Studies on the Miltenberger Complex Frequency in Thailand and Family Studies¹

Abstract

In studies of Thai blood donors, 243 of 2,500 subjects (9.7%) were Mi-a positive. All but two were of class Mi -II. Family studies established that Mi III is probably inherited as an autosomal dominant character and usually accompanies the Ms gene complex of the MNSs blood group system.

Frequencies and specificities of red cell alloantibodies in the Southern Thai population

“…The frequency of anti-Mi a in Central Thais was previously reported as 9.72%. [7] In this study we found that anti-Mi a was very common. The frequency of anti-Mi a varied depending on the detection technique used.…”

Expression of the Rh/RhAG complex is reduced in Mi.III erythrocytes

“…Therefore, Mi.III is considered the second most important blood group antigen following ABO. Notably, the frequency of Mi.III in Thailand is near 10% [11], indicating that this blood group antigen is also highly important in other regions of South‐east Asia.…”

Studies on Anti-Mi^a and the MiIII Complex

“…This result confirmed the finding which was first observed by Cleghorn [4] in a Chinese family and later reported by Cornwall et al [5] in a family of Portuguese Indian descent. This finding is important in the inter pretation of MNSs groups in the Thai population since the frequency of Milll is relatively high [1].…”

“…When MNSs groups of Miltenberger-positive persons found in Thailand and their relatives were determined [1,3] it was noticed that some Milll cells reacted weakly with anti-N (rabbit) but not as strongly as MN, Mi(a -) and NN, Mi(a-) controls. Further studies on these 'weak N' cells were performed.…”