Studies on the Molecular Organization of the Lens

Farnsworth, Patricia N.; Schleich, Thomas; Groth-Vasselli, Barbara; Kuckel, Charles Lee

doi:10.1159/000266566

Cited by 5 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the number of enzymes known to have spare-time jobs has increased dramatically in recent years. Table 1 shows a few such enzymes (see [1][2][3][4][5][6][7][8][9][10][11][12][13]), chosen to illustrate the diversity of alternative functions. Much more space would be required for a comprehensive list.…”

Section: Introductionmentioning

confidence: 99%

It can be a complicated life being an enzyme

Tipton

O’Sullivan

Davey

et al. 2003

Biochemical Society Transactions

View full text Add to dashboard Cite

It is becoming increasingly apparent that many well-known enzymes have alternative non-enzymic functions. Similarly, several proteins that were identified as having non-catalytic functions were subsequently found to have enzyme activities. Some examples are considered to illustrate the diversity of alternative functions. The semicarbazide-sensitive amine oxidase (EC 1.4.3.6) is considered in more depth as an example. It was originally believed to be a detoxifying enzyme, but the reaction products may have important signalling functions. Furthermore, this enzyme, from some sources, also behaves as a vascular-adhesion protein. Finally, the challenges posed by such multiplicity of functions for the interpretation of genetic deletion, in vivo inhibition and the development of functional protein databases are briefly considered.

show abstract