Studies on the efficacy of cholecalciferol and derivatives for stimulating phytate utilization in broilers

Abstract

Studies were conducted to determine the effect of dietary supplementation with cholecalciferol (D3), 1,25-dihydroxycholecalciferol [1,25-(OH)2D3], 1alpha-hydroxycholecalciferol (1alpha-OHD3), and 25-hydroxycholecalciferol (25-OHD3) on utilization of phytate P by broiler chickens. Three experiments were conducted with corn-soybean meal type diets with D3 and 1,25-(OH)2D3 being tested in one experiment and 1,25-(OH)2D3, 1alpha-OHD3, and 25-OHD3 being tested in two experiments of exactly the same design. In the first experiment, high levels of D3 (110 microg and 220 microg/kg of diet) increased phytate P utilization, but the increase was not as great as that obtained from 1,25-(OH)2D3 supplementation. In the other two experiments, 1,25-(OH)2D3, D3 and 1alpha-OHD3 were consistently effective in increasing phytate P utilization as measured by plasma Ca and P, incidence of P rickets, bone ash, and retention of Ca, P, and phytate P. Supplementation with 25-OHD3 in general gave smaller and more inconsistent responses to these criteria, indicating some inconsistency in its ability to improve phytate P utilization.

Efeito da vitamina D3 e 25-hidroxi-colecalciferol sobre o desempenho, o rendimento de carcaça e a morfologia intestinal de frangos de corte¹

“…Os resultados obtidos para desempenho estão de acordo com a maioria dos estudos que envolvem vitamina D, ou seja, quando níveis de cálcio e/ou fósforo disponível estão dentro de limites de deficiência marginal ou atendendo às necessidades nutricionais, não são verificados efeitos diretos do incremento da suplementação de vitamina D (Mitchel et al, 1997;Zhang et al, 1997;Baker et al, 1998;Edwards, 2002;Fritts & Waldroup, 2005). Por outro lado, respostas mais sensíveis no desempenho são observadas em condições de redução nos níveis de cálcio e fósforo (Rao et al, 2006), podendo haver recuperação do desempenho através da otimização nos processos de absorção e metabolismo desse elementos (Nahm, 2007).…”

“…Alguns trabalhos indicam que o desempenho das aves não é afetado pela suplementação de fontes de vitamina D (Edwards, 2002;Ledwaba et al, 2003;Korver, 2005), enquanto outros (Yarger et al, 1995;Fritts & Waldroup, 2003, 2005 indicam efeito benéfico do uso do metabólito 25 OHD 3 .…”

Effect of Supplementing Plant Derived 1, 25 Dihydroxy Cholecalciferol on Performance and Bone Mineralization in Broiler Chicken Fed Suboptimal Concentrations of Calcium and Non Phytate Phosphorus

“…The enhanced P utilization with PD 1, 25 (OH) 2 D 3 could be the effective stimulation of intestinal phytase activity (Hardy and Edwards, 1993;Applegate et al, 2003) and its deposition in bones (Table 2). Similarly, Edwards (2002) observed significant (P<0.01) improvement in P retention in broiler chicken with 1, 25 (OH) 2 D 3 supplementation compared to addition of CC. Increased (P<0.05) Ca and P levels in the bone (mineralization), consequently increased (P<0.05) the bone weight and strength with substitution of CC with plant derived 1, 25 (OH) 2 D 3 with no effect of level of replacement.…”

The effects of dietary cholecalciferol and 1α-hydroxycholecalciferol levels in a calcium- and phosphorus-deficient diet on growth performance and tibia quality of growing broilers

“…Dietary vitamin D 3 (Rao et al, 2006), 1,25-(OH) 2 D 3 (Edwards, 2002), and 1α-OH D 3 Han et al, 2009) increased the serum Ca and Pi concentrations in broilers. In contrast, Driver et al (2008) reported that 1α-OH D 3 did not affect the serum Pi content in non-obese diabetic mice.…”

“…Studies have shown that vitamin D 3 (Rao et al, 2009), 1α-OH D 3 (Snow et al, 2004), 25-OH D 3 (Aburto et al, 1998) and 1,25-(OH)2 D 3 (Edwards, 2002) increase bone weight, length, and ash in broilers. These data indicate that vitamin D metabolites increase bone growth and mineral deposition in poultry.…”