Studies on the anticoagulant action of aspilia africana

Hanna, Magdy M.; Niemetz, Julian

doi:10.1016/0049-3848(87)90455-5

Cited by 13 publications

(4 citation statements)

References 6 publications

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“…It prolonged the partial thromboplastin time, prothrombin time, thrombin, reptilase time and also decreased the fibrinogen content of plasma. The activities of coagulation factors V, VIII and IX were also found to be decreased [70].…”

Section: Aspilia Africana (Pers) C D Adamsmentioning

confidence: 96%

Medicinal Plants as Potential Sources of Lead Compounds with Anti-Platelet and Anti-Coagulant Activ

Tk¹,

Koh

2006

MRMC

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Section: Aspilia Africana (Pers) C D Adamsmentioning

confidence: 96%

Medicinal Plants as Potential Sources of Lead Compounds with Anti-Platelet and Anti-Coagulant Activ

Tk¹,

Koh

2006

MRMC

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“…Aspilia africana is widely used in ethno medical practice in Africa for its ability to stop bleeding, even from a severed artery, as well as promote rapid healing of wounds and sores and for the management of problems related to cardiovascular diseases 7 . It has also been established that Aspillia africana has an anticoagulant activities 8 . Infusion of the leaves is taken by children and can also be mixed with clay as a medicine for stomach trouble 9 .…”

Section: Introductionmentioning

confidence: 99%

Anti-Ulcer Effect Of Aspilia Africana (Asteraceae) Leaf Extract On Induced Duodenal Ulcer Of Adult Wistar Rats (Rattus Norvegicus) – A Histological Study

Eweka¹,

Eweka²

2009

IJAM

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Histological studies of the effects of oral administration of extract of Aspilia africana, used in ethno medical practice in Africa for the management of various ailments, on the duodenum of adult Wistar rats previously exposed to varied concentration of hydrochloric acid were carefully studied. The rats (n=30), average weight of 189g were randomly assigned into three treatments (n=24), 'A', 'B', 'C', each (n=8) and control (n=6), D groups. The experimental rats each received 0.5mls of 50% dilute Hydrochloric acid 48hrs prior to administration of the extract. The rats in the treatment groups 'A' and 'B' received 0.5g/kg and 1g/kg respectively of aqueous extract of Aspilia africana orally through orogastric tube for fourteen days, while the control rats (group D) received equal volume of distilled water without the extract of Aspilia added. The rats in group 'C' received only the hydrochloric acid and were sacrificed 72hrs after administration. The rats were fed with growers' mash purchased from Edo feeds and Flour Mill Ltd, Ewu, Edo state and were given water liberally. The rats were sacrificed on day fifteen of the experiment. The small intestine was carefully dissected out and quickly fixed in 10% formal saline for routine histological study after H&E method. The histological findings indicated that the treated sections of the small intestine showed varying degrees of cellular proliferation and epithelia regeneration. These findings indicate that Aspilia africana consumption may probably have anti-ulcer effects on the duodenal ulcer by its healing effects on the Brunnals gland and epithelia cells of the small intestine of adult Wistar rats. It is recommended that further studies aimed at corroborating these observations be carried out.

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“…Aspilia africana is widely used in ethno medical practice in Africa for its ability to stop bleeding, even from a severed artery, as well as promote rapid healing of wounds and sores and for the management of problems related to cardiovascular diseases 10 . It has also been established that Aspillia africana has an anticoagulant activities when applied topically to wounds 11 . Infusion of a liquid made from the leaves is taken by children and can also be mixed with clay as a medicine for stomach trouble 12 .…”

Section: Introductionmentioning

confidence: 99%

Histological Studies Of The Teratogenic Effects Of Oral Administration Of Aspilia Africana (Asteraceae) Leaf Extract On The Developing Kidney Of Wistar Rats

2008

IJTO

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Histological studies of the teratogenic effects of oral administration of extract of Aspilia africana, used in ethno medical practice in Africa for the management of various ailments, on the developing kidneys of pregnant matured female Wistar rats were studied. The rats (n=24), average weight of 180g were randomly assigned into two treatment (n=16) and a control (n=8) group. The rats in the treatment groups received 0.5g/kg and 1g/kg of aqueous extract of Aspilia africana orally through orogastric tube in the first seven days of gestation, while the control rats received equal volume of distilled water without the extract of Aspilia added. The rats were fed with growers' mash and were given water liberally. After parturition, the kidney sections were obtained from the pups or neonates and processed for routine histological investigation. Histological changes observed in the kidney sections revealed loss of renal corpuscle and varying degree of cyto-architectural distortion of the cortical structures, with degenerative and atrophic changes. This suggests the direct cytotoxic action of aqueous extract of Aspilia africana resulting from placental transfer during pregnancy to the neonates. This study highlights the possible abnormalities that could result in a newborn when a pregnant animal is exposed to an aqueous extract of Aspilia africana during the seven days of gestation. The results of this experiment suggest that the functions of the kidney could also have been affected as a result of the massive cyto-archictectural distortion. It is recommended that further studies aimed at corroborating these observations be conducted.

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Studies on the anticoagulant action of aspilia africana

Cited by 13 publications

References 6 publications

Medicinal Plants as Potential Sources of Lead Compounds with Anti-Platelet and Anti-Coagulant Activ

Medicinal Plants as Potential Sources of Lead Compounds with Anti-Platelet and Anti-Coagulant Activ

Anti-Ulcer Effect Of Aspilia Africana (Asteraceae) Leaf Extract On Induced Duodenal Ulcer Of Adult Wistar Rats (Rattus Norvegicus) – A Histological Study

Histological Studies Of The Teratogenic Effects Of Oral Administration Of Aspilia Africana (Asteraceae) Leaf Extract On The Developing Kidney Of Wistar Rats

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