Studies on Some Benzoxazine-4-one Derivatives with Potential Biological Activity

Habib, O. M. O.; Hassan, Ahmed El-Meka Hussein M.

doi:10.5923/j.ajoc.20120203.02

Cited by 21 publications

(2 citation statements)

References 3 publications

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“…The Benzoxazine nucleus has been known to exhibit significant antimicrobial activity against both bacteria and fungi. Given that the newly synthesized SA-HMDA-BZ also contains the same Benzoxazine nucleus, we conducted antimicrobial activity tests to determine whether it retains the same potent antimicrobial properties as its predecessor [10][11][12][13][14]. Aminomethyl derivatives of benzoxazine have shown potential for use as anticancer, antibacterial, analgesic, and anti-inflammatory agents [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Activity of Novel Bisbenzoxazine Monomer

Soliman,

Aly,

Amer

et al. 2024

Sohag Journal of Sciences

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In this research, a compound called 2,2'-((1E,1'E)-(hexane-1,6-diylbis(azanylylidene))bis(methanylylidene))diphenol (SA-HMDASF) was synthesized by combining salicylaldehyde and hexamethylene diamine. The resulting SA-HMDASF was then reduced using sodium borohydride, leading to the formation of 2,2'-((hexane-1,6-diylbis((SA-HMDA-NH) through a chemical reaction. Subsequently, SA-HMDA-NH was reacted with formaldehyde, resulting in the production of a benzoxazine monomer called SA-HMDA-BZ. To determine the chemical composition of SA-HMDA-BZ, different analytical methods such as FT-IR, 1 H, and 13 C NMR spectroscopy were employed. These methods were crucial in identifying and confirming the molecular composition and arrangement of the compound. Furthermore, Scanning Electron Microscopy (SEM) was used to analyze the surface morphology of SA-HMDA-BZ while its crystalline properties were assessed through X-ray Diffraction (XRD) analysis. These characterization techniques provided valuable insights into the physical attributes and structural properties of SA-HMDA-BZ. Additionally, the antimicrobial activity of SA-HMDA-BZ was investigated, and the results displayed promising outcomes. The compound exhibited notable antimicrobial properties, suggesting its potential as an effective agent against various microorganisms.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Activity of Novel Bisbenzoxazine Monomer

Soliman,

Aly,

Amer

et al. 2024

Sohag Journal of Sciences

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“… , In 2-fluorophenyl derivatives III , the atropisomers could be isolated at ambient temperature (Δ G ‡ = 26.1–26.5 kcal mol –1 , half-lives of racemization of 8.7–17 days), , while those of 2-deuteriophenyl derivatives IV and V could not be separated because of the lower rotational barrier (20–23 kcal mol –1 ) . On the other hand, although bioactive quinazolin-4-one derivatives VI and VII bearing the 2-pyridyl group are also known, the rotational behavior about the N3–(2-pyridyl) bond has not been explored. The steric size of the 2-pyridyl group is smaller than that of a simple phenyl group; hence, it may be difficult to evaluate the rotational stability about the N3–(2-pyridyl) bond.…”

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confidence: 99%

Rotational Behavior about the N3–Pyridyl Bond in 3-(Pyridin-2-yl)quinazolin-4-one and 4-Thione Derivatives

Wang,

Yang,

Homma

et al. 2024

J. Org. Chem.

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The rotational barriers about the N3−(2-pyridyl) bond in 2-iso-propyl-3-(pyridin-2-yl)quinazolin-4-one and the thione analogue were evaluated though VT-NMR measurement of a diastereotopic iso-propyl group followed by a line-shape simulation. In 3-(pyridin-2-yl)quinazoline-4-thione bearing a chiral center as the C2 substituent, the formation of dynamic diastereomers was detected by NMR. The rotational pathway about the N3−(2-pyridyl) bond and the stereochemistries of dynamic diastereomers were revealed through a computational study.

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Synthesis of Some Novel Quinazolinone Derivatives with Anticipated Biological Activity

Marzouk

Shaker

Farghaly

et al. 2017

Journal of Heterocyclic Chem

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The behavior of the benzoxazinone derivative 1 toward nitrogen and carbon nucleophiles was investigated and yielded compounds 2–4, 6, and 7. The oxadiazol derivatives 9–12 were obtained from the interaction of hydrazide 8 with benzoic acid in the presence of phosphoryl chloride and/or carbon disulfide in the presence of KOH followed by alkylation with ethyl iodide and hydrazinolysis with hydrazine hydrate, respectively. The quinazolinone derivatives 13 and 22 were utilized to construct new heterocyclic systems 15–21, 23, and 24 via interaction with different carbon electrophiles. Some of the newly synthesized compounds were characterized on the bases of spectroscopic data. Some of the synthesized compounds were screened for antimicrobial activity.

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Studies on Some Benzoxazine-4-one Derivatives with Potential Biological Activity

Cited by 21 publications

References 3 publications

Synthesis and Antimicrobial Activity of Novel Bisbenzoxazine Monomer

Synthesis and Antimicrobial Activity of Novel Bisbenzoxazine Monomer

Rotational Behavior about the N3–Pyridyl Bond in 3-(Pyridin-2-yl)quinazolin-4-one and 4-Thione Derivatives

Synthesis of Some Novel Quinazolinone Derivatives with Anticipated Biological Activity

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