Studies with a Uterine Antispasmodic, Ambucetamide**Research Division, Bristol Laboratories Inc., Syracuse, N. Y.

Hoekstra, Justin B.; Fisher, Dorothea S.; Cull, K.M.; Tisch, D. E.; Dickison, H. L.

doi:10.1002/jps.3030460915

Cited by 3 publications

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“…Ambucetamide [a-dibutylamino-a-(p-methoxyphenyl)acetamide; Dibutamide] is an antispasmodic drug which has been found to have some use in alleviating dysmenorrhoea (Carpenter and Janssen, 1955 ;Hoekstra, Fisher, Cull, Tisch, and Dickison, 1957). The " menstrual stimulant" is a plain-muscle stimulant of endometrial origin, overactivity of which is considered to be a possible cause of dysmenorrhoea (Chambers and Pickles, 1958;Pickles, 1959).…”

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The Effects of Ambucetamide on Human Myometrial and Other Preparations, and Its Antagonism to the Menstrual Stimulant

Pickles

Clitheroe

1960

British Journal of Pharmacology and Chemotherapy

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A plain‐muscle stimulant, provisionally named the “menstrual stimulant,” may be involved in the causation of dysmenorrhoea. Since ambucetamide [α‐dibutylamino‐α‐(p‐methoxyphenyl)‐acetamide] has been claimed to alleviate this condition, its effects on the responses of human myometrial preparations to the menstrual stimulant have been studied. Ambucetamide regularly inhibited these responses, as well as those to vasopressin, and sometimes diminished the spontaneous rhythmical activity of the human myometrium. The rat and guinea‐pig uterus, the guinea‐pig and cat intestine preparations, showed more complex responses and may therefore be less suitable for testing antispasmodic drugs intended for treatment of dysmenorrhoea.

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confidence: 99%