Studies on the Pathogenesis of Subacute Thyroiditis

Abstract

HLA typing for A, B and C loci (class I antigens) was performed on 89 patients with SAT (males: 7, females: 82) aged from 23 to 66 years, and DR and MT loci (class II antigens) were investigated in 55 patients. In 12 patients, viral antibody titers were measured as soon as possible after onset and two weeks later. The viral antibodies evaluated were those of Influenza A and B, Coxsackie A9, B1, B2, B3, B4, B5 and B6, Echo 3, 7, 11 and 12, Parainfluenza 1, 2, 3 and 4, and Adeno 8 virus. The following results were obtained: In class I HLA typing, the frequency of HLA-Bw35 in SAT was 67.4%, which was significantly (p less than 0.0001) higher than that in the control (14.1%). On the other hand, the frequency of Cw1 in SAT (14.6%) was significantly (p less than 0.01) lower than that of the control (32.1%), and that of Cw3 (65.2%) was significantly (p less than 0.01) higher than that of the control (46.5%). In class II HLA typing, the frequency of DRw8 in SAT was 38.2%, which was significantly (p less than 0.05) higher than that of the control (21.9%). Other antigens showed no significant changes.(ABSTRACT TRUNCATED AT 250 WORDS)

Subacute Thyroiditis is Associated with HLA-B*18:01, -DRB1*01 and -C*04:01—The Significance of the New Molecular Background

“…All of the previously published reports have demonstrated correlations either by comparison with much smaller control groups than ours, or only in individual cases with no data against which to compare [11][12][13][14][15][16][17][18][19]. The frequency of HLA-B*35 in SAT patients varied from 67 to 72.5% [12,20,21]. We compared our 60 SAT patients with 1023 healthy subjects, demonstrating an even stronger association, with the frequency exceeding 81% in SAT subjects as compared to being only 10.2% in the control group.…”

“…The presence of HLA-B35 has been observed in about 70% of SAT patients [12,20,21], but the other possible associations suggested so far have not been definitively confirmed. However, it seems doubtful that in HLA-B35-negative patients, SAT would occur in the absence of any genetic susceptibility.…”

“…Using the serological method, Ohsako et al [20] demonstrated an increased occurrence of HLA-Bw67 and HLA-Cw3 in 56 Japanese patients with SAT, compared to in 238 healthy people. Unfortunately, no other authors have confirmed the association of SAT with HLA-B*67 (current nomenclature) and the potential correlation with HLA-Cw3 has been described again only once-also in a Japanese population [21]. A few authors have also suggested a possible correlation between SAT and HLA-Cw4 [15].…”

Recurrence of Subacute Thyroiditis Over 10 Years after the First Attack in Three Cases.

“…A definite association between the occurrence of this disease and the presence of HLA-BW 3 5 has been demonstrated in European Caucasoids (Nyulassy et al, 1977), Chinese (Yeo et al, 1981), and Japanese patients (Kobayashi et al, 1985). In Japanese patients, the frequency of CW3 and DRW8 was also significantly higher than in the control but no increase in the frequency of A26 in subacute thyroiditis compared with normal subjects was reported (Kobayashi et al, 1985). In the present study, B35, C3 and A26 were positive in all 3 patients.…”

Seroreactivity to A‐type retrovirus proteins in a subset of cats with hyperthyroidism

“…On the basis of these observations, we suggested that a retrovirus may be involved as an etiologic agent in Graves' disease. It is noteworthy that a strong clinical and pathologic association between Sjögren's syndrome and chronic autoimmune thyroiditis has been made in Japanese patients (Kobayashi et al, 1985).…”