Studies on the Interaction of Ca<sup>2+</sup>Ions with Some Fractions of the Neurospecific S‐100 Protein

Starostina, M. V.; Malup, T. K.; Sviridov, S. M.

doi:10.1111/j.1471-4159.1981.tb10814.x

Cited by 12 publications

(4 citation statements)

References 24 publications

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“…Our data on the effects of A-S-100 in "high" concentrations coincide completely with those obtained earlier at our laboratory (9) and by other authors (3,(10)(11)(12). Ability of A-S-100 to change the excitability of neuronal membrane and to block LTP induction is probably due to the blockage of functional activity of S-100 proteins taking part in regulation of various calcium-depending processes in nervous tissue (13,14).…”

Section: Discussionsupporting

confidence: 91%

“…Monospecific antiserum to S-100 protein (A-S-100) and non-immune rabbit serum were a generous gift of Dr. S.M.Sviridov. Procedures of S-100 purification and antiserum preparation were described earlier (3). Low concentrations of antibodies were produced using a routine method for homeopathic drugs by «Materia medica» company staff.…”

Section: Experimental and Control Serummentioning

confidence: 99%

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Membrane and synaptic effects of anti-s-100 are prevented by the same antibodies in low concentrations

Beregovoy²,

Ns³

et al. 2003

Front Biosci

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Effects of antiserum to S-100 protein (AS-100) in high (HC, corresponding to antiserum dilution 1:5 - 1:50) and low (LC, 1:10(12)) concentrations were studied in identified snail neurons and rat hippocampal slices. HC-AS-100 changed the frequency of action potential generation in spontaneously active neurons and blocked formation of long-term potentiation in mossy fiber synapses. LC-AS-100 alone did not affect any characteristic measured in our experiments, but 20 min pre-incubation of snail ganglia or hippocampal slices with LC-AS-100 abolished the effects of the same antibodies in HC. Simultaneous addition of both LC and HC did not prevent the development of HC-AS-100 effects. It seems possible that LC-AS-100 is capable of interaction with neuronal cells modifying their reaction to HC-AS-100.

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Section: Discussionsupporting

confidence: 91%

Section: Experimental and Control Serummentioning

confidence: 99%

Membrane and synaptic effects of anti-s-100 are prevented by the same antibodies in low concentrations

Beregovoy²,

Ns³

et al. 2003

Front Biosci

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“…Antibodies to S-100B were isolated from the serum on columns with S-100B protein immobilized on CNBr-sepharose (17,18). The immunoglobulin solution was dialyzed against 0.15 M NaCl and concentrated using ultrafiltration.…”

Section: Methodsmentioning

confidence: 99%

Improvement of Memory by Means of Ultra‐Low Doses of Antibodies to S‐100B Antigen

Epstein

Pavlov

Штарк

2006

Evidence-Based Complementary and Alternative Medicine

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Antigen S-100B of nervous tissue, according to the data of numerous studies, affects the mechanisms of nervous system plasticity and memory. The influence of ultralow doses of antibodies to S-100B (6C dilution, according to the homeopathic pharmacopoeia) has been studied on three learning behavioral models on Wistar rats, which were inhibitory avoidance, choosing of bowls with sucrose and feeding behavior cessation after auditory signal. For all three tasks, parameters of reproduction of the learned skills improved after per oral administration of potentiated antibodies to S-100B antigen immediately after learning. Possible mechanisms of the anti-S-100B antibodies influence on memory formation are discussed.

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“…S100A contains and units; S100B contains two units. Procedures of S100 purification and antibody preparation have been described previously (Starostina et al 1981). All dilutions were prepared in glass vials.…”

Section: Elevated Plus-maze Test In the Ratmentioning

confidence: 99%

Antibodies to S100 proteins have anxiolytic-like activity at ultra-low doses in the adult rat

Castagné

Lemaire

Kheyfets³

et al. 2008

Journal of Pharmacy and Pharmacology

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S100 proteins are small calcium-binding proteins interacting with numerous intra- and extra cellular targets involved in diverse physiological functions. In particular, S100 proteins may be involved in the regulation of anxiety-related behaviour. In the present study, the effects of affinity-purified antibodies to S100 proteins administered orally at ultra-low doses were evaluated in pre-clinical tests for anxiolytic-like activity in the adult rat. In the Vogel conflict test in the rat, antibodies to S100 proteins increased punished drinking (anti-conflict effect) at 5 and 7.5 mL kg(-1), but not at 2.5 or 10 mL kg(-1). Antibodies to S100 proteins increased the percentage of entries into the open arms of an elevated plus-maze at 10 mL kg(-1), but not at lower doses. Taken together, these results indicate the presence of anxiolytic-like activity for antibodies to S100 proteins over the dose range 5-10 mL kg(-1) in the adult rat.

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Studies on the Interaction of Ca²⁺Ions with Some Fractions of the Neurospecific S‐100 Protein

Cited by 12 publications

References 24 publications

Membrane and synaptic effects of anti-s-100 are prevented by the same antibodies in low concentrations

Membrane and synaptic effects of anti-s-100 are prevented by the same antibodies in low concentrations

Improvement of Memory by Means of Ultra‐Low Doses of Antibodies to S‐100B Antigen

Antibodies to S100 proteins have anxiolytic-like activity at ultra-low doses in the adult rat

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Studies on the Interaction of Ca2+Ions with Some Fractions of the Neurospecific S‐100 Protein

Cited by 12 publications

References 24 publications

Membrane and synaptic effects of anti-s-100 are prevented by the same antibodies in low concentrations

Membrane and synaptic effects of anti-s-100 are prevented by the same antibodies in low concentrations

Improvement of Memory by Means of Ultra‐Low Doses of Antibodies to S‐100B Antigen

Antibodies to S100 proteins have anxiolytic-like activity at ultra-low doses in the adult rat

Contact Info

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Studies on the Interaction of Ca²⁺Ions with Some Fractions of the Neurospecific S‐100 Protein