Study of 9 Cases of Tuberculosis Pneumonia in Children at Chu of Brazzaville, Congo

Nika, E.R.; Babéla, Jean Robert Mabiala; Mandilou, Steve Vassili Missambou; Moyen, G.

doi:10.1177/2333794x16651512

Cited by 5 publications

(6 citation statements)

References 9 publications

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“…[12] Other studies done in Uganda and Congo showed contrary results where they found that TB is more likely to occur in children under two years of age. [6,13] HIV positive children were 24 times more likely to develop PTB compared to their counterparts who were HIV negative. HIV destroys CD4+ cell and T cell mediated immunity which is critical in fighting against TB bacilli.…”

Section: Factors Associated With Ptb In Children Presenting With Seve...mentioning

confidence: 95%

Pulmonary tuberculosis among young children with severe pneumonia at Al Sabah Children’s Hospital, Juba, South Sudan

Madison¹,

Ndeezi²,

Chollong³

et al. 2021

SSMJ

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Background: Tuberculosis is a major public health problem worldwide. It can present in an acute form especially in endemic settings, which might lead to missed and delayed diagnosis, prolonged hospital stays, and increased mortality in children. South Sudan has a high prevalence of tuberculosis in the adult population. However, there is no published data on paediatric tuberculosis. We aimed to determine the prevalence and factors associated with pulmonary tuberculosis in children admitted with pneumonia in Al Sabah Children’s Hospital, South Sudan.Method: This was a cross sectional study of 404 children aged 2 to 59 months admitted with severe pneumonia from June-October 2018 at Al Sabah Children’s Hospital. We excluded children on anti-TB treatment. Data were collected using a pretested questionnaire which captured socio-demographic characteristics, clinical history, physical examination, and laboratory investigations. Sputum examination for Mycobacterium tuberculosis was performed for all participants using X-pert MTB/RIF. Additional investigations included Chest X-ray and blood count.Results: We recruited 404 children, out of which 78 (19.3%) had pulmonary tuberculosis. Of these, 13 (16.7%) were bacteriologically confirmed while 65 (83.3%) were clinically diagnosed. The factors significantly associated with pulmonary tuberculosis were age above two years [AOR 2.32 (95% CI 1.04-5.17)] p value 0.039, positive HIV Status [AOR 24.2 (95% CI 2.88-202.62)] p value 0.003, severe acute malnutrition [AOR 15.67 (95% CI 6.68-36.73)] p value <0.001, lack of BCG immunization [AOR 3.09 (95% CI 1.06-9.03)] p value 0.038, and contact with a known tuberculosis patient [AOR 55.14 (95% CI 10.12-300.6)] p value <0.001.Conclusion: There is a high burden of pulmonary tuberculosis in children presenting with severe pneumonia. There is a need for screening for pulmonary tuberculosis in children with any of the associated factors to improve early diagnosis and treatment.

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Section: Factors Associated With Ptb In Children Presenting With Seve...mentioning

confidence: 95%

Pulmonary tuberculosis among young children with severe pneumonia at Al Sabah Children’s Hospital, Juba, South Sudan

Madison¹,

Ndeezi²,

Chollong³

et al. 2021

SSMJ

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“…Second, Africa accounts for 29% of global tuberculosis cases [15] that cause pneumonia [16]. Even worse, its symptoms are typical of other bacterial pneumonia, which leads to inadequate treatment [17].…”

Section: Open Accessmentioning

confidence: 99%

Current Context of Pneumonia Amidst the COVID-19 Pandemic in Africa

Uwishema

Onyeaka

Alshareif

et al. 2021

J CONT STUDIES EPIDE PUBL HEALTH

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Since the emergence of the coronavirus disease 2019 (COVID-19) pandemic, several countries have been strongly affected by the different impacts of the disease. This has not been different in Africa, where in addition to the current load of COVID-19, there are other epidemics (such as pneumonia) that have aggravated the situation. In this perspective article, we discuss various aspects of pneumonia amidst the COVID-19 pandemic in Africa, including its burden, current status and efforts, and related challenges.

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“…6 Kolonisasi bakteri patogen adalah tanda penurunan fungsi sistem imun yang tidak mampu membersihkan patogen yang terhirup. 9 Kasus ini datang dengan gejala akut Riwayat kontak dengan pasien terdiagnosis TB merupakan kriteria yang sangat penting untuk diagnosis TB. Riwayat kontak dengan orang dewasa terdiagnosis TB paru atau memiliki gambaran klinis TB memperkuat kemungkinan diagnosis TB.…”

Section: Diskusiunclassified

Pemeriksaan Adenosine Deaminase (ADA) sebagai Alternatif Diagnosis TB pada Anak

Tarigan¹,

Iskandar²

2022

CDK

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Pendahuluan. Diagnostik tuberkulosis (TB) pada anak merupakan masalah tersendiri karena manifestasi klinis yang beragam dan tidak tersedianya standar baku penegakan diagnosis. Kasus. Anak perempuan usia 6 tahun, dengan klinis demam, batuk, dan sesak nafas. Pada pemeriksaan fisik didapatkan penurunan suara napas di rongga dada kanan. Hasil pemeriksaan radiologis didukung ultrasonografi tampak gambaran efusi pleura kanan yang sebagian sudah terorganisasi. Hasil uji laboratorium didapatkan leukositosis dan hasil tes IGRA negatif. Analisis cairan pleura menunjukkan peningkatan kadar adenosin deaminase. Pengobatan TB menghasilkan perbaikan klinis dan radiologis bermakna. Simpulan. Pemeriksaan adenosin deaminase dapat dipertimbangkan untuk alternatif diagnosis TB pada anak.Diagnosis of tuberculosis (TB) in children is still problematic because of various clinical manifestations and the unavailability of diagnostic standard. Case. A 6-year old girl with fever, cough and shortness of breath. On physical examination, there was a decrease breath sounds in the right chest. Radiology examination showed a partially organized right pleural effusion, supported with ultrasound finding. Lab test found leucocytosis and IGRA test was negative. Pleural fluid analysis showed increased adenosine deaminase level. TB treatment resulted in significant clinical and radiological improvement. Conclusion. Adenosine deaminase test can be considered as an alternative for TB diagnosis in children.

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Study of 9 Cases of Tuberculosis Pneumonia in Children at Chu of Brazzaville, Congo

Cited by 5 publications

References 9 publications

Pulmonary tuberculosis among young children with severe pneumonia at Al Sabah Children’s Hospital, Juba, South Sudan

Pulmonary tuberculosis among young children with severe pneumonia at Al Sabah Children’s Hospital, Juba, South Sudan

Current Context of Pneumonia Amidst the COVID-19 Pandemic in Africa

Pemeriksaan Adenosine Deaminase (ADA) sebagai Alternatif Diagnosis TB pada Anak

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