Studies on the Enhanced Effect of Acupuncture Analgesia and Acupuncture Anesthesia by D-Phenylalanine (2nd Report) - Schedule of Administration and Clinical Effects in Low Back Pain and Tooth Extraction

Kitade, Toshihatsu; Odahara, Yoshinobu; Shoji, Shuichi; Ikeuchi, Takaharu; Sakai, Takao; Morikawa, Kazuhiro; Minamikawa, Masazumi; Toyota, Sumie; Kawachi, Akira; Hyodo, Masayoshi; Hosoya, Eikichi

doi:10.3727/036012990816358252

Cited by 18 publications

(11 citation statements)

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“…Lack of attenuation of nociceptive stimulation could also be explained by no or delayed release of endogenous opioid agonists. Nonetheless, increased levels of endogenous opioid agonists have been found within 20 min of low‐frequency EA stimulation (14, 15), i.e. the duration of EA or sham procedures chosen in the present and previous (1) studies.…”

Section: Discussionmentioning

confidence: 90%

Acupuncture facilitates neuromuscular and oculomotor responses to skin incision with no influence on auditory evoked potentials under sevoflurane anaesthesia

Kvorning

Christiansson

Åkeson

2003

Acta Anaesthesiol Scand

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Acupuncture facilitates neuromuscular and oculomotor responses to skin incision with no influence on auditory evoked potentials under sevoflurane anaesthesia. Link to publication Citation for published version (APA): Kvorning, N., Christiansson, C., & Åkeson, J. (2003). Acupuncture facilitates neuromuscular and oculomotor responses to skin incision with no influence on auditory evoked potentials under sevoflurane anaesthesia. Acta Anaesthesiologica Scandinavica, 47(9), 1073 -1078 . DOI: 10.1034 /j.1399 -6576.2003 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Malmö University Hospital, Lund University, Malmö, Sweden Background: More sevoflurane was recently found to be required to prevent movement in response to surgical incision in anaesthetized patients subjected to electro-acupuncture (EA) than to sham procedures. The present study was designed to compare differences in movement, dilatation of the pupils, divergence of the eye axes and activity of auditory evoked potentials (AEPs) between patients given and those not given EA under standardized sevoflurane anaesthesia. Methods: Neuromuscular, oculomotor and AEP responses to skin incision were assessed with and without a bilateral 2-Hz burst EA in patients under steady-state anaesthesia maintained with 1.8% of sevoflurane. Forty-five healthy patients, scheduled for laparoscopic sterilization, were randomized for EA (n ¼ 22) or sham (n ¼ 23) procedures between induction of anaesthesia and start of surgery. Middle latency AEP activity was recorded and interpreted by the A-line ARX (autoregression with exogenous input) index (AAI). Results: More acupuncture than sham patients were found to respond to skin incision with movement of the neck or limbs (77% vs. 43%; P ¼ 0.021), dilatation of the pupils (77% vs. 39%;

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Section: Discussionmentioning

confidence: 90%

Acupuncture facilitates neuromuscular and oculomotor responses to skin incision with no influence on auditory evoked potentials under sevoflurane anaesthesia

Kvorning

Christiansson

Åkeson

2003

Acta Anaesthesiol Scand

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“…The blood cortisol levels of the horses were significantly increased after 30 minutes of electroacupuncture treatment [13]. The release of endogenous opioids was consistent with acupuncture analgesia [12] and was potentiated by D-phenylalanine, which inhibited enkephalinase-mediated degradation of enkephalins and endorphins [14]. However, the opioid antagonist naloxone was able to reverse the effect of acupuncture analgesia in animals [15].…”

Section: Discussionmentioning

confidence: 93%

Successful Practice of Electroacupuncture Analgesia in Equine Surgery

Sheta

Ragab

Farghali

et al. 2015

Journal of Acupuncture and Meridian Studies

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Electroacupuncture analgesia was used for surgery in horses and donkeys. A KWD-808 electrical stimulator was used to incrementally induce a dense, dispersed wave output at frequencies from 20 to 55 Hz, which was maintained at a frequency of 55 Hz, and to change the amplitude of the wave to the best grading number for the suggested operation in each animal. Induction of analgesia lasted for 20-30 minutes, and the effect of analgesia was maintained for 20-45 minutes depending on the type of surgery performed. The exhibited clinical signs, physical examination data, and the responses of all animals were used for evaluating the periods of analgesia. Although the majority of the cases (95%) had no response to strong surgical pain, they experienced significant increases in heart rates and respiratory rates during induction. The lack of pain, relaxed surgical procedures, reduced intraoperative bleeding, and improved healing without complications were all definite benefits of using electroacupuncture analgesia in surgery. Thus, this study has provided surgical evidence supporting the effectiveness of electroacupuncture analgesia, as well as confirming its reliability, in the field of equine anesthesia and surgery.

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“…A neurohumoral mechanism also is supported by studies which demonstrate that human spinal cerebrospinal fluid endorphins and dynorphins increase after AP and during the period of analgesia [26]. This release of endogenous opioids coincides with AP analgesia and can be potentiated by preadministration of D-phenylalanine, which inhibits enkephalinase-mediated degradation of enkephalins and endorphins [27]. Furthermore, several studies have shown that the opioid antagonist naloxone can reverse or antagonize AP analgesia in animals [28] and humans [29].…”

Section: Neuromodulatory Mechanisms Of Ap Analgesiamentioning

confidence: 95%

Mechanisms of acupuncture analgesia: Effective therapy for musculoskeletal pain?

Staud

2007

Curr Rheumatol Rep

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Acupuncture (AP) is effective for the treatment of postoperative and chemotherapy-induced nausea/vomiting and for postoperative dental pain. Several recent randomized trials have provided strong evidence for beneficial AP effects on chronic low-back pain and pain from knee osteoarthritis. For many other chronic pain conditions, including headaches, neck pain, and fibromyalgia, the evidence supporting AP's efficacy is less convincing. AP's effects on experimental pain appear to be mediated by analgesic brain mechanisms through the release of neurohumoral factors, some of which can be inhibited by the opioid antagonist naloxone. In contrast to placebo analgesia, AP-related pain relief takes considerable time to develop and to resolve. Thus, some of the long-term effects of AP analgesia cannot be explained by placebo mechanisms. Furthermore, it appears that some forms of AP are more effective for providing analgesia than others. Particularly, electro-AP seems best to activate powerful opioid and non-opioid analgesic mechanisms.

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Studies on the Enhanced Effect of Acupuncture Analgesia and Acupuncture Anesthesia by D-Phenylalanine (2nd Report) - Schedule of Administration and Clinical Effects in Low Back Pain and Tooth Extraction

Cited by 18 publications

References 0 publications

Acupuncture facilitates neuromuscular and oculomotor responses to skin incision with no influence on auditory evoked potentials under sevoflurane anaesthesia

Acupuncture facilitates neuromuscular and oculomotor responses to skin incision with no influence on auditory evoked potentials under sevoflurane anaesthesia

Successful Practice of Electroacupuncture Analgesia in Equine Surgery

Mechanisms of acupuncture analgesia: Effective therapy for musculoskeletal pain?

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