DOI: 10.1159/000391720
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Studies on the Hamster Papilloma and the Hamster Virus Lymphoma

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Cited by 21 publications
(23 citation statements)
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“…wt. of -3.1 x 106 have been isolated from homogeneous preparations of virus obtained from the primary skin epithelioma (Graffi et al, 1970). A preliminary characterization of this DNA has established that distinct homologies exist with polyoma and to a lesser extent with SV40 genomes (Scherneck et al, 1984), despite totally divergent restriction maps.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…wt. of -3.1 x 106 have been isolated from homogeneous preparations of virus obtained from the primary skin epithelioma (Graffi et al, 1970). A preliminary characterization of this DNA has established that distinct homologies exist with polyoma and to a lesser extent with SV40 genomes (Scherneck et al, 1984), despite totally divergent restriction maps.…”
Section: Introductionmentioning
confidence: 99%
“…Interestingly, both the virus and its DNA are capable of inducing lymphomas and leukemias when inoculated subcutaneously into newborn hamsters; the incidence is high (30-80 %) and the latency short (4-8 weeks). Thymectomized animals are poorly susceptible to these induced diseases suggesting that T lymphocytes may be the target of infection (Graffi et al, 1970). Virions have not been detected in the lymphoma or leukemia cells.…”
Section: Introductionmentioning
confidence: 99%
“…
IN an earlier communication we reported on multiple epithelial skin tumours in Syrian hamsters in which a Papova virus has been detected with great regularity, in large quantities, and in characteristic histological distribution, as evidenced by electron microscopic observation (Graffi et al, 1967). In experiments designed to transmit this disease by means of subcellular extracts from these tumours to other animals we surprisingly obtained in Syrian hamsters and, in certain circumstances, also in rats, leukoses and reticuloses.
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mentioning
confidence: 84%
“…Virus-induced tumours of stratified squamous-cell epithelium, such as plantar warts in man and papillomas in Syrian hamsters (Graffi et al, 1970) are benign and tend to regress. Perhaps more comparable, as the oral mucosa is involved, is multiple papillomatosis of the tongue in rabbits, but again these tumours are benign and always regress (Weisbroth, 1974).…”
Section: Pathoyenesismentioning
confidence: 99%