Studies on the Aetiology of the Sprue Syndrome

Secretory response of the human pancreas to continuous intravenous infusion of pancreozymin-cholecystokinin (Cecekin).

“…with alcoholic cirrhosis, may have had mild chronic pancreatitis since this condition is associated with hepatic cirrhosis (Pollack and Gerber, 1943) and the low output in C.B., with diabetes mellitus, has also been described in this disease by other workers (Chey, Shay, and Shuman, 1963). The low amylase output in two patients with untreated adult coeliac disease and a patient with tropical sprue in remission are of some interest in view of previous reports of normal pancreatic function in these patients (Frazer, 1952;Dreiling, 1953;Cooke, Peeney, and Hawkins, 1953). However, the pancreatic zymogen content (Gillman and Gillman, 1951) and duodenal amylase concentration in malnourished patients are both reduced (Thompson and Trowell, 1952;Gomez, Galvan, Cravioto, and Frenk, 1954) and this may have been the explanation for the low maximum amylase output in our patients.…”