Studies on the genetic control of resistance of black hooded rats to Borna disease

Herzog, S.; Frese, K.; Rott, R.

doi:10.1099/0022-1317-72-3-535

Cited by 43 publications

(23 citation statements)

References 11 publications

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“…These results are similar to those from other experimentally infected rodents, in which antibodies were detectable from days 10 to 35 p.i. onwards, depending on rodent species, strain, immune state, and viral dose [47], [49]–[51]. Overall, antibodies were detectable in 41% (16 of 39) of the voles.…”

Section: Resultsmentioning

confidence: 99%

Intracerebral Borna Disease Virus Infection of Bank Voles Leading to Peripheral Spread and Reverse Transcription of Viral RNA

et al. 2011

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Bornaviruses, which chronically infect many species, can cause severe neurological diseases in some animal species; their association with human neuropsychiatric disorders is, however, debatable. The epidemiology of Borna disease virus (BDV), as for other members of the family Bornaviridae, is largely unknown, although evidence exists for a reservoir in small mammals, for example bank voles (Myodes glareolus). In addition to the current exogenous infections and despite the fact that bornaviruses have an RNA genome, bornavirus sequences integrated into the genomes of several vertebrates millions of years ago. Our hypothesis is that the bank vole, a common wild rodent species in traditional BDV-endemic areas, can serve as a viral host; we therefore explored whether this species can be infected with BDV, and if so, how the virus spreads and whether viral RNA is transcribed into DNA in vivo.We infected neonate bank voles intracerebrally with BDV and euthanized them 2 to 8 weeks post-infection. Specific Ig antibodies were detectable in 41%. Histological evaluation revealed no significant pathological alterations, but BDV RNA and antigen were detectable in all infected brains. Immunohistology demonstrated centrifugal spread throughout the nervous tissue, because viral antigen was widespread in peripheral nerves and ganglia, including the mediastinum, esophagus, and urinary bladder. This was associated with viral shedding in feces, of which 54% were BDV RNA-positive, and urine at 17%. BDV nucleocapsid gene DNA occurred in 66% of the infected voles, and, surprisingly, occasionally also phosphoprotein DNA. Thus, intracerebral BDV infection of bank vole led to systemic infection of the nervous tissue and viral excretion, as well as frequent reverse transcription of the BDV genome, enabling genomic integration. This first experimental bornavirus infection in wild mammals confirms the recent findings regarding bornavirus DNA, and suggests that bank voles are capable of bornavirus transmission.

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Section: Resultsmentioning

confidence: 99%

Intracerebral Borna Disease Virus Infection of Bank Voles Leading to Peripheral Spread and Reverse Transcription of Viral RNA

et al. 2011

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“…Wistar rats and black-hooded (BH) rats can be productively infected but have less severe disease than Lewis rats, a strain with a lesion in the hypothalamic±pituitary adrenal axis associated with enhanced susceptibility to immunemediated disorders such as experimental allergic encephalomyelitis and adjuvant induced arthritis [83,84]. One report found that resistance to BD was inherited as a dominant trait in Lewis and BH hybrids that was independent of MHC genes [85]. Virulence of viral strains for rats may be enhanced by serial passages of virus in rat brain [86].…”

Section: Adult Rat Modelmentioning

confidence: 98%

Borna disease virus

Jordan

Lipkin

2001

Reviews in Medical Virology

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Borna disease virus (BDV) is unique amongst animal RNA viruses in its molecular biology and capacity to cause persistent, noncytolytic CNS-infection in a wide variety of host species. Unlike other non-segmented negative-strand RNA animal viruses, BDV replicates in the nucleus of the host cell where splicing is employed for expression of a very compact genome. Epidemiological studies indicate a broad host range and geographical distribution, and some investigators have proposed that human infection may result in neuropsychiatric disorders. Experimental Borna disease in neonatal and adult rats provides an intriguing model for immune-mediated disturbances of brain development and function.

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“…(Johansson et al, 2002;Katz et al, 1998). Overall, the serological response is stronger in experimentally infected than in naturally infected animals, although it is not constantly detected in either animal group (Morales et al, 1988;Herzog et al, 1991;Rubin et al, 1993;Johansson et al, 2002). As BDV antibodies can only be found in the sera of 30-40 % of verified, infected animals, seroprevalences are clearly an underestimate of the existing BDV infections.…”

Section: Infection Kinetics and Diagnosis Of Bdv Infectionsmentioning

confidence: 99%

Epidemiology and host spectrum of Borna disease virus infections

Kinnunen

Palva

Vaheri

et al. 2013

Journal of General Virology

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Borna disease virus (BDV) has gained lot of interest because of its zoonotic potential, ability to introduce cDNA of its RNA transcripts into host genomes, and ability to cause severe neurobehavioural diseases. Classical Borna disease is a progressive meningoencephalomyelitis in horses and sheep, known in central Europe for centuries. According to current knowledge, BDV or a close relative also infects several other species, including humans at least occasionally, in central Europe and elsewhere, but the existence of potential ‘human Borna disease’ with its suspected neuropsychiatric symptoms is highly controversial. The recent detection of endogenized BDV-like genes in primate and various other vertebrate genomes confirms that at least ancient bornaviruses did infect our ancestors. The epidemiology of BDV is largely unknown, but accumulating evidence indicates vectors and reservoirs among small wild mammals. The aim of this review is to bring together the current knowledge on epidemiology of BDV infections. Specifically, geographical and host distribution are addressed and assessed in the critical light of the detection methods used. We also review some salient clinical aspects.

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Studies on the genetic control of resistance of black hooded rats to Borna disease

Cited by 43 publications

References 11 publications

Intracerebral Borna Disease Virus Infection of Bank Voles Leading to Peripheral Spread and Reverse Transcription of Viral RNA

Intracerebral Borna Disease Virus Infection of Bank Voles Leading to Peripheral Spread and Reverse Transcription of Viral RNA

Borna disease virus

Epidemiology and host spectrum of Borna disease virus infections

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