Studies on the inhibition of D-alanyl-D-alanine synthetase by the antibiotic D-cycloserine

Neuhaus, Francis C.; Lynch, Judy L.

doi:10.1016/0006-291x(62)90011-6

Cited by 31 publications

(21 citation statements)

References 8 publications

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“…These results are quite similar to those produced by the deletion of alanine from the insect's completely defined diet (Tsiropoulos, 1983). This analogue is a natural substance with antibiotic properties and has been found to interfere with alanine metabolism, affecting bacterial development (Neuhaus & Lynch, 1962). As in B. oleae, alanine can be synthesized by symbiotic bacteria (Tsiropoulos, 1989), Dcycloserine may actually inhibit activity of the microflora, with a final negative result in the fly's nutritional metabolism.…”

Section: Discussionmentioning

confidence: 99%

Survival, fecundity and fertility of Bactrocera oleae, as affected by amino acid analogues

Zografou

Tsiropoulos

Margaritis³

1998

Entomologia Exp Applicata

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The effect of twenty five amino acid analogues at various concentrations upon the adult olive fruit fly Bactrocera oleae Gmelin (Diptera: Tephritidae), was tested. Insect survival was significantly shortened by the following amino acid analogues: (in parentheses are indicated the antagonized amino acids) D‐cycloserine (alanine), L‐glutamic acid‐γ‐hydrazide (glutamine), DL‐allyl‐glycine (cysteine), L‐canavanine (arginine), L‐methionine‐DL‐sulfoximine (methionine) and 3,4‐dehydro‐DL‐proline (proline). Fecundity was significantly reduced by the same analogues plus aminoethanesulfonic acid (glycine), taurine (alanine), L‐norvaline (leucine), a‐methyl‐DL‐serine (serine), DL‐hydroxyglutamic acid (glutamic acid), (S)‐2‐(aminoethyl)‐L‐cysteine (lysine), a‐methyl‐DL‐methionine (methionine) and a‐methyl‐DL‐histidine (histidine). All the above amino acid analogues also depressed egg‐hatching with the exception of taurine, DL‐hydroxyglutamic acid, DL‐allyl glycine, a‐methyl‐DL‐methionine and a‐methyl‐DL‐histidine. Finally, y‐glutamyl‐p‐nitroanilide (glutamic acid), crotyl‐glycine (methionine), DL‐7‐azatryptophan and 5‐methyl‐DL‐tryptophan (tryptophan), DL‐1,2,4 triazole‐3‐alanine (histidine) and DL‐pipecolic acid (proline) did not affect any of the parameters tested.

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Section: Discussionmentioning

confidence: 99%

Survival, fecundity and fertility of Bactrocera oleae, as affected by amino acid analogues

Zografou

Tsiropoulos

Margaritis³

1998

Entomologia Exp Applicata

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“…D-cycloserine (D-4-amino-isoxazolidone) and ampicillin. D-cycloserine is an antibiotic which inhibits enzymes involved in D-alanine metabolism and can cause cell lysis [31,32]. Ampicillin is an antibiotic which inhibits the transpeptidase responsible for crosslinking peptidoglycan and can also cause cell lysis [33].…”

Section: Improving Texture Of Fermented Milkmentioning

confidence: 99%

The art of strain improvement of industrial lactic acid bacteria without the use of recombinant DNA technology

et al. 2014

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The food industry is constantly striving to develop new products to fulfil the ever changing demands of consumers and the strict requirements of regulatory agencies. For foods based on microbial fermentation, this pushes the boundaries of microbial performance and requires the constant development of new starter cultures with novel properties. Since the use of ingredients in the food industry is tightly regulated and under close scrutiny by consumers, the use of recombinant DNA technology to improve microbial performance is currently not an option. As a result, the focus for improving strains for microbial fermentation is on classical strain improvement methods. Here we review the use of these techniques to improve the functionality of lactic acid bacteria starter cultures for application in industrial-scale food production. Methods will be described for improving the bacteriophage resistance of specific strains, improving their texture forming ability, increasing their tolerance to stress and modulating both the amount and identity of acids produced during fermentation. In addition, approaches to eliminating undesirable properties will be described. Techniques include random mutagenesis, directed evolution and dominant selection schemes.

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“…( 2 ) D-and L-cycfoserine The argument concerning the mode of action of cycloserine has continued since the article was written (see p. I 12). A full account of the action of D-cycloserine as a competitive inhibitor of D-alanyl-D-alanine synthetase in Streptococcus faecalis has now appeared (Neuhaus & Lynch, 1964) and it seems absolutely clear that D-cycloserine may act as a competitive inhibitor at both of the enzymic steps involved in the synthesis of D-alanyl-D-alanine. This is in close agreement with the fact that the bacterial growth inhibitory effect of D-cycloserine is easily reversible with u-alanine (Serembe, 1957).…”

Section: Is Addendum ( I ) L-ma-serinementioning

confidence: 99%

Addendum

1965

Biological Reviews

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Studies on the inhibition of D-alanyl-D-alanine synthetase by the antibiotic D-cycloserine

Cited by 31 publications

References 8 publications

Survival, fecundity and fertility of Bactrocera oleae, as affected by amino acid analogues

Survival, fecundity and fertility of Bactrocera oleae, as affected by amino acid analogues

The art of strain improvement of industrial lactic acid bacteria without the use of recombinant DNA technology

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