Studies on the Epidemiology of Nontuberculous Mycobacteriosis in Japan

Tsukamura, M; Kita, N; Shimoide, H; Arakawa, Hiroshi; Kuze, A

doi:10.1164/ajrccm/137.6.1280

Cited by 110 publications

(83 citation statements)

References 3 publications

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“…Differences in geographic distribution of NTM species have been reported (16,18,19). The most commonly encountered NTM from clinical specimens in industrialized countries are M. avium complex (MAC) and M. kansasii (20)(21)(22)(23)(24).…”

Section: Discussionmentioning

confidence: 99%

Nontuberculous Mycobacteria, Zambia

Buijtels¹,

Sande²,

Graaff³

et al. 2009

Emerg. Infect. Dis.

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Clinical relevance of nontuberculous mycobacteria (NTM) isolated from 180 chronically ill patients and 385 healthy controls in Zambia was evaluated to examine the contribution of these isolates to tuberculosis (TB)-like disease. The proportion of NTM-positive sputum samples was signifi cantly higher in the patient group than in controls; 11% and 6%, respectively (p<0.05). NTM-associated lung disease was diagnosed for 1 patient, and a probable diagnosis was made for 3 patients. NTM-positive patients and controls were more likely to report vomiting and diarrhea and were more frequently underweight than the NTM-negative patients and controls. Chest radiographs of NTM-positive patients showed deviations consistent with TB more frequently than those of controls. The most frequently isolated NTM was Mycobacterium avium complex. Multiple, not previously identifi ed mycobacteria (55 of 171 NTM) were isolated from both groups. NTM probably play an important role in the etiology of TB-like diseases in Zambia.

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Section: Discussionmentioning

confidence: 99%

Nontuberculous Mycobacteria, Zambia

Buijtels¹,

Sande²,

Graaff³

et al. 2009

Emerg. Infect. Dis.

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“…In a survey from the Centers for Disease Control (CDC) in the United States (Atlanta, GA) [11,52] from 1981 to 1983, the estimated prevalence of mycobacteriosis in the United States was 1.8 per 100,000 population. A study in Japan [53] from 1981 to 1984 showed an incidence of pulmonary mycobacteriosis of 1.73 cases per 100,000 population. In 1988 we observed 0.9 cases of mycobacteriosis per 100,000 population in the canton ofZurich.…”

Section: Incidence Of Mycobacteriosismentioning

confidence: 99%

“…Despite certain geographic differences [52][53][54][55], MAC and M. kansasii represent the two clinically most important species of NTM. In the study from the CDC [52], 62% of the cases ofmycobacteriosis were associated with MAC and 24%…”

Section: Incidence Of Mycobacteriosismentioning

confidence: 99%

Epidemiology and Clinical Significance of Nontuberculous Mycobacteria in Patients Negative for Human Immunodeficiency Virus in Switzerland

Debrunner

Brändli

Graevenitz

1992

Clinical Infectious Diseases

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“…These factors augment morbidity and limit therapeutic options in such infections. NTM have been reported world wide with varying frequencies, [5][6][7][8] while in India isolation rates are between 0.7% and 34%. 9 We have reviewed the isolation rates of NTM from various clinical specimens over a period of six years at the department of Clinical Microbiology, Christian Medical College, Vellore -South India.…”

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confidence: 99%

Non tuberculous mycobacteria isolated from clinical specimens at a tertiary care hospital in South India

Mv¹,

Gladstone²

2005

Indian J Med Microbiol

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Purpose: This is a retrospective analysis of the isolation rates of nontuberculous mycobacteria (NTM) from various clinical specimens and their antimicrobial susceptibility patterns. Methods: All NTM isolated between 1999 and 2004 at Christian Medical College, Vellore, South India, were identified with various biochemical tests. Antimicrobial susceptibility test for all NTM was performed by standard methods. Results: A total of 32,084 specimens were received for culture, of which 4473 (13.9%) grew acid fast bacilli (AFB). Four thousand three hundred (96.1%) of the AFB were M. tuberculosis while 173 (3.9%) were NTM. Of the 173 NTM, 115 (66.5%) were identified to the species level. Pus, biopsy specimens and sputum specimens yielded most of the NTM of which M. chelonae (46%) and M. fortuitum (41%) accounted for majority of them. M. chelonae and M. fortuitum, showed highest susceptibility to amikacin (99.2%). NTM were repeatedly isolated from seven sputum specimens, 15 biopsy and pus specimens, two CSF and two blood cultures. Six were isolated from patients with AIDS and five from post transplant patients. Conclusions: The isolation of NTM from various clinical specimens is reported in this study to highlight the associated diseases and therapeutic options in these infections. 1 NTM comprising of over 95 species are naturally seen as saprophytes 2 but are known to cause four different categories of infections in humans such as, i) pulmonary infections resembling tuberculosis, ii) extra pulmonary infections affecting lymph nodes, skin and soft tissue, iii) multifocal disseminated infections and iv) infections in immunocompromised individuals such as AIDS and transplant patients.3 The growing population of HIV infected individuals and other immunosuppessed / immunocompromised patients coupled with better diagnostic techniques has led to an increase in the number of NTM being reported in human infections in recent years. 4 NTM produce infections more commonly in the presence of predisposing factors / underlying diseases; they are also notably resistant to commonly used antitubercular drugs. These factors augment morbidity and limit therapeutic options in such infections. NTM have been reported world wide with varying frequencies, 5-8 while in India isolation rates are between 0.7% and 34%. 9 We have reviewed the isolation rates of NTM from various clinical specimens over a period of six years at the department of Clinical Microbiology, Christian Medical College, Vellore -South India. Through this study we wish to emphasize the need to look for NTM in various clinical specimens. Materials and MethodsThis study includes the isolation of NTM from all clinical specimens from suspected pulmonary and extra pulmonary tuberculosis received between 1999 and 2004. Early morning well coughed out sputum specimens, broncho alveolar lavage, bronchial wash and endotracheal aspirate specimens were received from patients with clinical and radiological findings suggestive of pulmonary tuberculosis. From children and patients fro...

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Studies on the Epidemiology of Nontuberculous Mycobacteriosis in Japan

Cited by 110 publications

References 3 publications

Nontuberculous Mycobacteria, Zambia

Nontuberculous Mycobacteria, Zambia

Epidemiology and Clinical Significance of Nontuberculous Mycobacteria in Patients Negative for Human Immunodeficiency Virus in Switzerland

Non tuberculous mycobacteria isolated from clinical specimens at a tertiary care hospital in South India

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