Studies on strains of Mycoplasma capricolum subsp. capripneumoniae isolated from outbreaks of contagious caprine pleuropneumonia in Eritrea

Houshaymi, Bilal; Tekleghiorghis, T.; Worth, Danny R; Milès, Roger; Nicholas, R. A. J.

doi:10.1016/s0921-4488(02)00093-7

Cited by 6 publications

(9 citation statements)

References 14 publications

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“…They were obtained from the strain bank of the Veterinary Laboratories Agency (now Animal and Plant Health Agency), Addlestone, UK. Their identity was confirmed by serological and molecular amplification methods (Houshaymi et al, 2002). The Mycoplasma bovis type strain NCTC 10131was included as a negative control in one hybridisation experiment.…”

Section: Mycoplasma Strainsmentioning

confidence: 98%

“…All of the glucose oxidising strains (except G183) metabolised organic acids at significantly higher rates than glucose. The Eritrean strains used in the present study were isolated from outbreaks in goat herds with very high mortality rates (Houshaymi et al, 2002). All strains metabolised glycerol at a high rate, a feature potentially important in pathogenicity because of the accompanying hydrogen peroxide production which may have accounted for the seriousness of the outbreaks.…”

Section: Molecular Studiesmentioning

confidence: 99%

“…CCPP is characterised by respiratory distress, coughing, nasal discharge and severe fibrinous pleuropneumonia. It is a significant disease of goats in Africa, the Middle East and parts of Asia, and can cause mortality of up to 80% in immunologically naїve herds (Houshaymi et al, 2002). The members of the M. mycoides cluster show close genetic and immunological similarity which has led to difficulties for differential diagnosis .…”

Section: Introductionmentioning

confidence: 99%

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Mycoplasma capricolum subsp. capripneumoniae, the cause of contagious caprine pleuropneumonia, comprises two distinct biochemical groups

2018

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Mycoplasma capricolum subsp. capripneumoniae, the cause of the World Organisation of Animal Health- listed contagious caprine pleuropneumonia, is a member of the Mycoplasma mycoides cluster which comprises five pathogenic mycoplasmas of ruminants. These mycoplasmas are closely related immunologically and genetically which can lead to difficulties for differential diagnosis. The patterns of substrate metabolism of strains of M. c. capripneumoniae, gathered from diverse geographic regions, were studied by measurement of oxygen uptake rates. The strains fell into two major biochemical groups: one which only oxidised organic acids and glycerol and the other which could additionally metabolise sugars. Furthermore when DNA-DNA hybridisation tests were carried out these two groups of strains could be separated by their degree of DNA homology, the mean hybridisation value between members of the two groups was 86% well above the value of 70% normally used to indicate separate species. DNA-DNA hybridisation was also carried out between M. c. capripneumoniae strains and other members of the M. mycoides cluster. These experiments used labelled DNA from two representative subsp. capripneumoniae strains; these were 7/1a (organic acid-oxidising) and 4/2 LC (glucose-oxidising). The results showed a particularly close relationship of the glucose-oxidising strain to M leachii strains.

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Section: Mycoplasma Strainsmentioning

confidence: 98%

Section: Molecular Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mycoplasma capricolum subsp. capripneumoniae, the cause of contagious caprine pleuropneumonia, comprises two distinct biochemical groups

2018

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“…Sending frozen samples is recommended but not always practical. During the investigation of CCPP in Eritrea, excellent isolation rates of M. c. capripneumoniae were achieved from lyophilized lung samples even though isolation was not carried out for several weeks after arrival (Houshaymi et al., 2000). Choice of medium is critical, and best results were obtained during the same investigation using a commercial medium (Mycoplasma Experience, Reigate) (Houshaymi et al., 2002).…”

Section: Diagnosismentioning

confidence: 99%

“…For a long time, goats were believed to be the only susceptible host for CCPP (Litamoi et al., 1990) although it was reported that sheep could be infected and seroconvert in the face of close contact (Bölske et al., 1996). Following the introduction of CCPP into Eritrea with the livestock of returning refugees from Sudan, sheep mixing with affected goats were reported to be suffering from respiratory disease (Houshaymi et al., 2000). More recently, there have been confirmed reports from Qatar of CCPP in wild captive ungulates including wild goat, Nubian ibex, Larisstan mouflon and gerenuk kept in animal breeding parks (Arif et al., 2007).…”

Section: Host Susceptibilitymentioning

confidence: 99%

Contagious Caprine Pleuropneumonia: New Aspects of an Old Disease

Nicholas

Churchward

2011

Transboundary and Emerging Diseases

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Contagious caprine pleuropneumonia (CCPP), caused by Mycoplasma capricolum subsp. capripneumoniae, is a serious OIE-listed disease affecting goats in the Middle East, north and east Africa and Asia. Mortality and morbidity rates can be as high as 60% and 90%, respectively, when the disease first enters a territory, invariably through carrier animals. Recent detections of CCPP in Pakistan and Tajikistan are probably the result of improved diagnosis as the disease has been suspected there for many years, while those in Thrace in 2003 and Mauritius in 2009 represent new outbreaks. CCPP was thought to be highly host specific until recent outbreaks in wildlife species including gazelles and gerenuks show that the causative mycoplasma has broader specificity. Diagnosis was hampered by the fastidiousness of the causative mycoplasma but molecular-based tests like PCR have greatly improved detection. Rapid latex agglutination tests that can be performed at the penside are also available for antibody detection. Clinically affected animals respond to a range of antibiotics although it is unlikely that this results in complete elimination of the mycoplasma. Vaccines consisting of saponized organisms have been shown to be protective but the quality and efficacy may be variable.

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Co-occurrence of contagious caprine pleuropneumonia and pasteurellosis in goats of sub-Saharan region: systematic review

Lukeye,

Mwanga,

Mzula

et al. 2024

Trop Anim Health Prod

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Studies on strains of Mycoplasma capricolum subsp. capripneumoniae isolated from outbreaks of contagious caprine pleuropneumonia in Eritrea

Cited by 6 publications

References 14 publications

<i>Mycoplasma capricolum</i> subsp. <i>capripneumoniae</i>, the cause of contagious caprine pleuropneumonia, comprises two distinct biochemical groups

<i>Mycoplasma capricolum</i> subsp. <i>capripneumoniae</i>, the cause of contagious caprine pleuropneumonia, comprises two distinct biochemical groups

Contagious Caprine Pleuropneumonia: New Aspects of an Old Disease

Co-occurrence of contagious caprine pleuropneumonia and pasteurellosis in goats of sub-Saharan region: systematic review

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