Studies on the Development of a Non-genetic Obese Type 2 Diabetic Rat Model: Amelioration by (+)-Catechin Hydrate

Mehra, Pranav; Koul, Ashwani; Bansal, Devi D.

doi:10.5099/aj100400352

Cited by 2 publications

(2 citation statements)

References 38 publications

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“…Effect of high sucrose high fat diet on the development of an obese type 2 diabetic rat model has previously been studied in our laboratory [20]. In this model, persistent hyperglycemia was observed.…”

Section: Discussionmentioning

confidence: 96%

Studies on Antioxidant Role of (+)-Catechin Hydrate in High Sucrose High Fat Diet Induced Oxidative Stress

Mehra¹,

Koul²,

Bansal³

2013

Am. J. Biomed. Sci.

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In the present investigation, effect of pure green tea catechin, (+)-catechin hydrate was studied on plasma uric acid, plasma nitrite, cardiac lipid peroxidation, reduced glutathione and cardiac antioxidant enzymes in high sucrose high fat diet fed rats for a period of 12 weeks. Our results indicate that feeding high sucrose high fat diet resulted in the development of oxidative stress in rats and (+)-catchin hydrate has antioxidant effect. High sucrose high fat diet decreased plasma uric acid and increased plasma nitrite levels. Further lipid peroxidation increased and reduced glutathione levels decreased in heart of high sucrose high fat diet fed rats. Activity of antioxidant enzymes (SOD, GST, GR and GPx) was significantly reduced in high sucrose high fat fed rats. Catechin supplementation improved plasma uric acid and nitrite levels and reduced lipid peroxidation. Further there was normalization in reduced Glutathione levels and activities of cardiac antioxidant enzymes upon administration of (+)-catechin hydrate. It can be concluded that high sucrose high fat diet produces oxidative stress in rats and administration of catechin is helpful to combat oxidative stress.

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Section: Discussionmentioning

confidence: 96%

Studies on Antioxidant Role of (+)-Catechin Hydrate in High Sucrose High Fat Diet Induced Oxidative Stress

Mehra¹,

Koul²,

Bansal³

2013

Am. J. Biomed. Sci.

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“…Reduced levels of nonenzymatic low molecular weight anti-oxidants were observed in high sucrose diet fed rats [5]. Furthermore, it was recently reported that high fat and high sucrose diet causes substantial hyperglycemia and hyperlipidemia in rats [6] which may be considered responsible for contributing towards the development of oxidative stress.…”

Section: Introductionmentioning

confidence: 97%

Combined Effect of Low Magnesium and High Sucrose Diet on Magnesium Status and Nitric Oxide Production in Rats

Chaudhary¹,

Sharma²,

Bansal³

2012

Am. J. Biomed. Sci.

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Dietary magnesium deficiency as well as excess sucrose has been shown to be associated with the generation of reactive oxygen species (ROS). Nitric oxide (NO) and induction of nitric oxide synthase (NOS) are two important markers of nitrosative stress. The present study was planned to investigate the effect of low magnesium diet on magnesium status and nitric oxide production in sucrose fed rats. Male Wistar rats were divided into two groups: a control group (C); and high sucrose low magnesium diet group (HSLM). These animals were studied longitudinally over a period of three months. The urine magnesium excretion exhibited a significant decline in HSLM group. Tissue magnesium profile of various organs revealed that whereas, the magnesium content of liver, muscle and heart showed a significant decrease in the HSLM group, the magnesium content of kidneys, however, exhibit a reverse trend by showing an increase in the HSLM groups. The biochemical analysis showed a significant increase in the plasma nitrite as well as citrulline levels in the HSLM groups. These findings suggest that high sucrose and low magnesium diet may cause nitrosative stress in rats as reflected by increased production of nitric oxide and nitric oxide synthase activity.

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Studies on the Development of a Non-genetic Obese Type 2 Diabetic Rat Model: Amelioration by (+)-Catechin Hydrate

Cited by 2 publications

References 38 publications

Studies on Antioxidant Role of (+)-Catechin Hydrate in High Sucrose High Fat Diet Induced Oxidative Stress

Studies on Antioxidant Role of (+)-Catechin Hydrate in High Sucrose High Fat Diet Induced Oxidative Stress

Combined Effect of Low Magnesium and High Sucrose Diet on Magnesium Status and Nitric Oxide Production in Rats

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