Studies on the mechanisms of L-dopa-induced depletion of 5-hydroxytryptamine in the mouse brain

Wuerthele, Suzanne M.; Moore, Kenneth E.

doi:10.1016/0024-3205(77)90342-3

Cited by 16 publications

(4 citation statements)

References 19 publications

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“… 28 PD-associated L-dopa depletion. 29 – 39 PD associated with L-tryptophan depletion. 31 , 32 L-dopa-associated L-tyrosine depletion.…”

Section: Introductionmentioning

confidence: 99%

Parkinson’s disease managing reversible neurodegeneration

Hinz¹,

Stein²,

Cole³

et al. 2016

NDT

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Traditionally, the Parkinson’s disease (PD) symptom course has been classified as an irreversible progressive neurodegenerative disease. This paper documents 29 PD and treatment-induced systemic depletion etiologies which cause and/or exacerbate the seven novel primary relative nutritional deficiencies associated with PD. These reversible relative nutritional deficiencies (RNDs) may facilitate and accelerate irreversible progressive neurodegeneration, while other reversible RNDs may induce previously undocumented reversible pseudo-neurodegeneration that is hiding in plain sight since the symptoms are identical to the symptoms being experienced by the PD patient. Documented herein is a novel nutritional approach for reversible processes management which may slow or halt irreversible progressive neurodegenerative disease and correct reversible RNDs whose symptoms are identical to the patient’s PD symptoms.

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“… 28 PD-associated L-dopa depletion. 29 – 39 PD associated with L-tryptophan depletion. 31 , 32 L-dopa-associated L-tyrosine depletion.…”

Section: Introductionmentioning

confidence: 99%

Parkinson’s disease managing reversible neurodegeneration

Hinz¹,

Stein²,

Cole³

et al. 2016

NDT

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“…L-DOPA will almost inevitably stimulate noradrenaline synthesis as well as that of dopamine, making interpretation of the results thus obtained far from clear. Moreover, high doses of 1-DOPA can displace serotonin from central nervous storage sites, thereby impeding serotonergic activity (Bartholini et al, 1968;Wuerthele and Moore, 1977). In a study where 1-DOPA was found to stimulate male-to-male mounting behavior, evidence was presented showing that this effect was mainly due to serotonindepletion (da Prada et al, 1973).…”

Section: Discussionmentioning

confidence: 97%

Dopamine and sexual behavior in the male rat: a reevaluation

Ågmo

Fernández

1989

J. Neural Transmission

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In castrated male rats treated with a low dose of testosterone propionate (0.40 mg/kg per week), the dopamine agonists amphetamine and amfonelic acid reduced mount latency without affecting other aspects of sexual behavior. Apomorphine, in doses between 0.05 and 0.15 mg/kg, and 1-DOPA 5-45 mg/kg + carbidopa 50 mg/kg, lacked effect on sexual behavior. Both amphetamine and amfonelic acid increased locomotor activity in a dose-dependent manner. Apomorphine, in the lowest dose, produced a reduction whereas the higher doses of this drug as well as all doses of 1-DOPA lacked effect on this behavior. In castrated animals implanted with a testosterone-filled Silastic capsule, showing a level of sexual activity indistinguishable from that of intact animals, amphetamine and amfonelic acid did not affect sexual behavior. The dopamine receptor antagonists haloperidol and cis(Z)-flupentixol reduced sexual behavior, whereas pimozide was without effect in the dose range used. The doses of haloperidol and flupentixol that were required to reduce sexual activity were such that they also affected motor execution measured in a treadmill test. It is suggested that increased dopaminergic neurotransmission may stimulate sexual behavior in an indirect way, augmenting behavioral arousal. The inhibitory effects of dopamine antagonists could be explained either by a reduced arousal level or by motor deficiencies.

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“…Some investigators have proposed that 5-HT may mediate some of the behavioral effects of L -DOPA because 5-HT depletion/release occurs in the brain (Algeri & Cerletti, 1974; Everett & Borcherding, 1970; Karobath, Diaz, & Huttunen, 1971; Wuerthele & Moore, 1977) and spinal cord (Commissiong & Sedgwick, 1979) following peripheral administration of L -DOPA (but see Goldstein & Frenkel, 1971; Hollister, Breese, & Mueller, 1979). Jacobs (1974) found that part of the behavioral syndrome induced by pargyline + L -DOPA could be blocked by the 5-HT synthesis inhibitor, p -chlorophenylalanine, or the 5-HT receptor antagonists, methysergide and cinanserin.…”

Section: Discussionmentioning

confidence: 99%

L-DOPA and quipazine elicit air-stepping in neonatal rats with spinal cord transections.

McEwen¹,

Hartesveldt²,

Stehouwer³

1997

Behavioral Neuroscience

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Acute mid-thoracic spinal cord transection eliminates hindlimb air-stepping in neonatal rats suspended in harnesses and administered L-DOPA. Because spinal cord transection eliminates all descending inputs to the hindlimb locomotor circuits, this experiment determined if coadministration of L-DOPA and quipazine (serotonin receptor agonist) would induce hindlimb air-stepping in rat pups 24 hr after transection. Hindlimb steps of spinally transected pups that received L-DOPA or quipazine alone were infrequent and slow; hindlimb steps induced by L-DOPA + quipazine occurred more frequently and were faster than those elicited by either drug alone. These findings suggest that catecholaminergic and serotonergic systems both contribute to hindlimb stepping.

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Studies on the mechanisms of L-dopa-induced depletion of 5-hydroxytryptamine in the mouse brain

Cited by 16 publications

References 19 publications

Parkinson’s disease managing reversible neurodegeneration

Parkinson’s disease managing reversible neurodegeneration

Dopamine and sexual behavior in the male rat: a reevaluation

L-DOPA and quipazine elicit air-stepping in neonatal rats with spinal cord transections.

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Studies on the mechanisms of L-dopa-induced depletion of 5-hydroxytryptamine in the mouse brain

Cited by 16 publications

References 19 publications

Parkinson&rsquo;s disease managing reversible neurodegeneration

Parkinson&rsquo;s disease managing reversible neurodegeneration

Dopamine and sexual behavior in the male rat: a reevaluation

L-DOPA and quipazine elicit air-stepping in neonatal rats with spinal cord transections.

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Product

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Parkinson’s disease managing reversible neurodegeneration

Parkinson’s disease managing reversible neurodegeneration