Studies on the Mode of Action of Psoralen Derivatives

“…PUVA therapy (Psoralen + UVA) [174] is the most known example of this type of application and was introduced by El Mofty, who in 1948 isolated and applied 8-MOP in the treatment of the skin disease vitiligo [175]. Even today 8-MOP is the most common psoralen in human therapy, although 5-MOP, 4,8,5'-trimethylpsoralen (TMP) or psoralen itself Fig.…”

Section: E Biological Activity Of Furocoumarinsmentioning

confidence: 99%

Furocoumarins in Medicinal Chemistry. Synthesis, Natural Occurrence and Biological Activity

Santana

Uriarte

Roleira

et al. 2004

CMC

197

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The scope of this review encompasses the importance of furocoumarins and the most important developments in this field that have been made in recent years, with particular emphasis placed on the aspects related to medicinal chemistry. A concise and exhaustive overview is given regarding the methods used for the synthesis of these compounds, new furocoumarins isolated from natural sources, and the most significant biological properties associated with these molecules. The section describing the synthetic methods is organized on the basis of the key step used for the formation of the two different oxygenated rings. In this respect there are three possibilities: (i) formation of the furan ring onto the coumarin, (ii) formation of the pyrone ring onto the benzofuran and (iii) the simultaneous formation of both oxygenated rings onto a benzene unit. The most recent preparative approaches are discussed along with modifications or improvements to methods that, though not particularly new, are still commonly used. The recently discovered natural furocoumarins are focused and presented in tables that provide information about its structure and source. The discussion of the biological importance of furocoumarins mainly focuses on their more relevant applications in photochemotherapy, but also provides examples of their versatility in a range of applications in the fields of biology and pharmacology.

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“…The plant is also used to treat irregular menstruation, as a diuretic, and for the treatment of leprosy, kidney stones and urinary tract infections [ 108 ]. Clinical trials of the efficacy of Fructus Ammi Majoris (the dried ripe fruits of this species) and xanthotoxin for the treatment of vitiligo, psoriasis, and hypopigmentation tinea versicolor have proven positive [ 109 – 115 ]. Consequently, A. mujus is known to be one of the most important medicinal plants which has been used industrially for the isolation of its active principles in Egypt [ 116 ].…”

Section: Ulvaceae Umbelliferae and Urticaceaementioning

confidence: 99%

The Chemistry and Biological Activities of Natural Products from Northern African Plant Families: From Taccaceae to Zygophyllaceae

Ntie‐Kang

Njume

Malange

et al. 2016

Nat. Prod. Bioprospect.

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Traditional medicinal practices have a profound influence on the daily lives of people living in developing countries, particularly in Africa, since the populations cannot generally afford the cost of Western medicines. We have undertaken to investigate the correlation between the uses of plants in Traditional African medicine and the biological activities of the derived natural products, with the aim to validate the use of traditional medicine in Northern African communities. The literature is covered for the period 1959–2015 and part III of this review series focuses on plant families with names beginning with letters T to Z. The authors have focused on curating data from journals in natural products and phytomedicine. Within each journal home page, a query search based on country name was conducted. All articles “hits” were then verified, one at a time, that the species was harvested within the Northern African geographical regions. The current data partly constitutes the bases for the development of the Northern African natural compounds database. The review discusses 284 plant-based natural compounds from 34 species and 11 families. It was observed that the ethnobotanical uses of less than 40 % of the plant species surveyed correlated with the bioactivities of compounds identified.Graphical AbstractElectronic supplementary materialThe online version of this article (doi:10.1007/s13659-016-0091-9) contains supplementary material, which is available to authorized users.

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Studies on the Mode of Action of Psoralen Derivatives

Cited by 16 publications

References 17 publications

The Treatment of Vitiligo With a Combination of Psoralens and Quinolines.

The Treatment of Vitiligo With a Combination of Psoralens and Quinolines.

Furocoumarins in Medicinal Chemistry. Synthesis, Natural Occurrence and Biological Activity

The Chemistry and Biological Activities of Natural Products from Northern African Plant Families: From Taccaceae to Zygophyllaceae

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