Study of adduct compounds between oxovanadium complexes VO(IV) and some biological relevance using FTIR technique

Jassem, Ahmed Majeed; Mohammed, Mohammed Qasim; Alharis, Raed A.; Jabir, Hadi Abdalsamad; Alzearah, Intisar Naser

doi:10.1007/s11696-019-00949-w

Cited by 8 publications

(4 citation statements)

References 56 publications

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“…32 The peaks at 1624 and 1543 cm −1 were attributed to the asymmetric stretch of the carboxylic acid group in the ligand, which stretched symmetrically at 1423 and 1390 cm −1 . 33 The peak at 989 cm −1 was the V�O stretching band, 34 while 885 and 520 cm −1 , respectively, corresponded to the vibration modes of V−O−V and VO 2 . 35 The microscopic morphological characteristics of the VNSs were obtained by atomic force microscopy with a surface roughness of 10.7 nm (Figure S4A).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Double-Enzyme Active Vanadium Nanospheres-Mediated Ratiometric Multicolor Immunosensors for Sensitive Detection of the T-2 Toxin

Cao

et al. 2023

Anal. Chem.

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Owing to its high throughput, simplicity, and rapidity, enzyme-linked immunosorbent assay (ELISA) has attracted much attention in the field of immunoassays. However, the traditional ELISA usually affords a single signal readout and the labeling ability of the enzyme used is poor, resulting in low accuracy and a limited detection range. Herein, a vanadium nanospheres (VNSs)-mediated competitive ratio nanozymes-linked immunosorbent assay (VNSs-RNLISA) was created for the sensitive detection of the T-2 toxin (T-2). As the key to the biosensor, the VNSs with superoxide dismutase-like and peroxidase-like dual-enzyme mimetic activities were synthesized by a one-step hydrothermal method, which oxidized 1,1-diphenyl-2-picryl-hydrazyl fading and catalyzed 3,3′,5,5′-tetramethylbenzidine (TMB) color development. Therefore, T-2 could not only be qualitatively measured with the naked eye but also be quantitatively evaluated by monitoring the ratio of absorbance at 450 and 517 nm wavelengths. Moreover, the characterization of a VNSs-labeled antibody probe showed strong dual-enzymatic activity, excellent stability, and high affinity with T-2 [the affinity constant (k a) was approximately 1.36 × 108 M–1], which can significantly improve the detection sensitivity. The limit of detection of VNSs-RNLISA was 0.021 ng/mL, which was approximately 27-fold more sensitive than the single signal nanozymes-linked immunosorbent assay (0.561 ng/mL). Besides, the change in the ratio of absorbance (Δ450/Δ517) decreased linearly in a range of 0.22–13.17 ng/mL, outperforming the detection range of a single-mode nano-enzyme-linked immunosorbent assay using TMB by a factor of 1.6 times. Furthermore, the VNSs-RNLISA was successfully used to identify T-2 in maize and oat samples, with recoveries ranging from 84.216 to 125.371%. Overall, this tactic offered a promising platform for the quick detection of T-2 in food and might broaden the application range of the enzyme-linked immunosorbent assay.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Double-Enzyme Active Vanadium Nanospheres-Mediated Ratiometric Multicolor Immunosensors for Sensitive Detection of the T-2 Toxin

Cao

et al. 2023

Anal. Chem.

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“…The compounds are amorphous powder solids and every one shows few peaks indicating their amorphous natures. [13,41,42]…”

Section: X-ray Diffractionmentioning

confidence: 99%

The double‐edged sword of the amoxicillin antibiotic against prostate cancer in nano palladium form and its electrochemical detection of dopamine

Hassan

Hanna

Medany

2023

Applied Organom Chemis

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Pd (II) complex was prepared from the interaction with Schiff base based on the condensation amoxicillin trihydrate drug and 4-N,N-dimethylaminobenzaldehyde. The complex was prepared on the nanoscale that was investigated using transmission electron microscopy (TEM). The chemical structure of the synthesized Schiff base and its Pd (II) chelate was proved through several techniques. Assays using MTT and lactate dehydrogenase verified the Pd (II) complex ability to inhibit human prostate cancer cells (PC3). According to the findings, the inhibition of PC3 cell growth was directly proportional to the dose of Pd (II) complex. Its highest IC 50 value was attained after 48 h of incubation reached to 22.6 μg/mL. As a measure of DNA damage in PC3 cells, this IC50 value demonstrated a significant increase in early and late apoptotic cells with an intense comet nucleus. Given that the concentration of reactive oxygen species (ROS) in treated PC3 cells was much higher than in control ones. These results contributed to the notion that ROS-mediated cell death, which may have taken place via the mitochondrial pathway, was the mechanism by which the Pd (II) complex inhibited the proliferation of PC3 cancer cells. The prepared Pd (II) complex was fabricated and casted onto GC electrode for investigate the dopamine concentration in human serum. The limit of detection and limit of quantization were found to be 0.0127 and 0.0424 μM, respectively, which were in a good agreement with literature and were found to be an improvement to that present in the literature.

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“…The Pd-NBM and VO-NBM complexes are powder solids (amorphous), and each one shows only a peak at 2θ = 20-30 , indicating their amorphous natures. [44] The major refluxes were measured and corresponding dvalues were obtained as represented in Table 5. The average crystallite size (d XRD ) of the complexes was calculated F I G U R E 3 Mass spectral charts using Scherer's formula [42] ; the particle size is given by t = 0.9 λ/Bcosθ, where B is half-width (in radians), t is the crystal thickness (in nm), λ is the wavelength, and θ is the Bragg angle.…”

Section: Diabetic Untreated Controlmentioning

confidence: 99%

The dual therapeutic effect of metformin nuclei‐based drugs modified with one of Tulbaghia violacea extract compounds

Hassan

Bedir

Hamza

et al. 2022

Applied Organom Chemis

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Novel Schiff base was synthesized from condensation reaction of metformin with [4-(Diethylamino) benzaldehyde (NBM). Different metal complexes were prepared using Pd(II), Pt(II), Cu(II) and V(IV) metal ions. All complexes showed the non-electrolytic behavior. So, the expectedThe cytotoxicity of (NBM) Schiff base and its metal complexes on human cancer cell line, MCF-7, was investigated. V(IV) and Cu (II) complexes showed potential blood-glucose lowering effect higher than the commercial metformin drug. VO(IV) complex has superior antioxidant activity more than the other synthesized compounds and the standard ascorbic acid. Molecular docking investigation proved the presence of interesting interactions between all synthesized compounds with the active site amino acids of EGFR tyrosine kinase (anticancer activity). The molecular docking of metal complexes observed effective inhibition for the specific mTOR protein that is expected to aid the growth of the COVID-19 virus.

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Study of adduct compounds between oxovanadium complexes VO(IV) and some biological relevance using FTIR technique

Cited by 8 publications

References 56 publications

Double-Enzyme Active Vanadium Nanospheres-Mediated Ratiometric Multicolor Immunosensors for Sensitive Detection of the T-2 Toxin

Double-Enzyme Active Vanadium Nanospheres-Mediated Ratiometric Multicolor Immunosensors for Sensitive Detection of the T-2 Toxin

The double‐edged sword of the amoxicillin antibiotic against prostate cancer in nano palladium form and its electrochemical detection of dopamine

The dual therapeutic effect of metformin nuclei‐based drugs modified with one of Tulbaghia violacea extract compounds

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