Studies on the mechanism of anti-inflammatory and anti-ulcer activity of - probable involvement of 5-lipooxygenase pathway

Sen, Tuhinadri; Ghosh, Tanmay; Chaudhuri, Arabinda

doi:10.1016/0024-3205(93)90236-v

Cited by 43 publications

(21 citation statements)

References 19 publications

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“…In this study, the proliferation and migration of oral mucosal cells treated with Pluchea indica extract and NPs containing Pluchea indica leaf extract were assessed to investigate the in vitro wound healing properties. The anti-inflammatory, anti-nociceptive, antituberculosis and antioxidant activities of Pluchea indica leaf ethanol extract were reported (Sen et al 1993;Mohamad et al 2011;Buapool et al 2013;Suriyaphan 2014). In Asian traditional medicines, a poultice of leaves is applied externally on top of the wound to treat ulcers and sooth sores (Wiart 2006).…”

Section: Discussionmentioning

confidence: 99%

Wound healing activity of Pluchea indica leaf extract in oral mucosal cell line and oral spray formulation containing nanoparticles of the extract

Buranasukhon

Athikomkulchai

Tadtong

et al. 2017

Pharmaceutical Biology

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Context: Pluchea indica (L.) Less (Asteraceae) is an herb used as a traditional medicine for wound healing. The chemical compounds found in Pluchea indica leaves are phenolic acids, flavonoids, anthocyanins and carotenoids.Objective: This study investigates the effect of Pluchea indica leaf ethanol extract and its nanoparticles (NPs) on cytotoxicity, cell survival and migration of human oral squamous carcinoma cell line. Materials and methods: Cell viability was measured using MTT assay to assess the effect of Pluchea indica leaf extract and NPs (1-500 lg/mL) on cytotoxicity and cell survival. The effect of Pluchea indica leaf extract and NPs on cell migration was determined by scratch assay. The % relative migration was calculated after 24, 48 and 72 h of treatment.Results: The sizes of Pluchea indica leaf extract NPs were in a range of nanometers. NPs possessed negative charge with the polydispersity index (PDI) smaller than 0.3. After the treatment for 24, 48 and 72 h, Pluchea indica leaf extract had IC 50 value of 443.2, 350.9 and 580.5 lg/mL, respectively, whereas the IC 50 value of NPs after the treatment for 24, 48 and 72 h were 177.4, 149.2 and 185.1 lg/mL, respectively. The % relative migration of cells was significantly increased when the cells were treated with 62.5 and 125 lg/mL of the extract and 62.5 lg/mL of NPs. Discussion and Conclusions: NPs increased cytotoxicity of the Pluchea indica leaf extract, increased the migration of cells at low concentration and increased colloidal stability of the extract in an oral spray formulation. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Wound healing activity of Pluchea indica leaf extract in oral mucosal cell line and oral spray formulation containing nanoparticles of the extract

Buranasukhon

Athikomkulchai

Tadtong

et al. 2017

Pharmaceutical Biology

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“…The plant is also known to be used in rheumatoid arthritis (Chatterjee, 1996). Root extract has also been evaluated for (Sen et al, 1991), antiulcer (Sen et al, 1993), and neuropharmacological (Thongpraditchote Kartick Chandra Pramanik and Tapan Kumar Chatterjee et al, 1996) actions. The hypoglycemic and antihyperglycemic activity of leaf extract of P. indica and the antioxidant activity (Sen et al, 2002) of roots of P. indica Less.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo antibacterial activities of root extract of tissue cultured Pluchea indica (L.) Less.

Pramanik¹,

Chatterjee²

2008

Oriental Pharmacy and Experimental Medicine

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SUMMARYThe methanolic root extract of tissue cultured Pluchea indica (L.) Less. was tested for its antibacterial potentiality against 102 different strains of bacteria belonging to both Gram positive and Gram negative groups. The bacteria could be arranged according to their decreasing order of sensitivity as follows: Staphylococcus aureus, Vibrio cholerae, Bacillus spp. Vibrio parahaemolyticus, shigellae, Salmonella spp., and Escherichia coli. The extract was found to be bacteriostatic in nature against Salmonella typhimurium NCTC 74. When administered to Swiss strain of white mice at the doses of 0.5 and 1.0 mg/kg body weight, the extract could significantly protect the animals challenged with 50 MLD of S. typhimurium NCTC 74. According to the chi-square test, the in vivo data is highly significant (P < 0.001).

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“…In addition, the methanolic fraction of a chloroform extract of roots from Pluchea indica showed anti-ulcer and anti-inflammatory activities as well as the inhibition of protein exudation and leukocyte migration through the involvement of the 5-lipoxigenase pathway (Sen and Nag-Chaudhuri, 1991;Sen et al, 1993). Pharmacological studies demonstrated that aqueous and dichloromethane extracts obtained from Pluchea sagittalis have a wide spectrum of anti-inflammatory activity, correlating with the reduction of free radicals (Pérez-Garcia et al, 1996).…”

Section: Introductionmentioning

confidence: 97%

Antinociceptive and gastroprotective actions of ethanolic extract from Pluchea sagittalis (Lam.) Cabrera

Figueredo

Nascimento

Freitas

et al. 2011

Journal of Ethnopharmacology

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Studies on the mechanism of anti-inflammatory and anti-ulcer activity of - probable involvement of 5-lipooxygenase pathway

Cited by 43 publications

References 19 publications

Wound healing activity of Pluchea indica leaf extract in oral mucosal cell line and oral spray formulation containing nanoparticles of the extract

Wound healing activity of Pluchea indica leaf extract in oral mucosal cell line and oral spray formulation containing nanoparticles of the extract

In vitro and in vivo antibacterial activities of root extract of tissue cultured Pluchea indica (L.) Less.

Antinociceptive and gastroprotective actions of ethanolic extract from Pluchea sagittalis (Lam.) Cabrera

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