Studies on the anti-asthmatic and antitussive properties of aqueous leaf extract of Bryophyllum pinnatum in rodent species

Salami, Edward O; Ozolua, Raymond I.; Okpo, Stephen O; Eze, Gerald Ikechi; Uwaya, Dickson O

doi:10.1016/s1995-7645(13)60067-x

Cited by 22 publications

(14 citation statements)

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“…In addition, aqueous leaf extracts possessed an antiasthmatic effect by successfully protecting guinea pigs from histamine-induced preconvulsive dyspnea. The reduction of coughing bouts in guinea pigs treated with this extract confirmed its antitussive properties [52]. Mice receiving daily oral treatment with B. pinnatum aqueous leaf extracts during a 14-day sensitization (ovalbumin, OVA) period were protected from fatal anaphylactic shock.…”

Section: Antioxidant Activitymentioning

confidence: 52%

“…In Trinidad and Tobago, they are used to treat several diseases and afflictions, such as hypertension and kidney and urinary disorders [51]. Herbalists in Nigeria use an aqueous leaf extract for the treatment of cough and in the prophylaxis of asthma [52]. In India, the leaves are employed as a hepatoprotective herb to treat jaundice [53], and have also been recommended for the treatment of wounds, bruises, and insect bites [54,55].…”

Section: Miscellaneous Metabolitesmentioning

confidence: 99%

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Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

et al. 2016

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ReviewsThis document was downloaded for personal use only. Unauthorized distribution is strictly prohibited.Bryophyllum (see below) [4]. While these reviews describe various compounds and bioactivities, none of them addresses the pharmacological and clinical data that support the therapeutic use of Bryophyllum preparations in European countries. The present review focuses on B. pinnatum, but the few data available on Bryophyllum daigremontianum, Bryophyllum delagoense, and the hybrid Bryophyllum daigremontianum x tubiflorum have also been included. The German homeopathic pharmacopeia (HAB) 2014 [5] lists the two species B. pinnatum and B. daigremontianum as officinal in its monography "Bryophyllum Rh", and both have been used in AM. B. delagoense was introduced in the 1980s as an anthroposophic medicinal product in Germany, primarily for sedative purposes (Personal communication, Dr. med. Siegward-M. Elsas, see Acknowledgments). Botany

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Section: Antioxidant Activitymentioning

confidence: 52%

Section: Miscellaneous Metabolitesmentioning

confidence: 99%

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

et al. 2016

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“…The whole aerial parts and juice are used externally to treat inflammation, allergies, and different skin disorders (Nassis et al 1992;Ojewole 2005;Nayak et al 2010). Kalanchoe extracts are also a popular internal remedy for stomach ulcers (Pal and Chaudhuri 1991), asthma (Salami et al 2013), infections (Willcox and Bodeker 2004), tumours (Supratman et al 2001), and regulation of blood sugar (Ojewole 2005;Majaz et al 2011;Khooshbu and Ansari 2019). A wide range of ethnomedical applications of Kalanchoe are linked to the chemical composition.…”

Section: Introductionmentioning

confidence: 99%

“…Kalanchoe extracts are also a popular internal remedy for stomach ulcers (Pal and Chaudhuri 1991 ), asthma (Salami et al. 2013 ), infections (Willcox and Bodeker 2004 ), tumours (Supratman et al. 2001 ), and regulation of blood sugar (Ojewole 2005 ; Majaz et al.…”

Section: Introductionmentioning

confidence: 99%

Biological activities of leaf extracts from selected Kalanchoe species and their relationship with bufadienolides content

Stefanowicz–Hajduk

Hering

Gucwa

et al. 2020

Pharmaceutical Biology

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Context: Kalanchoe species (Crassulaceae) are widely used in traditional medicine as remedies in infectious diseases and cancer treatment. Objective: Cytotoxic and antimicrobial activities of Kalanchoe daigremontiana Raym.-Hamet & H. Perrier, K. pinnata (Lam.) Pers., and K. blossfeldiana Poelln. extracts were determined. The relationship between biological activities and the extracts bufadienolides content was also investigated. Materials and methods: Fresh leaves of Kalanchoe species were macerated with 95% ethanol or water. The quantitative analysis of bufadienolides in the extracts was carried out with mass spectrometry. Cytotoxicity tests were performed on human cancer cell lines-HeLa, SKOV-3, MCF-7, and A375 by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay and Real-Time Cell Analysis system. The microbiological study was done using a few bacteria strains (b-hemolytic Streptococcus, Corynebacterium diphtheriae, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus hirae, Escherichia coli) and Candida albicans. Results: The K. blossfeldiana ethanol extract and K. daigremontiana water extract exhibited the most potent cytotoxic activity (IC 50 < 19 mg/mL for HeLa and SKOV-3 cells). The strongest antibacterial effects showed ethanol extract of K. blossfeldiana and K. pinnata (MIC values were 8.45, 8.45, 0.25 and <33.75 mg/mL for S. aureus, S. epidermidis, and E. hirae, respectively). The highest total amount of bufadienolides was in K. daigremontiana ethanol extract. In contrast, K. blossfeldiana ethanol extract did not show the presence of these compounds. Conclusions: Kalanchoe blossfeldiana ethanol extract is a potential candidate for cancer and bacterial infection treatment. Additionally, the biological effects of Kalanchoe extracts are not dependent on the presence and amount of bufadienolides in the plant extracts.

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“…[21], [22] 6. Bryophyllum pinnatum Flavonoid, saponin, tannin, dan alkaloid Indonesia, Taiwan [23], [24], [25][23]…”

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confidence: 99%

Berbagai Tumbuhan Obat Tradisional Di Asia Dengan Aktivitas Antiasma

Akmalia¹

2020

bimfi

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Bahan alam merupakan sumber senyawa aktif dan obat yang baik. Kajian kandungan tumbuhan sangat menarik dalam ditemukannya senyawa aktif terutama untuk terapi pada penyakit asma. Asma merupakan penyakit kronis dengan gejala mengi, sesak napas, dada sesak, dan batuk. Ada beberapa mekanisme kerja senyawa anti-asma, yaitu penghambat reseptor H1 dan H2, penurunan kadar imunoglobin E, mediator inflamasi, pencegahan sekresi sitokin Th2, dan mekanisme spesifik lainnya. Metode yang digunakan berupa tinjauan pustaka. Studi tinjauan pustaka dilakukan dengan mencari beberapa kata kunci seperti tumbuhan herbal, anti-asma, medicinal plants, antiasthmatic activity, dan lain-lain pada database elektronik termasuk ClinicalKey, Science Direct, PubMed, dan Google Scholar. Data yang diperoleh dikumpulkan, dianalisis, dan disimpulkan sehingga didapatkan data dan penjelasan tentang tumbuhan potensial yang ditemukan di seluruh Asia sebagai sumber alternatif pengobatan asma. Tiga puluh jenis tumbuhan obat tradisional di Asia yang berpotensi memiliki aktivitas anti-asma berhasil diperoleh dengan berbagai macam mekanisme kerja. Data mengenai aktivitas tumbuhan yang dikumpulkan dalam tinjauan pustaka ini menunjukkan penggunaannya sebagai bagian dari strategi pengobatan herbal alternatif dan sumber pengobatan asma.

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Studies on the anti-asthmatic and antitussive properties of aqueous leaf extract of Bryophyllum pinnatum in rodent species

Abstract: BP has demonstrated antiasthmatic and antitussive properties in these rodent models. These properties may underscore its use in Nigerian ethnomedicine.

Cited by 22 publications

References 22 publications

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

Biological activities of leaf extracts from selected Kalanchoe species and their relationship with bufadienolides content

Berbagai Tumbuhan Obat Tradisional Di Asia Dengan Aktivitas Antiasma

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