Studies on the effects of monosodium glutamate on hepatic microsomal lipid peroxidation, calcium, ascorbic acid and glutathione and its dependent enzymes in adult male mice

Choudhary, Preety; Malik, Vinay; Puri, Sanjeev; Ahluwalia, Preeti

doi:10.1016/s0378-4274(96)03786-1

Cited by 30 publications

(18 citation statements)

References 22 publications

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“…The binding site of catalase have strict order of affinity for nicotinamide adenine dinucleotide (NADPH > NADH > NADP+> NAD § (24). Our findings of significant decrease in the activity of catalase in the MSG treated groups could be due to less availability of NADPH as MSG favor lipogenesis (4).…”

Section: Resultsmentioning

confidence: 58%

Studies on the effect of monosodium glutamate (MSG) administration on the activity of xanthine oxidase, superoxide dismutase and catalase in hepatic tissue of adult male mice

Singh

Ahluwalia

2002

Indian J Clin Biochem

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Subcutaneous administration of monosodium glutamate (MSG), to normal adult male mice, for six consecutive days at dose levels of 4 and 8 mg/g body weight, significantly increased the level of free radical initiating enzyme, xanthine oxidase, whereas the activity of free radical scavenging enzymes, like catalase and superoxide dismutase was significantly decreased in hepatic tissue. These observations suggested that ingestion of MSG at dose level of 4 mg/g body weight and above, induced oxidative stress in the hepatic tissue of adult male mice.

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Section: Resultsmentioning

confidence: 58%

Studies on the effect of monosodium glutamate (MSG) administration on the activity of xanthine oxidase, superoxide dismutase and catalase in hepatic tissue of adult male mice

Singh

Ahluwalia

2002

Indian J Clin Biochem

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“…MSG is toxic to the liver and kidney 11 and induces hyperlipidemia and hyperglycemia. 12,28 In addition, the daily administration of MSG significantly increased levels of malondialdehyde and 4-hydroxyalkenals in hepatic microsomes. 12 In our study, administration of BMP to mice treated with MSG exhibited a glutathionesparing effect as well as a preventive action against lipid peroxidation in mouse liver.…”

Section: Discussionmentioning

confidence: 95%

“…Meanwhile, many studies [11][12][13] showed that MSG, a flavor enhancer, induced oxidative stress in liver. However, very little work has been done on the adverse effects of MSG, especially in adults.…”

Section: Introductionmentioning

confidence: 99%

Butterbur (Petasites japonicusMax.) Extract Improves Lipid Profiles and Antioxidant Activities in Monosodiuml-Glutamate-Challenged Mice

Park

Kim

Sok

et al. 2010

Journal of Medicinal Food

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We investigated the effect of the butanol fraction from the methanol extract of butterbur (Petasites japonicus Max.) (BMP) on the plasma lipid profiles and oxidative damage of liver in mice challenged with monosodium l-glutamate (MSG). ICR mice (6-8 weeks old, male) were fed BMP (0.1% or 0.3%) for 1 week, and on day 7, MSG (4 mg/g) was administered intraperitoneally to the mice. Administration of MSG resulted in a significant decrease of antioxidant biomarkers such as total glutathione level and antioxidant enzyme activities such as glutathione reductase (GR), glutathione peroxidase (GPx), glutathione S-transferase (GST), and quinone reductase (NQO1), whereas the thiobarbituric acid-reactive substances (TBARS) value was increased in liver tissue. However, BMP supplementation markedly enhanced the hepatic antioxidant enzyme activities, including GPx, GR, GST, and NQO1, whereas it lowered TBARS, compared to the MSG-treated group. Moreover, BMP supplementation decreased total cholesterol, atherogenic index, and low-density lipoprotein-cholesterol, compared to the MSG-treated group. Based on these results, it was proposed that BMP improve the plasma lipid profiles and decrease the oxidative stress by up-regulating the hepatic antioxidant enzymes in mice challenged with MSG.

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“…all containing Monosodium glutamate (MSG) is increasing tremendously especially in Indian younger generation. Previously, we have reported that MSG induces hyperlipidemia, hyperglycemia and oxidative stress in blood, erythrocyte, liver and heart, a well known risk factor for atherosclerosis (Ahluwalia et al 1996;Choudhary et al 1996;Kuldip and Ahluwalia 2002, 2003, 2005.…”

Section: Introductionmentioning

confidence: 99%

Alteration in Serum Homocysteine Levels upon Ingestion of Monosodium Glutamate (MSG) to Adult Male Rats

Sharma

Singh

Ahluwalia

et al. 2009

Journal of Life Sciences

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The study was conducted to evaluate the alterations in serum homocysteine levels upon ingestion of monosodium glutamate at the dose levels of 4 mg and 8 mg per gram body weight for consecutive 7 days. A study revealed a significant increase in serum homocysteine levels by 27.06% (p<0.01) and 73.98% (p<0.001) in 4 mg monosodium glutamate per gram body weight ( Group-2) and 8 mg per gram body weight monosodium glutamate (Group-3) treated animals compared to normal animals. These observations suggested that ingestion of monosodium glutamate at dose level of 4 mg/g body weight and 8 mg/g body weight produced hyperhomocysteinemia and thereby could initiate atherothrombosis.

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Studies on the effects of monosodium glutamate on hepatic microsomal lipid peroxidation, calcium, ascorbic acid and glutathione and its dependent enzymes in adult male mice

Cited by 30 publications

References 22 publications

Studies on the effect of monosodium glutamate (MSG) administration on the activity of xanthine oxidase, superoxide dismutase and catalase in hepatic tissue of adult male mice

Studies on the effect of monosodium glutamate (MSG) administration on the activity of xanthine oxidase, superoxide dismutase and catalase in hepatic tissue of adult male mice

Butterbur (Petasites japonicusMax.) Extract Improves Lipid Profiles and Antioxidant Activities in Monosodiuml-Glutamate-Challenged Mice

Alteration in Serum Homocysteine Levels upon Ingestion of Monosodium Glutamate (MSG) to Adult Male Rats

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