Study of antibiotic sensitivity pattern of methicillin-resistant Staphylococcus aureus

Abstract

There is a growing concern about the rapid rise in resistance of Staphylococcus aureus to antimicrobial agents. Our objective was to determine the prevalence and pattern of antibiotic sensitivity among Methicillinresistant and Methicillin-sensitive Staphylococcus aureus in Surat, South Gujarat, India. Covering the period of three months from August-2004 to October 2004, we processed the samples of Pus, Urine, Blood, high vaginal swabs, Sputum, throat swabs, drains and ear swabs received from New Civil Hospital, Surat. Total 135 Staphylococci were isolated, out of which, 48 (35.55%) were coagulase positive. These coagulase positive Staphylococci isolates were screened for Methicillin-resistance by a slide latex agglutination kit for the rapid detection of PBP2' (Penicillin binding protein 2a). Sensitivity to amikacin, erythromycin, clindamycin and tetracycline were also carried out following Kirbey Bauer disc diffusion method. Methicillin resistance among the Staphylococcus aureus isolates was 39.5%. Resistance to all antibiotics tested among the Methicillinresistance and Methicillin-sensitive, staphylococci was found to be 26.3% and 6.8% respectively, which is statistically signiÞ cant. Methicillin-resistance is a useful marker in selecting appropriate antimicrobial agents for treatment of infections caused by S. aureus changing pattern of resistance of S. aureus makes its periodic surveillance mandatory.

Prevalence of Multidrug Resistant Staphylococcus aureus and its Antimicrobial Susceptibility Pattern in a Tertiary Care Hospital in Navi Mumbai, India

“…In a study conducted in healthy preschool children in Ujjain, India the Nasal Carriage and Antimicrobial Susceptibility of S. aureus among the 16 MRSA isolates 3 (19%) were MDR which is similar to our result (Ashish Pathak et al, 2010). High percentage (63.6%) of MDRSA has been observed in a study conducted by Rajaduraipandi et al, (2016) Summaiya et al, (2007) found that a high rate of MRSA isolates (26.3%) from the clinical specimens also showed MDRSA. In their study, 6.8% MSSA isolates were resistant to all other antibiotics tested.…”

Study of Community and Hospital Associated Methicillin Resistant Staphylococcus Aureus With Special Reference to Inducible Clindamycin Resistance in a Tertiary Care Hospital

“…[21][22][23] Changing pattern of resistance of S. aureus makes its periodic surveillance mandatory. 24 We observed 34.42 % iMLSB in MRSA, which is correlates with study by P. Sreenivasulu Reddy et al who observed it in 46.2 % iMLSB in MRSA 11 and 15.78 % in CA-MRSA concoredence with Tandra Chadha , but less than Patel M et al reported 33 % CA-MRSA. We recorded 42.85 % iMLSB in HA-MRSA it is less than study of Patel M et al reported 56 %.…”

Antimicrobial Drug Resistance Trends of Bacteremia Isolates in a Rural Hospital in Southern Mozambique

“…28,29 MRSA isolates usually arise from nosocomial infections, and often are associated with high mortality, 30 but community-acquired MRSA has also been reported elsewhere. 18,31 However, the origin of MRSA in our study is not clear because 5 of the 14 children with MRSA were from the demographic surveillance area, and records obtained through the morbidity surveillance system confirm that they had been admitted to the hospital at least once in the preceding four weeks, which suggests that these MRSA may be nosocomial.…”