Studies Upon the Mechanism of Reserpine-Induced Arrest in Egg Transport in the Mouse Oviduct

Abstract

The position of eggs in the reproductive tract of the mouse was determined following the administration of several drugs with effects on smooth muscle and tissue amines. Of the compounds examined, only chlorpromazine and tetrabenazine were effective in causing a reduction in the rate of egg transport in the oviduct. Both compounds, like reserpine, caused hypothermia in the mouse. Further investigation showed that the arrest of egg transport can be prevented by housing animals at elevated environmental temperatures. The implications of these findings in relation to the physiology of the mouse oviduct are discussed.

Effects of Sympathetic Denervation of the Rabbit Oviduct on Normal Ovum Transport and on Transport Modified by Estrogen and Progesterone

“…Reserpine acts centrally to induce hypothermia and to interfere with gonadotropin secretion. It acts system atically to lower blood pressure, it may alter regional blood flow by de pressing myocardial function, and it may directly, but nonspecifically de press the activity of the oviduct [1,9,15,16,27].…”

Method for maintaining embryo transport in mouse oviducts in vitro

“…The position of embryos in the reproductive tract and the mean percentage oviduct traversed were determined by the method of Kendle & Bennett (1969).…”

The effect of reserpine, oestradiol and in-vitro perfusion on oviduct calcium levels in the mouse during egg transport

“…The position of the eggs in the oviduct and the mean percentage oviduct traversed by the eggs were determined by the methods of Bennett & Kendle (1967) and Kendle & Bennett (1969).…”