Studies on the Repopulation of Langerhans Cells in Partial-Thickness Wounds

Helfman, Todd; Streilein, J. Wayne; Eaglstein, William H.; Mertz, Patricia M.

doi:10.1001/archderm.1993.01680260062007

Cited by 5 publications

(1 citation statement)

References 13 publications

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“…LCs begin to repopulate the neo-epidermis during the remodeling phase of healing [51,372], and a study in humans showed that patients who exhibit efficient healing contained higher densities of LCs in the skin [394]. The source of de novo LCs in healing tissue can be either the local pre-existing LC population in unwounded tissue or from blood-circulating monocytes [395]. In mice, stressed keratinocytes upregulate ligands for lymphocyte activation receptor natural killer group 2D (NKG2D), such as Rae-1, which leads to the migration of LCs from the epidermis [51,396].…”

Section: Skin Immune Responses In Wound Healingmentioning

confidence: 99%

The Dynamics of the Skin’s Immune System

Nguyen

Soulika

2019

IJMS

465

339

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The skin is a complex organ that has devised numerous strategies, such as physical, chemical, and microbiological barriers, to protect the host from external insults. In addition, the skin contains an intricate network of immune cells resident to the tissue, crucial for host defense as well as tissue homeostasis. In the event of an insult, the skin-resident immune cells are crucial not only for prevention of infection but also for tissue reconstruction. Deregulation of immune responses often leads to impaired healing and poor tissue restoration and function. In this review, we will discuss the defensive components of the skin and focus on the function of skin-resident immune cells in homeostasis and their role in wound healing.

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Section: Skin Immune Responses In Wound Healingmentioning

confidence: 99%

The Dynamics of the Skin’s Immune System

Nguyen

Soulika

2019

IJMS

465

339

View full text Add to dashboard Cite

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Increased number of Langerhans cells in the epidermis of diabetic foot ulcers correlates with healing outcome

et al. 2013

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Langerhans cells (LCs) are a specialized subset of epidermal dendritic cells. They represent one of the first cells of immunological barrier and play an important role during the inflammatory phase of acute wound healing. Despite considerable progress in our understanding of the immunopathology of diabetes mellitus and its associated co-morbidities such as diabetic foot ulcers (DFUs), considerable gaps in our knowledge exist. In this study, we utilized the human ex vivo wound model and confirmed the increased epidermal LCs at wound edges during early phases of wound healing. Next, we aimed to determine differences in quantity of LCs between normal human and diabetic foot skin and to learn if the presence of LCs correlates with the healing outcome in DFUs. We utilized immunofluorescence to detect CD207+ LCs in specimens from normal and diabetic foot skin and DFU wound edges. Specimens from DFUs were collected at the initial visit and 4 weeks at the time when the healing outcome was determined. DFUs that decreased in size by >50% were considered to be healing, while DFUs with a size reduction of <50% were considered non-healing. Quantitative assessment of LCs showed a higher number of LCs in healing when compared to non–healing DFU’s. Our findings provide evidence that LCs are present in higher number in diabetic feet than normal foot skin. Healing DFUs show a higher number of LCs compared to non-healing DFUs. These findings indicate that the epidermal immune barrier plays an important role in the DFU healing outcome and may offer new therapeutic avenues targeting LC in non-healing DFUs.

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Daily rhythms of urotensin I and II gene expression and hormone secretion in the caudal neurosecretory system of the euryhaline flounder (Platichthys flesus)

Zhang

Xiong

et al. 2013

General and Comparative Endocrinology

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Studies on the Repopulation of Langerhans Cells in Partial-Thickness Wounds

Cited by 5 publications

References 13 publications

The Dynamics of the Skin’s Immune System

The Dynamics of the Skin’s Immune System

Increased number of Langerhans cells in the epidermis of diabetic foot ulcers correlates with healing outcome

Daily rhythms of urotensin I and II gene expression and hormone secretion in the caudal neurosecretory system of the euryhaline flounder (Platichthys flesus)

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