Studies on the role of non-coding RNAs in controlling the activity of T cells in asthma

Sufianov, Albert; Bessonova, Marina; Begliarzade, Sema; Kudriashov, Valentin; Danilov, A.I.; Ilyasova, Tatiana; Wang, Yaolou; Nafikova, R A; Beylerli, Ozal

doi:10.1016/j.ncrna.2023.02.004

Cited by 6 publications

(2 citation statements)

References 99 publications

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“…55 The miRNAs are associated with many downstream effects that regulate a variety of biological processes. [56][57][58] The miRNAs have significant roles in proper renal function and have significant impacts on mesangial cells, podocytes, and tubular epithelial cells. The miRNA-192 produces tubular interstitial fibrosis and glomerular mesangial cell fibrosis through many mechanisms.…”

Section: Drug Delivery Strategies For Renal Antifibrosismentioning

confidence: 99%

Advances in drug delivery-based therapeutic strategies for renal fibrosis treatment

Huang,

Lu,

Chen

et al. 2024

J. Mater. Chem. B

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Section: Drug Delivery Strategies For Renal Antifibrosismentioning

confidence: 99%

Advances in drug delivery-based therapeutic strategies for renal fibrosis treatment

Huang,

Lu,

Chen

et al. 2024

J. Mater. Chem. B

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“…Bronchial asthma is common in clinical practice and is often referred to as asthma [1]. Airway hyperresponsiveness, airway remodeling, and reversible respiratory restriction are the main pathological features of asthma [2].…”

Section: Introductionmentioning

confidence: 99%

SFRP5 Partially Inhibits the Proliferation and Migration of Airway Smooth Muscle Cells in Children with Asthma by Regulating the Wnt/β-Catenin Signaling Pathway

Yuan,

Zhu,

Huang

et al. 2024

Discovery Medicine

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Background: Childhood asthma is a chronic inflammatory disease of the respiratory tract characterized by bronchial inflammation, airway hyperresponsiveness, airflow disorder, and obstruction. Secreted frizzled-related protein 5 (SFRP5) may be associated with respiratory inflammatory diseases. This study investigated the effect of SFRP5 on human airway smooth muscle cells (HASMCs) to provide new ideas for treating asthma. Methods: A total of 30 children with asthma and 30 children who had a physical examination at the same time were selected and divided into asthma and healthy groups. Serum SFRP5 levels were determined by enzyme-linked immunosorbent assay (ELISA) and real-time quantitative polymerase chain reaction (RT-qPCR). Lipofectamine 2000™ regent was used to transfect the SFRP5 overexpression plasmid (pc-SFRP5) or corresponding negative control (pc-NC) into HASMCs. HASMCs were treated with 10 µg/L platelet-derived growth factor-BB (PDGF-BB), which is an inducer to mimic the asthma-like condition at the cellular level of childhood asthma. HASMCs were divided into control, PDGF-BB (PDGF-BB treatment), PDGF-BB+pc-NC (pc-NC transfection and PDGF-BB treatment), and PDGF-BB+pc-SFRP5 (pc-SFRP5 transfection and PDGF-BB treatment) groups. Cell proliferation was measured by 5-ethynyl-2 ′ -deoxyuridine (EdU) and cell counting kit-8 (CCK-8) assay. Cell migration was detected by Transwell assay. The protein expression was detected by western blot. Results: Serum SFRP5 expression in the asthmatic group was decreased versus the healthy group (p < 0.0001). Induction of PDGF-BB decreased SFRP5 expression in HASMCs (p < 0.01). SFRP5 expression in the pc-SFRP5 group was increased (p < 0.01). The proliferation and migration of HASMCs increased after PDGF-BB treatment (p < 0.001, p < 0.0001), indicating that the asthma model was successfully inducted in vitro. Moreover, the expression of β-catenin, cellular-myelocytomatosis viral oncogene (c-Myc), and cyclinD1 proteins in HASMCs increased after PDGF-BB treatment (p < 0.0001). SFRP5 overexpression partly inhibited PDGF-BB-induced proliferation, migration, and expressions of β-catenin, c-Myc, and cyclinD proteins in HASMCs (p < 0.01, p < 0.001, p < 0.0001). Conclusions: Serum SFRP5 expression decreases in children with asthma. SFRP5 overexpression partially inhibits PDGF-BBinduced HASMC proliferation and migration by regulating the wingless-type mouse mammary tumor virus (MMTV) integration site family (Wnt)/β-catenin pathway.

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Non-coding RNA regulation of macrophage function in asthma

Tian,

Gao,

Yang

et al. 2023

Cellular Signalling

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Studies on the role of non-coding RNAs in controlling the activity of T cells in asthma

Cited by 6 publications

References 99 publications

Advances in drug delivery-based therapeutic strategies for renal fibrosis treatment

Advances in drug delivery-based therapeutic strategies for renal fibrosis treatment

SFRP5 Partially Inhibits the Proliferation and Migration of Airway Smooth Muscle Cells in Children with Asthma by Regulating the Wnt/β-Catenin Signaling Pathway

Non-coding RNA regulation of macrophage function in asthma

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