Studies on the nutritional basis of abnormal behavior in albino rats. V. The effect of pyridoxine deficiency upon sound-induced magnesium tetany.

Ra, Patton; He, Longenecker

doi:10.1037/h0054417

Cited by 11 publications

(21 citation statements)

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“…The induced and "spontaneous" convulsions observed during the foregoing experiments were similar to those previously described in young rats (5,8,12). Systematic tests revealed a continuum of sensitivity in the magnesium deficient rats with seizure patterns of increasing severity correlated with the advancing stages of deficiency.…”

Section: Discussionsupporting

confidence: 83%

Sound-induced convulsions in the hamster associated with magnesium deficiency.

Ra¹

1947

Journal of Comparative and Physiological Psychology

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A recent study (12) described severe sound-induced seizures consisting of hyperactivity and tonic-clonic convulsions which were shown by all of a group of normal young rats maintained on purified diets deficient in magnesium. "Spontaneous" seizures were observed during the terminal stages of deficiency in the absence of demonstrable auditory stimulation. The foregoing study was undertaken in the attempt to relate previous studies of magnesium tetany (5, 6, 8, 10) to the studies of sound-induced seizures in rats described by a number of workers (4).From a comparative point of view it was thought of value to check these findings with another laboratory animal not previously utilized for the study of magnesium deficiency. The golden hamster (Mesocricetus auratus) was selected as a suitable animal. The hamster has become more and more widely utilized for experimental studies in this country. This animal has a number of characteristics which have suggested its suitability as a laboratory animal. The average weight of mature animals rarely exceeds 125-135 grams and its period of rapid growth is relatively short. Likewise the gestation period (about 16 days) is shorter than that of the rat. Hamsters have been found useful in the study of virus diseases as well as for nutritional studies. A good deal of information is now available concerning the care, breeding, and growth of this animal and its nutritional requirements (1,2,9,13). We have found it to be a valuable addition to the laboratory for use in comparative studies of behavior. EXPERIMENTAL Forty-eight male hamsters were utilized in these experiments. When procured the animals were 28 days of age and averaged 35 grams in weight. They were assigned to different experimental groups and housed individually in cages with raised screen bottoms.The components of the basal purified diets (in gms. per 100 gms.) were: sucrose 69; casein (Labco vitamin-free) 18; salt mixture (7) 4; fat (Crisco) 5; Cod liver oil (Mead's) 2; fortified corn oil ( 14) 2. To each 100 grams of diet vitamins in the amounts indicated below were added: 2 1 Part of the data given in this paper was presented at the meeting of the Southern Society for Philosophy and Psychology, April, 1946. 2 The vitamins used in these experiments were provided through the courtesy of Merck and Co., Rahway, New Jersey.

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Section: Discussionsupporting

confidence: 83%

Sound-induced convulsions in the hamster associated with magnesium deficiency.

Ra¹

1947

Journal of Comparative and Physiological Psychology

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“…rigidly to the sides, while the hind limbs were in extension. Such rigidity seemed similar to that shown by a decerebrate preparation (13). During the tonic phase the pupils were dilated and unresponsive to light.…”

Section: Fig 2 Stages Of Electrically Induced Convulsive Seizuressupporting

confidence: 79%

Duration of decrements in learning and retention following electroshock convulsions in the white rat.

Braun¹,

Russell²,

Patton³

1949

Journal of Comparative and Physiological Psychology

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“…The seizures were either a running attack or a clonic type usually preceded by a running attack. No severe tonic convulsions, such as those that often occur in magnesium deficient rats (7,10) were observed in the B 6 -deficient rats.…”

Section: Experimental Procedubesmentioning

confidence: 85%

“…It has been shown that a long time is required to obtain convulsions in rats fed a diet deficient in B 8 from weaning (2,3,7). Group II shows that even when the mother is fed a deficient diet starting not later than the twelfth day after parturition, the young show only a low and sporadic incidence of seizures.…”

Section: Resultsmentioning

confidence: 99%

“…It seemed desirable, therefore, to attempt to obtain repeated seizures in rats deficient in pyridoxin but free of otitis media, and if successful to attempt to reverse the sensitivity by administration of vitamin B 6 . It was apparent from the previous studies that a pyridoxin deficiency induced after weaning would probably lead to only a low incidence of seizures occurring sporadically (2, 3) even with systematic sound tests (7). Furthermore, we wished to carry out tests on rats, at least part of which had exhibited spontaneous convulsions during the nursing period in order to compare the results with the earlier study (5).…”

Section: Purposementioning

confidence: 97%

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