed that the best concentration of ammonium nitrate for maximum antibiotic yield being obtained in cultures supplemented with 2.5 g/l of ammonium nitrate. Also the environmental factors like pH, level of inoculum, and incubation period were also found to have profound influence on antibiotic production (VenkataDasu and Panda, 1999;Sujathaet al, 2005). The environmental requirements and tolerance for growth and antibiotic production has been studied in detail.…”

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confidence: 99%

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Production of Antibacterial and AntifungalMetabolites by (S.albovinaceus) Strain no.10/2 and MediaOptimization

Abdelghani¹

2017

AIJB

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A new strain ofActinomycete (S. albovinaceus) no.10/2 with a broad antifungal and antibacterial activitywas isolated from soil sample of Palestine.The medium composition for antibioticproduction fromstrain S.albovinaceus was optimized using shake-flask methodology.The parameters that resulted in maximum antibiotic production are: 1.25 % mannitol and 1 % malt extract were found to be best carbon and nitrogen sources respectively for growth and antifungal and antibacterial production. Similarly initial pH of 7.2, 10 % level of inoculum, incubation period of 96 hrs, and agitation in 250 ml bottom indented flask and medium to flask ratio of 1:10 (aeration) were found to be optimal.Optimization of medium and cultural conditions resulted in good increase inantifungaland antibacterial yield.This is one of the first reports for strain no.10/2 (S. albovinaceus) reported from Palestine soil with antibacterial and antifungal activities.

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Production of Antibacterial and AntifungalMetabolites by (S.albovinaceus) Strain no.10/2 and MediaOptimization

Abdelghani¹

2017

AIJB

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“…The activity of griseofulvin could be due to its planar structure and spatial configuration [ 72 ]. In fact, griseofulvin is an antibiotic fungicide and is now used for the treatment of human mycotic diseases, in veterinary and plant system [ 73 ].…”

Section: Metabolites From Marine Fungimentioning

confidence: 99%

Advances on anticancer fungal metabolites: sources, chemical and biological activities in the last decade (2012–2023)

Evidente

2024

Nat. Prod. Bioprospect.

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Among microorganisms, fungi are the ones that have the most imagination in producing secondary metabolites with the most varied structural differences, which are produced through different biosynthetic pathways. Therefore, they synthesize secondary metabolites classifiable into numerous families of natural compounds such as amino acids, alkaloids, anthraquinones, aromatic compounds, cyclohexene epoxides, furanones, macrolides, naphthoquinones, polyketides, pyrones, terpenes, etc. They also produced metabolites with very complex structures that can not be classified in the known families of natural compounds. Many fungal metabolites show different biological activities with potential applications in agriculture, food chemistry, cosmetics, pharmacology and medicine. This review is focused on the fungal secondary metabolites with anticancer activity isolated in the last ten years. For some metabolites, when described, their biosynthetic origin, the mode of action and the results of structure activity relationships studies are also reported. Graphical Abstract

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“…The recent literature on 1 for activity against cancer and suppression of hepatitis C virus replication, in conjunction with the influx of patents for analogues of 1, indicate the expanding interest in this class of compounds . Production of 1 is well established via industrial fermentation processes . Our interest was to examine cultures that biosynthesize 1 for two complementary reasons.…”

Section: Introductionmentioning

confidence: 99%

qNMR for profiling the production of fungal secondary metabolites

Brooks

Paguigan

Raja

et al. 2017

Magnetic Reson in Chemistry

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Analysis of complex mixtures is a common challenge in natural products research. Quantitative nuclear magnetic resonance spectroscopy (qNMR) offers analysis of complex mixtures at early stages and with benefits that are orthogonal to more common methods of quantitation, including ultraviolet absorption spectroscopy (UV) and mass spectrometry (MS). Several experiments were conducted to construct a methodology for use in analysis of extracts of fungal cultures. A broadly applicable method was sought for analysis of both pure and complex samples through use of an externally calibrated method. This method has the benefit of not contaminating valuable samples with the calibrant, and it passed scrutiny for line fitting and reproducibility. The method was implemented to measure the yield of griseofulvin and dechlorogriseofulvin from three fungal isolates. An isolate of Xylaria cubensis (coded MSX48662) was found to biosynthesize griseofulvin in the greatest yield, 149 ± 8 mg per fermentation, and was selected for further supply experiments.

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Studies on production of griseofulvin

Cited by 14 publications

References 23 publications

Production of Antibacterial and AntifungalMetabolites by (S.albovinaceus) Strain no.10/2 and MediaOptimization

Production of Antibacterial and AntifungalMetabolites by (S.albovinaceus) Strain no.10/2 and MediaOptimization

Advances on anticancer fungal metabolites: sources, chemical and biological activities in the last decade (2012–2023)

qNMR for profiling the production of fungal secondary metabolites

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