Studies on the fibrinolytic enzyme system in obesity

Bennett, N. B.; Ogston, C. M.; McAndrew, G. M.; Ogston, D.

doi:10.1136/jcp.19.3.241

Cited by 36 publications

(12 citation statements)

References 7 publications

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“…In contrast to our findings ofincreased levels ofanti-plasmin and the serum inhibitor of plasminogen activation in the blood of patients following acute myocardial infarction and surgical operation (Bennett, Ogston & Ogston, 1967), thelevels ofthese inhibitorswere not altered during or after the exercise stimulus used in this study. The inhibitor of activation appearing in serum differs from the anti-activator discussed above; it is absent from plasma but develops during coagulation and its characteristics suggest that its role may be primarily to allow the persistence of fibrin deposited in injured tissue during the initiation of the healing process (Bennett, 1968).…”

Section: Discussioncontrasting

confidence: 99%

The effect of prolonged exercise on the components of the blood fibrinolytic enzyme system

Bennett¹,

Ogston²,

Ogston³

1968

The Journal of Physiology

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SUMMARY1. The levels of the blood components of the fibrinolytic enzyme system were measured before, during and after a 4 hr period of exercise in eight subjects.2. Mean plasminogen activator level rose progressively over the first 3 hr with little further change during the 4th hr of exercise. Following the period of exercise there was a rise in a circulating anti-activator which was still present 20 hr after completion of the exercise.3. There was no alteration in the mean blood level of plasminogen, fibrinogen, anti-plasmin or a serum inhibitor of plasminogen activation during or following the exercise.4. The significance of the findings in relation to the mechanism of interaction of the components of the fibrinolytic system is discussed.

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Section: Discussioncontrasting

confidence: 99%

The effect of prolonged exercise on the components of the blood fibrinolytic enzyme system

Bennett¹,

Ogston²,

Ogston³

1968

The Journal of Physiology

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“…This is in accordance with Burt et al (9) and their demonstration of a lack of relationship between bodyfat and coagulation time, but at variance with the data of Goldrick (27) and others (23,51,47,5).…”

Section: University Of Toledo's Physiology Of Exercise Researchsupporting

confidence: 92%

“…Fibrinolytic activity in Australian males decreased with increasing bodyfat, while in New Guinea natives it was associated with increasing muscularity. This inverse relationship between fibrinolysis and obesity was confirmed both in European males (23,51) and females (47,5) and observed to be more profound than significant changes in various disease states (43,45,24). This same phenomenon has been recorded in Asians but not in lean Africans with a narrow range of skinfolds (50).…”

Section: Introductionmentioning

confidence: 55%

A study of platelet Count, body fat and Harvard Step Test Score

Marley¹,

Linnerud²

1973

Br J Sports Med

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The relationship between platelet count, bodyfat, and Harvard step test score was examined in 15 post-absorptive male subjects. Subjects rested for five minutes at the beginning of the testing period. A fingertip blood sample was then obtained and the platelet count determined by the method of Brecher and Cronkite. One-percent ammonium oxalate was employed as the dilution fluid. Bodyfat was calculated with the Siri formula on the basis of skinfolds obtained by the method of Pascale. Testing was concluded with the Harvard step test in a controlled environment room. Pearson product-moment correlation calculations yielded no significant relationship (P =>.05) between platelet count and bodyfat or platelet count and Harvard step test score. Subjects were equated by age matching into lean (under 9.9%), average (10-14.9%), and overweight (above 15%) bodyfat groups. An analysis of variance (ANOVA) revealed no significant difference (P > .05) between the platelet counts of these groups.

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“…Matching for sex, age and BMI was necessary since these variables are thought to influence plasma fibrinogen concentration [15,16] and might, therefore, affect fibrinogen synthesis. To standardize smoking habits, smokers were asked to refrain from smoking for 1 h before measurements were made.…”

Section: Methodsmentioning

confidence: 99%

Effects of smoking and abstention from smoking on fibrinogen synthesis in humans

et al. 2001

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Cigarette smoking and hyperfibrinogenaemia are both significant risk factors for the development of cardiovascular disease. Two studies are described here which aimed to establish the metabolic mechanism responsible for the raised plasma fibrinogen concentration observed in smokers. Chronic smokers had a significantly elevated absolute rate of fibrinogen synthesis (ASR) compared with non-smokers (22.7 +/- 1.3 mg/kg per day versus 16.0 +/- 1.3 mg/kg per day; means +/- S.E.M., P < 0.01), with plasma levels of fibrinogen significantly correlated with fibrinogen synthesis (r = 0.65, P = 0.04). Unlike fibrinogen, plasma albumin concentrations were lower in smokers than in non-smokers (45 +/- 0.4 versus 47 +/- 0.7 g/l, P < 0.05), but there was no difference in rates of albumin synthesis between the two groups. Two weeks cessation from smoking by previously chronic smokers was associated with a rapid and marked fall in plasma fibrinogen concentration (from 3.06 +/- 0.11 g/l to 2.49 +/- 0.14 g/l, P < 0.001), and a significant reduction in ASR (a 33% reduction, from 24.1 +/- 1.7 to 16.1 +/- 1.0 mg/kg per day, P < 0.001). These studies suggest a primary role for increased synthesis in producing the hyperfibrinogenaemia associated with smoking. Moreover, abstention from smoking for a period of only 2 weeks induces a significant decrease in the rate of fibrinogen synthesis by the liver, with a concomitant reduction in the plasma fibrinogen concentration.

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Studies on the fibrinolytic enzyme system in obesity

Cited by 36 publications

References 7 publications

The effect of prolonged exercise on the components of the blood fibrinolytic enzyme system

The effect of prolonged exercise on the components of the blood fibrinolytic enzyme system

A study of platelet Count, body fat and Harvard Step Test Score

Effects of smoking and abstention from smoking on fibrinogen synthesis in humans

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