Studies on the etiology, hematology, and pathology of swine dysentery

Glock, Robert Dean

doi:10.31274/rtd-180813-4088

Cited by 5 publications

(3 citation statements)

References 32 publications

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“…Previously reported electron microscopic stud- 1 Present address: Pathobiology Laboratory, National Veterinary Services Laboratory, PO Box 844, Ames, IA. ies in swine and mice have reiterated the known light microscopic findings. 2,7,17,42,43 Hemolysis is a well-known phenotypic phenomenon associated with the growth of S. hyodysenteriae on blood agar, and the ␤-hemolysin of that organism is assumed to have a role as a virulence factor in swine dysentery. 4,24,44 Most research involving the hemolysin of S. hyodysenteriae has centered on its interactions with and effects on erythrocytes.…”

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confidence: 99%

A Comparison of the Morphologic Effects ofSerpulina hyodysenteriaeor its Beta-hemolysin on the Murine Cecal Mucosa

Hutto

Wannemuehler

1999

Vet Pathol

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Abstract. Studies were carried out to compare the early morphologic changes in the cecal mucosa of mice either infected with Serpulina hyodysenteriae or exposed to the ␤-hemolysin of S. hyodysenteriae. Sixty-five 12-24-week-old C3H/HeOuJ mice were infected with S. hyodysenteriae by gastric intubation. Two mice were necropsied every hour for 30 hours following infection. S. hyodysenteriae was isolated from the cecal contents of each mouse at all time points. Macroscopic lesions were first apparent at 14 hours postinfection (PI), and light microscopic lesions were first apparent at 10 hours PI, earlier than has been previously reported. Ultrastructural changes, first evident at 6 hours PI, included disarray and loss of microvilli and terminal web, with dilatation of intercellular spaces. Luminal bacteria were translocated through epithelial cells to the lamina propria, where capillaries exhibited changes indicative of increased permeability. In another experiment, solutions containing between 2,500 and 25,000 hemolytic units of purified S. hyodysenteriae hemolysin were placed within the lumen of surgically closed murine ceca (n ϭ 10); ceca were collected for examination 3 hours following treatment. Ultrastructural changes consisted of loss of microvilli and terminal web and marked vacuolation and exfoliation of epithelial cells. Significant numbers of necrotic and apoptotic epithelial cells were present, and epithelial cells internalized moderate numbers of bacteria. The hemolysin of S. hyodysenteriae induces some of the same early ultrastructural changes in the cecal epithelium of mice as occur following infection with S. hyodysenteriae. Based on the observed bacterial translocation, luminal bacteria also appear to play a unique role in lesion development in this model.

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confidence: 99%

A Comparison of the Morphologic Effects ofSerpulina hyodysenteriaeor its Beta-hemolysin on the Murine Cecal Mucosa

Hutto

Wannemuehler

1999

Vet Pathol

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“…Also, V^. coli was shown to be present in healthy pigs Terpstra et al, 1968;Glock, 1971 andHarris et al, 1972a), casting further doubt as to whether or not V^. coli was the etiologic agent of swine dysentery.…”

Section: Literature Review Of Swine Dysentery Etiologymentioning

confidence: 99%

“…coli was the etiologic agent of swine dysentery. Terpstra et al (1968) Electron microscopy provided an insight into the causative asent when Taylor and Blakemore (1971) and Glock (1971) demonstrated a spirochete associated with the colonic tissue in affected swine. Taylor and Alexander (1971) were able to culture this organism on horse blood agar and reproduce the disease in susceptible pigs.…”

Section: Literature Review Of Swine Dysentery Etiologymentioning

confidence: 99%

Immunologic response of swine to solubilized outer envelope components of Treponema hyodysenteriae

Peterson

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Epidemiology of swine dysentery: development and evaluation of cultural and serological methods for the detection of Treponema hyodysenteriae infection

Songer

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Studies on the etiology, hematology, and pathology of swine dysentery

Cited by 5 publications

References 32 publications

A Comparison of the Morphologic Effects ofSerpulina hyodysenteriaeor its Beta-hemolysin on the Murine Cecal Mucosa

A Comparison of the Morphologic Effects ofSerpulina hyodysenteriaeor its Beta-hemolysin on the Murine Cecal Mucosa

Immunologic response of swine to solubilized outer envelope components of Treponema hyodysenteriae

Epidemiology of swine dysentery: development and evaluation of cultural and serological methods for the detection of Treponema hyodysenteriae infection

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