Studies on zinc bioavailability from a representative diet in Chinese urban women of childbearing age using a double label stable isotope technique

Yang, Lichen; Yang, Xiaoguang; Piao, Jianhua; Tian, Yuan; Li, Peng-Gao; Wang, Yan; Wang, Jun

doi:10.1016/j.jtemb.2005.09.001

Cited by 10 publications

(7 citation statements)

References 11 publications

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“…Since the IZiNCG algorithm was published, six new data points from three studies of zinc absorption in adults meeting the IZiNCG criteria above have been identified [34][35][36]. Three of the diets studied had a phytate:zinc molar ratio greater than 18 and three of 18 or less.…”

Section: S437mentioning

confidence: 99%

Dietary Indicators for Assessing the Adequacy of Population Zinc Intakes

Hotz¹

2007

Food Nutr Bull

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Section: S437mentioning

confidence: 99%

Dietary Indicators for Assessing the Adequacy of Population Zinc Intakes

Hotz¹

2007

Food Nutr Bull

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“…Natural Zn consists of five stable isotopes, and the natural abundance of 67 Zn (4.1%), 68 Zn (18.8%) and 70 Zn (0.6%) are sufficiently low for their utilization as tracers (Krebs & Hambidge 2001). Many researchers orally administered stable isotopic Zn as a tracer and the TA of Zn was determined as the absorption of the tracer, and the EFL of Zn was calculated from the difference between the TA and the apparent absorption of Zn in rats (Rubio et al 1994;Takasugi et al 2007), pigs (Chu et al 2009) and humans (Rauscher & Fairweather-Tait 1997;Yang et al 2005). However, to our knowledge, the TA and EFL of Zn have not been studied using stable isotopic Zn in ruminants.…”

Section: Introductionmentioning

confidence: 99%

Determination of true absorption and fecal endogenous loss of zinc in goats

Hattori¹,

Torii²,

Funaba³

et al. 2010

Animal Science Journal

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We determined the true absorption and endogenous fecal loss of zinc (Zn) in goats using its stable isotope. Three goats were fed with the diet containing 50 mg/kg Zn twice a day for 17 days. In the morning of day 11, the goats were given a meal labeled by (67) Zn as the tracer with dysprosium as the unabsorbed marker. Then the goats were given unlabeled diet as the rest of the morning feed. We measured dietary and fecal Zn concentration, (67) Zn abundance and dysprosium concentration in feces. The excretion pattern of the tracer Zn into feces differed from that of dysprosium. Therefore, we directly calculated the true absorption of Zn from Zn concentration and (67) Zn abundance in fecal samples collected after the labeled diet was given. The apparent absorption of Zn was -0.009 ± 0.016 mg/kg bodyweight (fractional absorption, -1.07 ± 1.85%). The true absorption of Zn was 0.162 ± 0.018 mg/kg bodyweight (fractional absorption, 18.25 ± 2.01%). The endogenous fecal loss of Zn was 0.172 ± 0.004 mg/kg bodyweight and the intestinal secretion of Zn was 0.210 ± 0.009 mg/kg bodyweight. The present experiment indicates that stable isotopic Zn is a powerful tool for examining Zn metabolism in ruminants.

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“…It is recommended as the method of choice for determination of fractional zinc absorption (12, 13, 15, 19). The technique applied to a spot urine specimen is easy to implement and not sensitive to participant compliance.…”

Section: Discussionmentioning

confidence: 99%

“…The goal of the present trial was to use the double-isotope tracer ratio (DITR) 7 method (11–13) to compare zinc absorption from zinc citrate with zinc gluconate and zinc oxide when these zinc compounds were given as supplements without food. This is recommended to maximize zinc absorption and is usually advised for diarrhea treatment.…”

Section: Introductionmentioning

confidence: 99%

Zinc Absorption by Young Adults from Supplemental Zinc Citrate Is Comparable with That from Zinc Gluconate and Higher than from Zinc Oxide

Wegmüller

Tay²,

Zeder

et al. 2014

The Journal of Nutrition

116

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The water-soluble zinc salts gluconate, sulfate, and acetate are commonly used as supplements in tablet or syrup form to prevent zinc deficiency and to treat diarrhea in children in combination with oral rehydration. Zinc citrate is an alternative compound with high zinc content, slightly soluble in water, which has better sensory properties in syrups but no absorption data in humans. We used the double-isotope tracer method with 67Zn and 70Zn to measure zinc absorption from zinc citrate given as supplements containing 10 mg of zinc to 15 healthy adults without food and compared absorption with that from zinc gluconate and zinc oxide (insoluble in water) using a randomized, double-masked, 3-way crossover design. Median (IQR) fractional absorption of zinc from zinc citrate was 61.3% (56.6–71.0) and was not different from that from zinc gluconate with 60.9% (50.6–71.7). Absorption from zinc oxide at 49.9% (40.9–57.7) was significantly lower than from both other supplements (P < 0.01). Three participants had little or no absorption from zinc oxide. We conclude that zinc citrate, given as a supplement without food, is as well absorbed by healthy adults as zinc gluconate and may thus be a useful alternative for preventing zinc deficiency and treating diarrhea. The more insoluble zinc oxide is less well absorbed when given as a supplement without food and may be minimally absorbed by some individuals. This trial was registered at clinicaltrials.gov as NCT01576627.

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Studies on zinc bioavailability from a representative diet in Chinese urban women of childbearing age using a double label stable isotope technique

Cited by 10 publications

References 11 publications

Dietary Indicators for Assessing the Adequacy of Population Zinc Intakes

Dietary Indicators for Assessing the Adequacy of Population Zinc Intakes

Determination of true absorption and fecal endogenous loss of zinc in goats

Zinc Absorption by Young Adults from Supplemental Zinc Citrate Is Comparable with That from Zinc Gluconate and Higher than from Zinc Oxide

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