Studies on the Optimal Dosage of Estrogens

The Effect of the Administration of Testosterone Propionate on the Urinary Excretion of Compounds Allied to the Steroid Hormones

“…In case 6, receiving at one period 0-05 mg. of oestradiol benzoate on alternate days, it appears that only a small proportion of the activity of administered oestradiol is recoverable in the urine. This is in accordance with the results of other investigators [Mazer and Israel, 1937 ;Kemp and Pedersen-Bjergaard, 1937], though no work can be said to have been done on human subjects with thoroughly efficient methods of extraction.…”

STUDIES CONCERNING THE MECHANISM CONTROLLING THE INITIATION OF LACTATION AT PARTURITION I. CAN ESTROGEN SUPPRESS THE LACTOGENIC HORMONE OF THE PITUITARY?1,2

“…Several investigators (23,37) have shown that when large amounts of estrogen are administered to lactating rats, a considerable amount of this hormone may be excreted in the milk. In view of the deleterious effects of estrogens on growth (38)(39)(40)(41)(42)(43)(44) this factor alone could account for the decreased growth rate and death of the young. It is also possible that large dosages of estrogen may have injurious effects on the lactating mothers as well, and this seems likely from the finding that there is a decrease in weight of lactating mother-rats following estrogen treatment (19).…”