Studies on the thymus of the mammal. V. On the origin of adipose cells replacing the thymus

Smith, Christianna; E, Samson; Padykula, Helen A.; Laskey, Marie Graham; Loewenthal, Lois A.

doi:10.1002/jmor.1050900106

Cited by 7 publications

(1 citation statement)

References 14 publications

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“…Wassermann states that connective tissue cells may take up fat, especially under pathological conditions; but he believes this is merely an exhibition of phagocytic function. Smith et al (1952) studying the involution of the thymus in the rat concluded that the fat cells within the thymus develop from primitive reticular cells, lymphocytes, and macrophages. Tedeschi (1946) reported non-encapsulated fat tissue growths in scattered and disorderly fashion both in subcutaneous tissue and internal cavities of the body but noted that the growth was similar to that by which fat tissue develops in either embryonal or adult life under normal conditions.…”

Section: Discussionmentioning

confidence: 99%

The Organ-Like Nature of the Subcutaneous Fat Bodies in the Chicken ,

Liebelt

Eastlick

1954

Poultry Science

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Section: Discussionmentioning

confidence: 99%

The Organ-Like Nature of the Subcutaneous Fat Bodies in the Chicken ,

Liebelt

Eastlick

1954

Poultry Science

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Postnatal development on two types of fat depots in the NH and CBA inbred strains of mice

Liebelt

1959

Am. J. Anat.

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The stroma of the thymus of the rat: Morphology and antigen diffusion, a reconsideration

1986

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This work reconsiders aspects of the morphology of the capsule, of the blood vasculature, of the distribution of reticular fibers, and of the diffusion of intramediastinally injected antigens in the stroma of the thymus of the rat. This was done by an analysis of standard sections of normal thymuses, of sections of thymuses perfused with colloidal carbon, of silver-impregnated sections, and of sections of thymuses of rats injected intramediastinally with a fluorescent antigen or intravenously with Trypan blue, and by electron microscopy of the thymic capsule. The capsule consisted of two layers: an outer layer covering the entire periphery of a thymic lobe, and an inner layer which outlined the entire convoluted peripheral cortex of a lobe. Cortical vessels entered the capsule and septa in which they formed a capillary network. These capsular capillaries were fenestrated and leukocytes were often present near them. Adipocytes were also seen near these vessels in some areas of the capsule, and often at the bases of septa and trabeculae. Furthermore, much of the medulla had a dense network of coarse reticular fibers, whereas the remainder of the medulla and the cortex contained a loose network of fine fibers stretching out from the capsule, septa, and trabeculae. Intramediastinally injected fluorescent antigens were observed to spread in the capsule and septa and to diffuse in the fiber networks stretched across the cortex and the medulla. Fluorescence also highlighted cortical reticular cells but not the thymocytes. Intravenously injected Trypan blue stained the capsule, the septa, the cortical reticular cells, and the autofluorescent cells outlining the corticomedullary junction of each lobule. The unusual penetration of capillaries from the thymic parenchyma into the thymic capsule suggested that the capsular capillaries participate in peculiar thymic events, such as the recruitment of blood stem-cells. It is concluded that small amounts of blood antigens normally exude from capsular capillaries and diffuse into the fibers extending from the capsule across the cortex. The phenomenon would be increased under conditions causing thymic involution. An explanation is proposed to account for the development of involution which involves the exudation of antigens from the capsular capillaries. A comparable mechanism could also account for the development of a particular experimental immune tolerance.

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Studies on the thymus of the mammal. V. On the origin of adipose cells replacing the thymus

Cited by 7 publications

References 14 publications

The Organ-Like Nature of the Subcutaneous Fat Bodies in the Chicken ,

The Organ-Like Nature of the Subcutaneous Fat Bodies in the Chicken ,

Postnatal development on two types of fat depots in the NH and CBA inbred strains of mice

The stroma of the thymus of the rat: Morphology and antigen diffusion, a reconsideration

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