Studies with Emulsion Containing trans-resveratrol: in vitro Release Profile and ex vivo Human Skin Permeation

Almeida, Priscila Aparecida de; Alves, Michele Campos; Polonini, Hudson; Calixto, Stephane Lima; Gomes, Tiago Brum Braga; Lataliza, Alexandre Augusto Barros; Ramos, Cristiano; Raposo, Nádia Rezende Barbosa; Ferreira, Adriana; Brandão, Marcos Antônio Fernandes

doi:10.2174/1567201812666150130161736

Cited by 6 publications

(3 citation statements)

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“…This liposomal vehicle was already found to be suitable for delivering resveratrol transdermally [8,9], because the vesicles are intended to increase the solubility of hydrophobic drugs, improving both release kinetics and bioavailability.…”

Section: Resultsmentioning

confidence: 99%

“…This is why new oral delivery systems, such as micellar solutions, cyclodextrins, solid lipid nanoparticles, liposomes, multiparticulate calcium-pectinate carriers, acoustically active lipospheres, and chitosan microspheres, are currently being studied. Nevertheless, these methods have limited use due to their inefficient systemic delivery [7], which encouraged new strategies such as transdermal delivery [8,9] and transmucosal delivery viathe vaginal route, which is our main focus here, as it has not been studied yet, to the best of the authors' knowledge.…”

Section: Introductionmentioning

confidence: 99%

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Permeation profiles of resveratrol cream delivered through porcine vaginal mucosa: Evaluation of different HPLC stationary phases

Polonini

Soldati

Almeida

et al. 2015

Journal of Chromatography B

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Permeation profiles of resveratrol cream delivered through porcine vaginal mucosa: Evaluation of different HPLC stationary phases

Polonini

Soldati

Almeida

et al. 2015

Journal of Chromatography B

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“…In our continuing investigations on the role of antioxidants in UV-mediated skin disorders [5], we focused our studies on trans-resveratrol (RES) and N-acetylcysteine (NAC), both of which are currently widely used antioxidants [6][7][8][9]. Previously published studies on RES permeation through excised human skin showed that this method of application may be a good alternative to the oral route [10,13]. Few topical applications of NAC have been described [14].…”

mentioning

confidence: 99%

Self-Nanoemulsifying System in the Accumulation of Resveratrol and N- Acetylcysteine in the Epidermis and Dermis

Laneri

Sacchi

Fratter³

et al. 2017

Natural Product Communications

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Trans -resveratrol (RES) and N-acetylcysteine (NAC) have protective effects on biological processes; therefore, they are frequently included in food supplements. Their possible applications for the prevention of free radical-induced damage to the skin are of particular physiological relevance; however, their usefulness is limited by their metabolic fate and the unpredictability of their delivery to the skin following oral administration. In this work, we evaluated the concomitant and direct application of RES and NAC on the skin using a self-nanoemulsifying system we previously developed for the oral delivery of poorly absorbed food supplements. We evaluated the capability of this system to increase RES and NAC accumulation in porcine skin using permeation studies in Franz diffusion cells. The ascorbyl palmitate (ASP) self-nanoemulsifying system considerably increased RES and NAC accumulation in the epidermis and dermis, which peaked 6 h after application. This study reveals a new formulation strategy to improve the bioavailability of ingredients, which was previously used in the health supplements field, but has rarely been employed in dermatology because of its poor distribution in the skin.

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Use of Polyphenolic Compounds in Dermatologic Oncology

2016

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Polyphenols are a widely used class of compounds in dermatology. While phenol itself, the most basic member of the phenol family, is chemically synthesized, most polyphenolic compounds are found in plants and form part of their defense mechanism against decomposition. Polyphenolic compounds, which include phenolic acids, flavonoids, stilbenes, and lignans, play an integral role in preventing the attack on plants by bacteria and fungi, as well as serving as cross-links in plant polymers. There is also mounting evidence that polyphenolic compounds play an important role in human health as well. One of the most important benefits, which puts them in the spotlight of current studies, is their antitumor profile. Some of these polyphenolic compounds have already presented promising results in either in vitro or in vivo studies for non-melanoma skin cancer and melanoma. These compounds act on several biomolecular pathways including cell division cycle arrest, autophagy, and apoptosis. Indeed, such natural compounds may be of potential for both preventive and therapeutic fields of cancer. This review evaluates the existing scientific literature in order to provide support for new research opportunities using polyphenolic compounds in oncodermatology.

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Studies with Emulsion Containing trans-resveratrol: in vitro Release Profile and ex vivo Human Skin Permeation

Cited by 6 publications

References 0 publications

Permeation profiles of resveratrol cream delivered through porcine vaginal mucosa: Evaluation of different HPLC stationary phases

Permeation profiles of resveratrol cream delivered through porcine vaginal mucosa: Evaluation of different HPLC stationary phases

Self-Nanoemulsifying System in the Accumulation of Resveratrol and N- Acetylcysteine in the Epidermis and Dermis

Use of Polyphenolic Compounds in Dermatologic Oncology

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