Studies on the phospholipase A of dermatophytes

Chopra, Arvind; Larroya, Saroj; Khuller, G. K.

doi:10.1007/bf01642393

Cited by 5 publications

(2 citation statements)

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“…Lysophospholipase helps in the removal of cytotoxic lysophospholipids produced by the action of an intracellular or extracellular phospholipase A in these dermatophytes (31). In addition to these enzymes, phos~)holipase C and glycerophosphocholine diesterase activity was also detected in.these fungi (30,31). Detection of intracellular lipase in Epidermophyton floccosum (32) showed that this enzyme participates in cellular lipid metabolism of the fungus besides assisting in possible invasion of host tissues as described earlier (32)(33)(34).…”

Section: Catabolism Of Lipidsmentioning

confidence: 76%

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Dermatophyte lipids—Composition and regulation of phospholipids

Khuller

Sharma

Deo

2000

Indian J Clin Biochem

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This review presents the extensive work carried out on lipid components of dermatophytes, their biosynthesis, turnover and regulation. It emerges from the work done so far that the pathways of lipid biosynthesis/degradation and the lipid composition in dermatophytes are similar to those in yeasts and other fungi. Second messengers (Ca 2 § cAMP) were demonstrated to have a regulatory role in phospholipid metabolism and they mainly act by stimulating Ca2*/CaM or cAMP dependent protein kinase(s). Both these kinases were purified and characterized in Microsporum gypseum. Further work is being carried out to elucidate the molecular mechanism of regulation of phospholipid metabolism by these second messengers.

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Section: Catabolism Of Lipidsmentioning

confidence: 76%

“…Phospholipase A has been detected in Tfichophyton rubrum, Epidermophyton floccosum, Microsporum cookeL and Tdchophyton mentagrophytes (23,30,31 ). cookei), or both A and A2 type (Trichophyton mentagrophytes) (3b).…”

Section: Catabolism Of Lipidsmentioning

confidence: 99%