This paper presents work on investigating the effect of the initial size of water mist droplets on the evaporation and removal of heat from the fire-induced hot gas layer while travelling through the air in a compartment. The histories of the temperature, diameter and position of droplets with different initial diameters (varied from 100 µm to 1000 µm) are determined considering surrounding air temperatures of 75 °C and 150 °C and a room height of 3.0 m. A water droplet evaporation model (WDEM) developed in a previous study (Fire and Materials 2016; 40:190–205) is employed to navigate this work. The study reveals that tiny droplets (for example, 100 µm) have disappeared within a very short time due to evaporation and travelled a very small distance from the spray nozzle because of their tiny size. In contrast, droplets with a larger diameter (for example, 1000 µm) reached the floor with much less evaporation. In the case of this study, the relative tiny droplets (≤200 µm) have absorbed the highest amount of energy from their surroundings due to their complete evaporation, whereas the larger droplets have extracted less energy due to their smaller area/volume ratios, and their traverse times are shorter. One of the key findings of this study is that the smaller droplets of spray effectively cool the environment due to their rapid evaporation and extraction of heat from the surroundings, and the larger droplets are effective in traversing the hot air or smoke layer and reaching the floor of the compartment in a fire environment. The findings of this study might help in understanding the behaviour of water-mist droplets with different initial diameters in designing a water-mist nozzle.